{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:18:12Z","timestamp":1792815492948,"version":"4.5.0"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Congenital cytomegalovirus (cCMV) is the most common nongenetic cause of sensorineural hearing loss in children and a cause of long-term neurological disabilities. In the absence of universal screening, cCMV disease in many newborns will go undiagnosed and untreated.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine the feasibility, screen-positive rate, and parental acceptance of newborn screening for cCMV using dried blood spot (DBS) specimens.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n In this population-based diagnostic study, newborns whose DBS specimens were submitted to the New York State Newborn Screening Program from October 2, 2023, through September 30, 2024, for routine screening were also screened for CMV. Parents were given the option to opt out of receiving CMV results. Infectious disease specialists at designated medical centers performed follow-up of referred newborns. Of the 208\u202f322 newborns whose specimens were submitted, 245 (0.1%) were opted out of the CMV screen by their parents; 22 families did so after CMV results were released.<\/jats:p>\n <\/jats:sec>\n \n Exposure<\/jats:title>\n DBS screening of newborns.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n CMV was detected in DBS specimens from newborns using a quantitative polymerase chain reaction analysis. Appropriate follow-up and treatment were provided to referred newborns.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 208\u202f099 newborns (48.6% female and 51.0% male; mean [SD] age at specimen collection, 3.5 [12.3] days [median, 1.0 days]) whose CMV results were reported, 529 had positive CMV screen results (0.3%). Following referral and initial diagnostic evaluation, 276 of the 529 newborns (52.2%) were diagnosed with cCMV (overall rate of 0.1%). Among the 276 newborns with cCMV, 68 (24.6%) had symptomatic cCMV disease, 197 (71.4%) had asymptomatic infection, and 11 (4.0%) had isolated sensorineural hearing loss. Additionally, 131 of the 529 referred newborns (24.8%) had likely acquired CMV postnatally, 17 (3.2%) had false-positive screen results, 43 (8.1%) had unknown CMV classification, and 62 (11.7%) were lost to follow-up or their parents declined follow-up. Of the 68 newborns with symptomatic cCMV disease, 48 (70.6%) were treated with antiviral medication.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this diagnostic study, early identification of cCMV allowed newborns to be evaluated, which provided an opportunity for improved outcomes. Although the intent of the screening was to detect cCMV, a sizeable minority of cases identified had postnatally acquired CMV infections. Further studies that incorporate long-term data are needed to better understand the impact of cCMV identification among newborns with asymptomatic infection.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.54518","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:30:27Z","timestamp":1769704227000},"page":"e2554518","source":"Crossref","is-referenced-by-count":10,"title":["Universal Newborn Screening for Congenital Cytomegalovirus Using Dried Blood Spot Specimens"],"prefix":"10.1001","volume":"9","author":[{"given":"Norma P.","family":"Tavakoli","sequence":"first","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"},{"name":"Department of Biomedical Sciences, State University of New York, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Sack","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Handel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Giacinto","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Pearce","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeyinwa","family":"Ojukwu","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charity","family":"McManaman","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"St-Pierre","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"DiAntonio","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Saavedra-Matiz","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Brandon","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lequela","family":"Steen","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Weill Cornell Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Sood","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cohen Children\u2019s Medical Center, Northwell, New Hyde Park, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Piwoz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Albert Einstein College of Medicine, Children\u2019s Hospital at Montefiore, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnie","family":"John","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, New York Presbyterian Hospital, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"DeLaMora","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, New York Medical College, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, New York Medical College, Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie P.","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NYU (New York University) Grossman School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, SUNY (State University of New York) Upstate Medical University, Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, SUNY (State University of New York) Upstate Medical University, Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, UR-Medicine Golisano Children\u2019s Hospital, Rochester, New 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Millie Duker Children\u2019s Hospital, Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Nachman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bradley","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Kay","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Caggana","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, 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