{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:43:10Z","timestamp":1785386590749,"version":"3.55.0"},"reference-count":52,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Diabetic retinopathy screening (DRS) rates have historically been low among underserved populations due to barriers in accessing traditional eye care. Although artificial intelligence (AI)\u2013powered DRS provides a potential strategy to improve screening rates, its optimal integration into primary care workflows within federally qualified health centers (FQHCs) requires rigorous evaluation. The clinical workflow of the Diabetic Retinopathy Screening Point-of-Care Artificial Intelligence (DRES-POCAI) trial in FQHCs integrates AI-powered DRS with electronic health records (EHRs) to automate results and prompt referrals, aiming to improve screening rates and facilitate early diagnosis and timely treatment.<\/jats:p><\/jats:sec>Objective<\/jats:title>To increase DRS rates, facilitate early-stage DR detection, improve timely eye specialist follow-up, and assess the effect of DRS on patients\u2019 knowledge, attitudes, self-efficacy, and satisfaction.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>DRES-POCAI is a patient-level, multiclinic, open-label, parallel superiority randomized clinical trial at 2 FQHC sites of San Ysidro Health in San Diego County, California. The study recruitment targets 848 active FQHC patients aged 22 years or older with diabetes, no DRS in the prior 11 months, and scheduled medical visits during the intervention period. Patients with a history of retinopathy or retinal vascular occlusion and other physical or mental conditions are excluded. The study started in June 2024, with recruitment anticipated to conclude in August 2025 and follow-up until February 2026.<\/jats:p><\/jats:sec>Intervention<\/jats:title>The intervention arm receives DRS at their primary care clinic using an AI-powered DRS system, with retinal image analysis to identify more than mild DR and vision-threatening DR. Results are immediately available in the EHRs, and practitioners receive risk-stratified referral recommendations. The usual care arm receives referrals to an FQHC optometrist or external eye care practitioner, with results transmitted to the medical home later.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome is DRS completion status. Secondary outcomes include DR diagnosis stage, specialist referrals, and participants\u2019 DR knowledge, attitudes, and intentions regarding future AI-powered DRS.<\/jats:p><\/jats:sec>Results<\/jats:title>Findings will be disseminated in peer-reviewed publications after data collection and analysis.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>DRES-POCAI will determine the effectiveness of an AI-powered DRS intervention to increase DRS rates in FQHC primary care workflows.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT06721351<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.38114","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:00Z","timestamp":1761058860000},"page":"e2538114","source":"Crossref","is-referenced-by-count":9,"title":["Diabetic Retinopathy Screening Among Federally Qualified Health Center Patients Using Point-of-Care AI"],"prefix":"10.1001","volume":"8","author":[{"given":"Edgar A.","family":"Diaz","sequence":"first","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marva L.","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Gruning","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Stadnick","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla"},{"name":"University of California San Diego Altman Clinical and Translational Research Institute Dissemination and Implementation Science Center, La Jolla"},{"name":"Child and Adolescent Services Research Center, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lugo-Butler","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel N.","family":"Servin","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian I.","family":"Rodr\u00edguez-Rosales","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Geremia","sequence":"additional","affiliation":[{"name":"University of California San Diego Altman Clinical and Translational Research Institute Dissemination and Implementation Science Center, La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaithanya","family":"Ramachandra","sequence":"additional","affiliation":[{"name":"Eyenuk Inc, Woodland Hills, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malavika","family":"Bhaskaranand","sequence":"additional","affiliation":[{"name":"Eyenuk Inc, Woodland Hills, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Howard","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Solis","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Velasquez","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Snook","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Tucker","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima A.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"San Ysidro Health, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"zoi251057r1","doi-asserted-by":"publisher","first-page":"S231","DOI":"10.2337\/dc24-S012","article-title":"12. 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