{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:33:34Z","timestamp":1790721214068,"version":"4.1.0"},"reference-count":10,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi250204-4\"><jats:title>Importance<\/jats:title><jats:p>Pancreas cancer is the seventh leading cause of cancer death and colorectal cancer is the second leading cause of cancer death worldwide, with increasing incidence for both, particularly in younger age cohorts.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250204-5\"><jats:title>Objective<\/jats:title><jats:p>To report updated incidence trends for pancreas and colorectal adenocarcinomas in the US, with the specific intent of examining the annual percentage changes (APCs) in younger age groups.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250204-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This retrospective cohort study used data from the Surveillance, Epidemiology, and End Results database to examine incidence trends from 2000 to 2021. Individuals with pancreatic and colorectal adenocarcinoma were included. Data through 2021 were released on April 17, 2024. Data analysis occurred from December 4, 2024, to February 1, 2025.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250204-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Yearly incidence rates were obtained for pancreatic and colorectal adenocarcinoma. Temporal trends of pancreas adenocarcinoma incidence rates by covariates were measured by APC and 95% CIs.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250204-8\"><jats:title>Results<\/jats:title><jats:p>From 2000 to 2021, 275\u202f273 cases of pancreas adenocarcinoma were identified (142\u202f633 male patients [51.8%]; 239\u202f840 patients [87.1%] aged \u226555 years). The APC for pancreatic adenocarcinoma was 4.35 (95% CI, 2.03 to 6.73) in the group aged 15 to 34 years, which was statistically significantly higher than the APCs of 1.74 (95% CI, 1.59 to 1.89) (<jats:italic>P<\/jats:italic>\u2009=\u2009.007) for the group aged 55 years and older and 1.54 (95% CI, 1.18 to 1.90) (<jats:italic>P<\/jats:italic>\u2009=\u2009.004) for the group aged 35 to 54 years. A total of 1\u202f215\u202f200 cases of colorectal cancer were identified (641\u202f776 male patients [52.8%]; 976\u202f716 patients [80.4%] aged \u226555 years). The APC for colorectal adenocarcinoma was \u22123.31 (95% CI, \u22123.54 to \u22123.08) for the group aged 55 years and older, which was statistically significantly lower than the APCs of 1.75 (95% CI, 1.08 to 2.42) (<jats:italic>P<\/jats:italic>\u2009=\u2009.001) for the group aged 15 to 34 years and 0.78 (95% CI, 0.51 to 1.06) (<jats:italic>P<\/jats:italic>\u2009=\u2009.002) for the group aged 35 to 54 years.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250204-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The findings of this cohort study suggest that the incidence of pancreatic adenocarcinoma has increased among all age groups, whereas that of colorectal adenocarcinoma has increased among younger age groups. Clinicians should be aware of this trend when evaluating younger patients with relevant symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.4682","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T15:00:39Z","timestamp":1744642839000},"page":"e254682","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of Pancreas and Colorectal Adenocarcinoma in the US"],"prefix":"10.1001","volume":"8","author":[{"given":"Arvind","family":"Bussetty","sequence":"first","affiliation":[{"name":"Department of Medicine, Rutgers University School of Medicine, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros C.","family":"Benias","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey"},{"name":"RWJBarnabas Health System, Robert Wood Johnson University Hospital, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey"},{"name":"RWJBarnabas Health System, Robert Wood Johnson University Hospital, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Stewart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind J.","family":"Trindade","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey"},{"name":"RWJBarnabas Health System, Robert Wood Johnson University Hospital, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"issue":"4","key":"zoi250204r1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s10620-024-08292-1","article-title":"Epidemiology and socioeconomic impact of pancreatic cancer: an analysis of the Global Burden of Disease Study 1990-2019.","volume":"69","author":"Ramai","year":"2024","journal-title":"Dig Dis Sci"},{"issue":"20","key":"zoi250204r2","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1001\/jama.2021.18859","article-title":"Incidence of pancreatic cancer by age and sex in the US, 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