{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:25:16Z","timestamp":1791699916387,"version":"4.3.4"},"reference-count":56,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi250271-4\"><jats:title>Importance<\/jats:title><jats:p>At birth, neonates with congenital heart disease (CHD) have smaller placentas, lower birth weight, and smaller head circumferences compared with healthy neonates. The onset of feto-placental growth disturbances, however, is not well known.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250271-5\"><jats:title>Objective<\/jats:title><jats:p>To compare fetal body volumes, assess differences in the fetal to placental volume ratios (placental growth relative to the fetus), and investigate the association between in utero fetal body and total brain volume in fetuses with and without CHD.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250271-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This case-control study enrolled pregnant women with a fetal diagnosis of CHD and those with healthy pregnancies at Children\u2019s National Hospital in Washington, DC, from April 2018 to July 2023. Fetal magnetic resonance imaging was obtained up to 2 time points during pregnancy. The fetal to placental ratio was calculated using 3-dimensional magnetic resonance image fetal body volumes and placental volumes.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250271-7\"><jats:title>Exposure<\/jats:title><jats:p>In utero environment CHD.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250271-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The main outcomes were the trajectories of body, brain, and placental volumetric growth in fetuses with CHD and in control fetuses. Generalized linear regression and mixed-effects models were applied to identify associations for fetal body volume and fetal to placental volume ratios between CHD and control groups adjusting for fetal sex and gestational age at the time of the magnetic resonance imaging scan.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250271-9\"><jats:title>Results<\/jats:title><jats:p>The study included 108 fetuses (59 male [54.6%]), of which 55 were in the healthy control group (with 55 scans), and 53 had CHD (with 77 scans). Fetal body volumes in fetuses with CHD were smaller compared with control fetuses (\u03b2 = \u2212193.60 [SE,\u200944.42]; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) with larger fetal to placental volume ratios (\u03b2\u2009=\u20090.23 [SE,\u20090.10]; <jats:italic>P<\/jats:italic>\u2009=\u2009.02). The total brain volume was smaller in fetuses with CHD compared with control fetuses (\u03b2\u2009=\u2009\u221210.87 [SE, 5.09]; <jats:italic>P<\/jats:italic> = .04).<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250271-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this case-control study of fetuses with and without CHD, those with CHD demonstrated impaired fetal body growth with higher fetal to placental volume ratios and smaller total brain volume, suggesting that placental failure was associated with growth disturbances in CHD, as demonstrated by the large fetal to placental volume ratios. Additional studies should assess the onset and progression of placental dysfunction and how the timing of placental failure may contribute to neurodevelopmental disability in survivors of CHD.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.7217","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T15:31:08Z","timestamp":1745508668000},"page":"e257217","source":"Crossref","is-referenced-by-count":13,"title":["Placental and Fetal In Utero Growth Among Fetuses With Congenital Heart Disease"],"prefix":"10.1001","volume":"8","author":[{"given":"Marin","family":"Jacobwitz","sequence":"first","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal","family":"Kapse","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Ngwa","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josepheen","family":"De Asis-Cruz","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wu","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Donofrio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"McDermott","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adre","family":"du Plessis","sequence":"additional","affiliation":[{"name":"Prenatal Pediatrics Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Limperopoulos","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"},{"name":"Prenatal Pediatrics Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickie","family":"Andescavage","sequence":"additional","affiliation":[{"name":"Developing Brain Institute, Children\u2019s National Hospital, Washington, DC"},{"name":"Prenatal Pediatrics Institute, Children\u2019s National Hospital, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"issue":"4","key":"zoi250271r1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome.","volume":"594","author":"Miller","year":"2016","journal-title":"J Physiol"},{"key":"zoi250271r4","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1016\/S0301-2115(03)00179-9","article-title":"Placental insufficiency and its