{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:26:12Z","timestamp":1791095172845,"version":"4.1.0"},"reference-count":47,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Patterns of incidence and factors associated with remission of atopic dermatitis (AD) from birth to adulthood remain understudied.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To examine incidence of AD, its remission probability and trajectories, and early-life factors associated with it in a prospective study from birth to 30 years.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This cohort study used data from the population-based Multicenter Allergy Study (MAS), which recruited full-term newborns from 5 German cities in 1990. Generally healthy newborns were enrolled; the sample was slightly enriched for allergy risk, with more than a third of participants born with 2 parents or siblings with allergies. Until age 30 years, participants were assessed by parental or self-report questionnaires (20 times) and clinical evaluations, including serum samples (9 times).<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Age, sex, age of AD onset, parental allergy status, early-life sensitization against common food and aero-allergens, rhinitis during ages 3 to 5 years, and asthma at age 6 years.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n AD was determined by standardized questionnaire and doctor\u2019s diagnoses. AD remission was defined as being symptom-free for at least 12 months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 1314 recruited participants, 707 (57%) had 1 or 2 allergic parents. Overall, 482 (37%) participated at the 30-year follow-up. The cumulative incidence of AD during the first 5 years was 57% (402 participants) with 1 or 2 allergic parents and 43% (225 participants) with nonallergic parents. The yearly rate of new AD cases declined from age 2 until 13 years and increased slightly thereafter. Among 529 participants with AD onset in the first 5 years of life, 459 (87%) reported no symptoms at age 20 and 30 years. Using data from 658 participants, 4 remission trajectories were identified: early childhood, early school age, substantial adolescence, and partial adulthood remission. Onset within first 2 years of life (adjusted risk ratio [aRR], 1.59; 95%- CI, 1.12-2.26), female sex (aRR, 1.56; 95% CI, 1.23-2.00), early allergic sensitization against at least 1 common aero- or food allergen (aRR, 1.95; 95% CI, 1.25-3.05), asthma at age 6 years (aRR, 2.22; 95% CI, 1.70-2.89), and allergic rhinitis at ages 3 to 5 years (aRR, 1.54; 95% CI, 1.21-1.95) were associated with the persistent phenotype.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of children with allergic diseases, AD before school age was generally associated with a favorable long-term prognosis. However, remission was less likely in female participants, those with onset before age 2 years, those with specific serum antibodies to common allergens before school age, or those with allergic comorbidity, highlighting the need for increased clinical attention and further investigation into underlying mechanisms.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.44324","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:00:28Z","timestamp":1765209628000},"page":"e2544324","source":"Crossref","is-referenced-by-count":3,"title":["Incidence and Remission of Atopic Dermatitis in a German Birth Cohort"],"prefix":"10.1001","volume":"8","author":[{"given":"Chu-Wei","family":"Hung","sequence":"first","affiliation":[{"name":"Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Berlin, 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