{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:53:33Z","timestamp":1781862813542,"version":"3.54.5"},"reference-count":67,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi251481-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Geriatric syndromes are common in hospitalized older adults and complicate acute care; however, their overall prevalence and cumulative burden remain poorly understood, especially in resource-limited settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi251481-5\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To measure the prevalence of geriatric syndromes upon hospital admission and examine the independent association between the number of geriatric syndromes and 90-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi251481-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This cohort study used data from the Creating a Hospital Assessment Network in Geriatrics (CHANGE) study, a multicenter, prospective cohort of 43 hospitals, including 38 in Brazil, 1 in Angola, 1 in Chile, 2 in Colombia, and 1 in Portugal. Consecutive patients aged 65 years or older admitted under geriatric teams between June 1, 2022, and December 31, 2023, were enrolled within 48 hours; patients with terminally illness were excluded. Data were analyzed from February 1 to November 23, 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi251481-7\">\n                    <jats:title>Exposure<\/jats:title>\n                    <jats:p>A standardized comprehensive geriatric assessment captured 14 geriatric syndromes: loneliness, dementia, depressive symptoms, sensory impairment, disability, immobility, incontinence, falls, frailty, malnutrition, pressure ulcers, polypharmacy, potentially inappropriate medications, and delirium. The exposure of interest was the within-patient count of syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi251481-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>The primary outcome was 90-day all-cause mortality, ascertained by masked telephone follow-up with verification in medical records or public registries. Prespecified mixed-effects Cox proportional hazards regression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi251481-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 2556 participants (mean [SD] age, 79 [9] years, 1437 female [56.2%]). The median number of geriatric syndromes was 5 (IQR, 3-8). The highest prevalence rates for syndromes were 70.8% (95% CI, 69.1%-72.6%) for disability, 61.7% (95% CI, 59.8%-63.6%) for polypharmacy, 58.2% (95% CI, 56.3%-60.1%) for frailty, and 54.7% (95% CI, 52.8%-56.7%) for sensory impairment. Across categories, the mortality rate rose from 8.4% (95% CI, 6.2%-11.4%) for 0 to 2 syndromes to 12.7% (95% CI, 10.1%-15.7%) for 3 to 4 syndromes, 25.4% (95% CI, 22.2%-29.1%) for 5 to 6 syndromes, 30.4% (95% CI, 26.7%-34.5%) for 7 to 8 syndromes, 39.5% (95% CI, 34.4%-44.8%) for 9 to 10 syndromes, and 47.0% (95% CI, 36.4%-57.9%) for 11 or more syndromes. After adjusting for confounders, each additional geriatric syndrome was associated with an increased risk of mortality (hazard ratio,\u20091.22 [95% CI,\u20091.15-1.30), which became increasingly pronounced in older age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi251481-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>This cohort study found that hospitalized older adults had a median of 5 geriatric syndromes, which were independently and incrementally associated with 90-day mortality. Multidomain assessments should be integrated into standard hospital care to identify and address vulnerabilities that commonly affect older adults with acute illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.55740","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:00:31Z","timestamp":1769529631000},"page":"e2555740","source":"Crossref","is-referenced-by-count":7,"title":["Geriatric Syndromes and Mortality Among Hospitalized Older Adults"],"prefix":"10.1001","volume":"9","author":[{"given":"Thiago J.","family":"Avelino-Silva","sequence":"first","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servi\u00e7o de Geriatria, Hospital das Cl\u00ednicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Division of Geriatrics, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda B.","family":"Roma","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servi\u00e7o de Geriatria, Hospital das Cl\u00ednicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Hospital das Cl\u00ednicas da Unicamp, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana F.","family":"Dutra","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Hospital Lus\u00edadas Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina C.","family":"Speranza","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Pedro Ernesto, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlety M. C.","family":"Casale","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio da Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz N. 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