{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:51:01Z","timestamp":1782143461840,"version":"3.54.5"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi260543-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi260543-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether participation in 1 season of youth soccer is associated with changes in cognition, behavior, balance, brain structure or function, or blood biomarkers compared with noncontact sports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi260543-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>Prospective longitudinal cohort study at European centers (Munich, Germany; Leuven, Belgium; and Oslo, Norway). Male adolescent soccer players and noncontact athletes were each studied across a single competitive season with assessments at preseason, postseason, and 2 months later. Data were analyzed from January 2023 to March 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi260543-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Soccer players were compared with noncontact athletes. In addition, self-reported heading of a soccer ball was assessed among soccer players as a measure of RHI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi260543-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Cognition, behavior, balance, magnetic resonance imaging (brain structure, function, and biochemistry), and plasma biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi260543-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Male adolescent soccer players (n\u2009=\u200982; mean [SD] age, 14.8 [0.6] years) did not differ from noncontact sport athletes (n\u2009=\u200947; mean [SD] age, 14.7 [0.7] years) in cognition, behavior, balance, cortical thickness, brain volumes, white-matter microstructure, or functional connectivity. At preseason, soccer players had higher total N-acetylaspartate (tNAA; \u03b2, \u22120.379 [95% CI, \u22120.627 to \u22120.131];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003), glial fibrillary acidic protein (GFAP; \u03b2, \u22120.055 [95% CI, \u22120.103 to \u22120.006];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.03), and neurofilament light chain (NfL; \u03b2, \u22120.071 [95% CI, \u22120.122 to \u22120.020];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01) than noncontact sport controls. Across the season, tNAA (\u03b2, 0.047 [95% CI, 0.020-0.074];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001) declined in soccer players and increased in controls, converging by postseason. Group trajectories of GFAP and NfL did not differ between groups. Within soccer players, heading exposure was not significantly associated with changes in any outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi260543-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this cohort study of adolescent males, no statistically significant differences were detected over 1 season between soccer players and noncontact sport athletes in cognition, behavior, or brain structure and function. Group differences in GFAP and NfL may represent early signs of exposure, but lack of association with heading exposure warrants further investigation. These results highlight the need for large, multiyear studies to inform health policy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.19569","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:30:28Z","timestamp":1782142228000},"page":"e2619569","source":"Crossref","is-referenced-by-count":0,"title":["Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes"],"prefix":"10.1001","volume":"9","author":[{"given":"Inga K.","family":"Koerte","sequence":"first","affiliation":[{"name":"cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany"},{"name":"Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Mass General Brigham, Harvard Medical School, Boston, Massachusetts"},{"name":"German Center for Child and Adolescent Health (DZKJ), partner site Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim L. 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