{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:50:36Z","timestamp":1791640236068,"version":"4.3.4"},"reference-count":51,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Adverse childhood experiences (ACEs) are common and account for more than 25% of psychiatric disorders in youths, but the underlying neurobiological mechanisms associated with risk and resilience among children exposed to ACEs are poorly understood.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To examine associations between ACEs and transdiagnostic psychopathology during the transition to adolescence and to test whether these associations are modified by whole-brain functional connectivity.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study used data from the longitudinal Adolescent Brain Cognitive Development (ABCD) Study\u2019s baseline through 2-year follow-up assessments. A total of 6813 children aged 9 to 11 years at baseline were recruited from 21 US sites between June 1, 2016, and October 31, 2018. Data were analyzed from September 2023 to April 2025.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Lifetime ACEs, assessed from child and parent reports, through 2-year follow-up.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Cumulative number of current DSM-5<\/jats:italic> psychiatric disorders obtained from the computerized self-administered Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5<\/jats:italic> (KSADS-5) through 2-year follow-up and a machine learning\u2013based latent connectome variate (CV) score derived from baseline resting-state functional magnetic resonance imaging data.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 6813 children (mean [SD] age at baseline, 10.0 [0.6] years; 3413 girls [50.1%]) with available baseline neuroimaging, behavioral, and covariate data, the mean (SD) ACE score was 2.3 (1.7) at baseline. ACE scores were significantly associated with the cumulative number of KSADS-5 diagnoses at baseline (\u03b2\u2009=\u20090.11; 95% CI, 0.10-0.12; P<\/jats:italic>\u2009&amp;lt;\u2009.001) and 2-year follow-up (\u03b2\u2009=\u20090.14; 95% CI, 0.12-0.15; P<\/jats:italic>\u2009&amp;lt;\u2009.001). Baseline CV score modified associations between ACEs and psychiatric disorders across the 2 years (\u03b2\u2009=\u2009\u22120.02; 95% CI, \u20130.03 to \u22120.01; t<\/jats:italic>\u2009=\u2009\u22123.34; P<\/jats:italic>\u2009&amp;lt;\u2009.001). Post hoc investigation showed that the modification of the CV score on associations between ACEs and psychopathology was specific to the threat-related ACEs (\u03b2\u2009=\u2009\u22120.04; 95% CI, \u20130.06 to \u22120.02; t<\/jats:italic>\u2009=\u2009\u22123.67; P<\/jats:italic>\u2009&amp;lt;\u2009.001) and was pronounced for girls (\u03b2\u2009=\u2009\u22120.06; 95% CI, \u20130.09 to \u22120.02; t<\/jats:italic>\u2009=\u2009\u22123.33; P<\/jats:italic>\u2009&amp;lt;\u2009.001).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study of children, a whole-brain functional connectivity score derived from neuroimaging data modified the association between ACEs and psychiatric disorders. This modification was particularly seen against threat-related ACEs and was pronounced for female youths. These findings suggest that functional connectivity strength in a broad system relevant to cognitive control may protect preadolescents who have experienced lifetime ACEs\u2014especially girls and those experiencing threat-related ACEs\u2014from developing transdiagnostic psychopathology<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.33136","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T15:30:48Z","timestamp":1758555048000},"page":"e2533136","source":"Crossref","is-referenced-by-count":2,"title":["Modification of Brain Connectome on Association Between Adverse Childhood Experiences and Development of Mental Disorders in Preadolescence"],"prefix":"10.1001","volume":"8","author":[{"given":"Xiang","family":"Xiao","sequence":"first","affiliation":[{"name":"Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland"},{"name":"Department of Psychology, Faculty of Art and Science, 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