consequences.","volume":"110","author":"Gagnon","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"zoi250271r5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.siny.2004.03.005","article-title":"Paediatric consequences of fetal growth restriction.","volume":"9","author":"Yanney","year":"2004","journal-title":"Semin Fetal Neonatal Med"},{"issue":"3","key":"zoi250271r6","first-page":"372","article-title":"Neurodevelopmental consequences of being born SGA.","volume":"2","author":"van Wassenaer","year":"2005","journal-title":"Pediatr Endocrinol Rev"},{"issue":"4","key":"zoi250271r7","doi-asserted-by":"publisher","first-page":"e883","DOI":"10.1542\/peds.2010-2442","article-title":"Neurologic outcomes at school age in very preterm infants born with severe or mild growth restriction.","volume":"127","author":"Guellec","year":"2011","journal-title":"Pediatrics"},{"issue":"2","key":"zoi250271r8","doi-asserted-by":"publisher","first-page":"130.e1","DOI":"10.1016\/j.ajog.2012.11.014","article-title":"Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction.","volume":"208","author":"von Beckerath","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"zoi250271r9","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1016\/j.placenta.2008.12.006","article-title":"Intrauterine growth restriction: implications for placental metabolism and transport: a review.","volume":"30","author":"Cetin","year":"2009","journal-title":"Placenta"},{"issue":"4","key":"zoi250271r10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ajog.2010.08.055","article-title":"Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management.","volume":"204","author":"Figueras","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"zoi250271r11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ejogrb.2013.05.006","article-title":"Myo-inositol metabolism in appropriately grown and growth-restricted fetuses: a proton magnetic resonance spectroscopy study.","volume":"170","author":"Story","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"zoi250271r12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00003081-199203000-00015","article-title":"Intrauterine growth retardation: definition, classification, and etiology.","volume":"35","author":"Pollack","year":"1992","journal-title":"Clin Obstet Gynecol"},{"issue":"3","key":"zoi250271r13","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/0002-9378(93)90646-Z","article-title":"Effects of long-term, high-altitude hypoxemia on ovine fetal cardiac output and blood flow distribution.","volume":"169","author":"Kamitomo","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"zoi250271r14","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1016\/j.earlhumdev.2011.12.026","article-title":"Foetal volumetry using magnetic resonance imaging in intrauterine growth restriction.","volume":"88","author":"Damodaram","year":"2012","journal-title":"Early Hum Dev"},{"issue":"3","key":"zoi250271r15","doi-asserted-by":"publisher","first-page":"R151","DOI":"10.1152\/ajpregu.00036.2014","article-title":"Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus.","volume":"308","author":"Poudel","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"zoi250271r16","doi-asserted-by":"publisher","first-page":"613.e1","DOI":"10.1016\/j.ajog.2009.07.028","article-title":"Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus.","volume":"201","author":"Miller","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"zoi250271r17","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s00246-002-0404-0","article-title":"Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect.","volume":"24","author":"Donofrio","year":"2003","journal-title":"Pediatr Cardiol"},{"issue":"3","key":"zoi250271r18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1113\/EP090442","article-title":"Placental adaptations supporting fetal growth during normal and adverse gestational environments.","volume":"108","author":"Sferruzzi-Perri","year":"2023","journal-title":"Exp Physiol"},{"issue":"6","key":"zoi250271r19","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00246-018-1876-x","article-title":"Characterization of the placenta in the newborn with congenital heart disease: distinctions based on type of cardiac malformation.","volume":"39","author":"Rychik","year":"2018","journal-title":"Pediatr Cardiol"},{"issue":"2","key":"zoi250271r20","doi-asserted-by":"publisher","first-page":"231.e1","DOI":"10.1016\/j.ajog.2022.08.013","article-title":"Placental delayed villous maturation is associated with fetal congenital heart disease.","volume":"228","author":"O\u2019Hare","year":"2023","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"zoi250271r21","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/pd.5515","article-title":"The association between severe fetal congenital heart defects and placental vascular malperfusion lesions.","volume":"39","author":"Miremberg","year":"2019","journal-title":"Prenat Diagn"},{"issue":"4","key":"zoi250271r22","doi-asserted-by":"publisher","first-page":"620.e1","DOI":"10.1016\/j.ajog.2022.05.038","article-title":"Placental vascular malperfusion lesions in fetal congenital heart