{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:46:52Z","timestamp":1792496812168,"version":"4.5.0"},"reference-count":50,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Long COVID presents an unmet therapeutic need.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine the effects of a resistance exercise intervention on exercise capacity, health status, and safety among adults after COVID-19 infection.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n A 2-arm, multicenter, randomized clinical trial including 233 adults with a hospital or community diagnosis of COVID-19 infection in the preceding 12 months was undertaken from June 1, 2021, to April 26, 2024. The intervention group comprised 117 individuals, and the control group comprised 116 individuals. A total of 224 individuals at baseline and 193 individuals at 3 months completed Incremental Shuttle Walk Tests.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n The intervention group received the personalized resistance exercise intervention for 3 months, and the control group received treatment as usual.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was the distance achieved (in meters) in the Incremental Shuttle Walk Test undertaken 3 months after randomization. Secondary outcome measures included health-related quality of life (measured by the European Quality of Life 5-Dimension 5-Level Instrument [EQ-5D-5L]), anxiety and depression (measured by the Patient Health Questionnaire), and grip strength.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 233 adults (median age, 53.6 years [IQR, 43.8-60.8 years]; 146 women [62.7%]; 91 [39.1%] hospitalized with COVID-19 infection) were randomized (117 [50.2%] to the intervention group and 116 [49.8%] to the control group). The median percentage adherence with the exercise intervention was 71.0% (IQR, 47.8%-96.8%), equivalent to performing the exercises 5 days per week. The mean (SD) distance achieved in the Incremental Shuttle Walk Test was 328 (225) m for 224 individuals at baseline and 389 (249) m for 193 individuals at follow-up. The mean (SD) change in Incremental Shuttle Walk Test distance at 3 months compared with baseline was 83 (118) m in the intervention group (n\u2009=\u200994) and 47 (95) m in the control group (n\u2009=\u200998) (adjusted mean difference, 36.5 m [95% CI, 6.6-66.3 m];\n P<\/jats:italic>\n \u2009=\u2009.02). By 3 months, compared with the control group, greater improvements in the intervention group were also observed for the health-related quality of life utility score (EQ-5D-5L) (0.06 [95% CI, 0.01-0.11];\n P<\/jats:italic>\n \u2009=\u2009.02), Patient Health Questionnaire category (0.5 [95% CI, 0.2-0.8];\n P<\/jats:italic>\n \u2009=\u2009.01), and handgrip strength (2.6 kg [95% CI, 0.9-4.2 kg];\n P<\/jats:italic>\n \u2009=\u2009.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this randomized clinical trial, a 3-month program of resistance exercise among adults after COVID-19 infection appeared to improve walking distance, health-related quality of life, anxiety, depression, and grip strength. This pragmatic intervention may be a generalizable therapy for individuals with persisting physical symptoms after COVID-19 infection.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT04900961<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.34304","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:30:17Z","timestamp":1762810217000},"page":"e2534304","source":"Crossref","is-referenced-by-count":8,"title":["Resistance Exercise Therapy After COVID-19 Infection"],"prefix":"10.1001","volume":"8","author":[{"given":"Colin","family":"Berry","sequence":"first","affiliation":[{"name":"British Heart Foundation Glasgow Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom"},{"name":"Department of Cardiology, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde Health Board, Glasgow, 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