{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:10:10Z","timestamp":1782857410653,"version":"3.54.5"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Congenital diaphragmatic hernia (CDH) is a rare malformation with high neonatal mortality. Although advances in management have improved survival rates, long-term morbidity remains substantial, and its impact on the health care system, particularly hospital readmissions, remains poorly described.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To describe the incidence, causes, and factors associated with hospital readmission and late mortality after discharge from the primary stay.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This nationwide retrospective cohort study was conducted from 2012 to 2024 and used data from the French National Health Data System, capturing nationwide health insurance claims and hospital discharge records in France. Participants were children with CDH who underwent surgical repair within the first 6 months of life, and were discharged alive from the primary stay. Data were analyzed from January to October 2025.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcomes were readmission to an acute care facility within 3 years after discharge and death during follow-up. Factors associated with readmission were identified using multivariable analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 1028 included infants (median [IQR] birth weight, 3050 [2720-3410] g; 849 [82.6%] with full-term birth; 630 [61.3%] male infants), 753 had at least 3 years of follow-up (median [IQR] time of follow-up, 6.2 [2.6-9.1] years), constituting the overall sample size for the primary analysis. Of them, 546 children (72.5%) were readmitted at least once, and 182 (24.2%) required intensive care. At 3 years, 208 (38.0%), 112 (20.5%), and 127 (23.3%) children had experienced at least 1 readmission for respiratory causes, gastrointestinal and\/or nutritional issues, and CDH-related surgical complications, respectively. Preterm birth (incidence rate ratio [IRR], 1.32; 95% CI, 1.10-1.60), associated congenital anomalies (IRR, 1.31; 95% CI, 1.13-1.53), a primary stay longer than 1 month (IRR, 1.50; 95% CI, 1.27-1.76), oxygen therapy at discharge (IRR, 2.14; 95% CI, 1.55-2.99), and enteral feeding at discharge (IRR, 2.21; 95% CI, 1.83-2.68) were independently associated with readmission. Fourteen late deaths (14 of 1028 infants [1.4%]) were recorded, attributable to CDH-related complications or associated comorbidities in half of cases. Enteral feeding at discharge was also independently associated with late mortality (hazard ratio, 5.09; 95% CI, 1.33-19.48).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of 1028 children with CDH, nearly three-quarters were readmitted within 3 years, but late mortality was low. Although enteral feeding at discharge likely reflected CDH severity, it may also represent a potentially modifiable target that warrants further investigation to improve outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.20290","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:34:49Z","timestamp":1782747289000},"page":"e2620290","source":"Crossref","is-referenced-by-count":0,"title":["Readmission and Late Mortality Among Children With Congenital Diaphragmatic Hernia"],"prefix":"10.1001","volume":"9","author":[{"given":"Marine","family":"Jouannin","sequence":"first","affiliation":[{"name":"Assistance Publique-Hopitaux de Paris, H\u00f4pital Necker-Enfants malades, Neonatal Intensive Care Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Pinson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Assistance Publique-Hopitaux de Paris, H\u00f4pital Necker-Enfants malades, Clinical Research Unit and UMRS 1343 INSERM, Perinatal and Pediatric Pharmacology and Therapeutic Assessment, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathis","family":"Collier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Assistance Publique-Hopitaux de Paris, H\u00f4pital Necker-Enfants malades, Clinical Research Unit and UMRS 1343 INSERM, Perinatal and Pediatric Pharmacology and Therapeutic Assessment, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Assistance Publique-Hopitaux de Paris, H\u00f4pital Necker-Enfants malades, Neonatal Intensive Care Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Tr\u00e9luyer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Assistance Publique-Hopitaux de Paris, H\u00f4pital Necker-Enfants malades, Clinical Research Unit and UMRS 1343 INSERM, Perinatal and Pediatric Pharmacology and Therapeutic Assessment, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Kermorvant-Duchemin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Assistance Publique-Hopitaux de Paris, H\u00f4pital Necker-Enfants malades, Neonatal Intensive Care Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"issue":"1","key":"zoi260568r1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41572-022-00362-w","article-title":"Congenital diaphragmatic hernia.","volume":"8","author":"Zani","year":"2022","journal-title":"Nat Rev Dis 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Protocole national de diagnostic et de soins\u2014hernie de coupole diaphragmatique cong\u00e9nitale. September 2020. Accessed May 20, 2026. https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2020-10\/pnds_hdc_septembre_2020.pdf"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2850949\/jouannin_2026_oi_260568_1782852611.64606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:29:51Z","timestamp":1782854991000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2850949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2026.20290","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}