disease.","volume":"227","author":"Leon","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"zoi250271r23","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/s41390-021-01521-7","article-title":"Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.","volume":"91","author":"Leon","year":"2022","journal-title":"Pediatr Res"},{"issue":"1","key":"zoi250271r24","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.1038\/s41598-019-40894-y","article-title":"Placental pathology and neuroimaging correlates in neonates with congenital heart disease.","volume":"9","author":"Schlatterer","year":"2019","journal-title":"Sci Rep"},{"issue":"5","key":"zoi250271r25","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00246-022-03018-4","article-title":"The relationship between placental pathology and neurodevelopmental outcomes in complex congenital heart disease.","volume":"44","author":"Segar","year":"2023","journal-title":"Pediatr Cardiol"},{"issue":"12","key":"zoi250271r26","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1093\/oxfordjournals.aje.a115839","article-title":"Birth weight and cardiovascular malformations: a population-based study: the Baltimore-Washington Infant Study.","volume":"133","author":"Rosenthal","year":"1991","journal-title":"Am J Epidemiol"},{"issue":"3","key":"zoi250271r27","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jtcvs.2008.10.025","article-title":"Brain maturation is delayed in infants with complex congenital heart defects.","volume":"137","author":"Licht","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"zoi250271r28","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/oxfordjournals.aje.a008771","article-title":"Patterns of prenatal growth among infants with cardiovascular malformations: possible fetal hemodynamic effects.","volume":"143","author":"Rosenthal","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"8","key":"zoi250271r29","doi-asserted-by":"publisher","first-page":"S232","DOI":"10.1097\/PCC.0000000000000800","article-title":"Neurodevelopmental outcomes in children with congenital heart disease\u2014what can we impact?","volume":"17","author":"Wernovsky","year":"2016","journal-title":"Pediatr Crit Care Med"},{"issue":"9","key":"zoi250271r30","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1161\/CIR.0b013e318265ee8a","article-title":"Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association.","volume":"126","author":"Marino","year":"2012","journal-title":"Circulation"},{"issue":"5","key":"zoi250271r31","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033189","article-title":"Placental pathology contributes to impaired volumetric brain development in neonates with congenital heart disease.","volume":"13","author":"Nijman","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"20","key":"zoi250271r32","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1161\/CIRCULATIONAHA.116.021793","article-title":"Congenital heart defects and indices of placental and fetal growth in a nationwide study of 924?422 liveborn infants.","volume":"134","author":"Matthiesen","year":"2016","journal-title":"Circulation"},{"key":"zoi250271r33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ijdevneu.2019.01.003","article-title":"The placenta as a window to the brain: a review on the role of placental markers in prenatal programming of neurodevelopment.","volume":"73","author":"Shallie","year":"2019","journal-title":"Int J Dev Neurosci"},{"issue":"2","key":"zoi250271r34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.cjca.2022.09.020","article-title":"Fetal brain development in congenital heart disease.","volume":"39","author":"Peyvandi","year":"2023","journal-title":"Can J Cardiol"},{"issue":"7","key":"zoi250271r35","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025516","article-title":"Impaired maternal-fetal environment and risk for preoperative focal white matter injury in neonates with complex congenital heart disease.","volume":"12","author":"Licht","year":"2023","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"zoi250271r36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/CIRCULATIONAHA.109.865568","article-title":"Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy.","volume":"121","author":"Limperopoulos","year":"2010","journal-title":"Circulation"},{"issue":"15","key":"zoi250271r37","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1161\/CIRCULATIONAHA.114.013051","article-title":"Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease.","volume":"131","author":"Sun","year":"2015","journal-title":"Circulation"},{"issue":"19","key":"zoi250271r38","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1056\/NEJMoa067393","article-title":"Abnormal brain development in newborns with congenital heart disease.","volume":"357","author":"Miller","year":"2007","journal-title":"N Engl J Med"},{"issue":"9","key":"zoi250271r39","doi-asserted-by":"publisher","first-page":"e569","DOI":"10.1542\/neo.24-9-e569","article-title":"The placenta in congenital heart disease: form, function and outcomes.","volume":"24","author":"Josowitz","year":"2023","journal-title":"Neoreviews"},{"issue":"1","key":"zoi250271r40","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/HCO.0000000000000816","article-title":"The placenta as the window to congenital heart disease.","volume":"36","author":"Cohen","year":"2021","journal-title":"Curr Opin Cardiol"},{"issue":"2","key":"zoi250271r41","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0022-5223(00)70191-7","article-title":"Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate.","volume":"119","author":"Clancy","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"9","key":"zoi250271r42","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1109\/TMI.2015.2415453","article-title":"Fast volume Reconstruction from motion corrupted stacks of 2D slices.","volume":"34","author":"Kainz","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"issue":"9","key":"zoi250271r43","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.placenta.2015.06.013","article-title":"3-D volumetric MRI evaluation of the placenta in fetuses with complex congenital heart disease.","volume":"36","author":"Andescavage","year":"2015","journal-title":"Placenta"},{"issue":"7","key":"zoi250271r44","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/s41372-022-01340-6","article-title":"Measuring intrauterine growth in healthy pregnancies using quantitative magnetic resonance imaging.","volume":"42","author":"Amgalan","year":"2022","journal-title":"J Perinatol"},{"issue":"2","key":"zoi250271r45","doi-asserted-by":"publisher","first-page":"173.e1","DOI":"10.1016\/j.ajog.2011.10.002","article-title":"Normative fetal brain growth by quantitative in vivo magnetic resonance imaging.","volume":"206","author":"Clouchoux","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"zoi250271r46","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability.","volume":"31","author":"Yushkevich","year":"2006","journal-title":"Neuroimage"},{"issue":"13","key":"zoi250271r47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2431-3-13","article-title":"A new growth chart for preterm babies: Babson and Benda\u2019s chart updated with recent data and a new format.","volume":"3","author":"Fenton","year":"2003","journal-title":"BMC Pediatr"},{"issue":"17","key":"zoi250271r48","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010262","article-title":"Growth in congenital heart disease: outcome or predictor?","volume":"7","author":"Miller","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"zoi250271r49","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3109\/14767058.2011.597900","article-title":"Fetal congenital heart disease and intrauterine growth restriction: a retrospective cohort study.","volume":"25","author":"Wallenstein","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"FEB","key":"zoi250271r50","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental adaptation: what can we learn from birthweight:placental weight ratio?","volume":"7","author":"Hayward","year":"2016","journal-title":"Front Physiol"},{"issue":"5","key":"zoi250271r51","doi-asserted-by":"publisher","first-page":"484","DOI":"10.7150\/ijms.23107","article-title":"Impact of placental weight and fetal\/placental weight ratio Z score on fetal growth and the perinatal outcome.","volume":"15","author":"Matsuda","year":"2018","journal-title":"Int J Med Sci"},{"issue":"5","key":"zoi250271r52","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/aogs.12105","article-title":"Fetal death and placental weight\/birthweight ratio: a population study.","volume":"92","author":"Haavaldsen","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"5","key":"zoi250271r53","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jpeds.2014.01.002","article-title":"Encephalopathy of congenital heart disease- destructive and developmental effects intertwined.","volume":"164","author":"Volpe","year":"2014","journal-title":"J Pediatr"},{"issue":"1","key":"zoi250271r54","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol"},{"issue":"2","key":"zoi250271r55","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10456-005-9007-8","article-title":"Vascular biology in implantation and placentation.","volume":"8","author":"Huppertz","year":"2005","journal-title":"Angiogenesis"},{"issue":"1","key":"zoi250271r56","doi-asserted-by":"publisher","first-page":"10756","DOI":"10.1038\/s41598-022-14955-8","article-title":"Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease.","volume":"12","author":"Wilson","year":"2022","journal-title":"Sci Rep"},{"key":"zoi250271r2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/978-1-4471-0735-4_19","volume-title":"Intrauterine Growth Restriction: Aetiology and Management","author":"Blair","year":"2000"},{"key":"zoi250271r3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-1-4471-0735-4_18","volume-title":"Intrauterine Growth Restriction: Aetiology and Management","author":"Marlow","year":"2000"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2833187\/jacobwitz_2025_oi_250271_1744833340.43732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T15:31:09Z","timestamp":1745508669000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2833187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2025.7217","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]}}}