{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:00:48Z","timestamp":1785168048118,"version":"3.55.0"},"reference-count":15,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n The decision to transfuse a patient with myocardial infarction (MI) and anemia at a higher vs lower hemoglobin threshold must consider the potential benefit of reduced risk of 30-day death or MI and the potential risk of heart failure.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To estimate bayesian posterior risk differences and posterior probabilities that a liberal vs restrictive transfusion strategy is associated with reduced risk of 30-day death or MI and whether the probabilities exceed predefined thresholds.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n The Myocardial Ischemia and Transfusion (MINT) trial recruited adults from April 26, 2017, to April 14, 2023, who were hospitalized with MI and anemia at 144 sites in 6 countries. Statistical analysis was performed from July 31, 2024, to February 18, 2026.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n The MINT trial randomized participants to a restrictive (transfuse if hemoglobin is &amp;lt;7 to 8 g\/dL) or liberal (maintain hemoglobin at &amp;gt;10 g\/dL) transfusion strategy.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Bayesian posterior risk differences were estimated for 30-day death or MI and for heart failure using 3 prior beliefs regarding the treatment strategies: noninformative, liberal strategy superiority, or restrictive strategy superiority.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The mean (SD) age of the 3504 participants was 72.1 (11.6) years and 1911 (54.5%) were men. Compared with the restrictive strategy, the risk of 30-day death or MI with the liberal strategy was 1.4% (95% credible interval, \u22120.8% to 3.5%) to 2.4% (95% credible interval, 0.3%-4.6%) lower, depending on prior beliefs. The probability that the liberal strategy was associated with a lower risk of 30-day death or MI ranged from 89.1% to 98.8%, and the probability that a liberal strategy was associated with at least 1 less death or MI per 100 treated was between 62.7% and 90.4%. Conversely, the risk of heart failure with the liberal strategy was 0.2% (95% credible interval, \u22121.6% to 1.2%) to 0.6% (95% credible interval, \u22122.0% to 0.8%) higher compared with the restrictive strategy, depending on prior beliefs. The probability that the liberal strategy was associated with a higher risk of heart failure ranged from 60.6% to 80.0%, and the probability that a liberal strategy was associated with at least 1 more heart failure event per 100 treated was between 13.3% and 29.3%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n This post hoc analysis of a randomized clinical trial of patients with MI and anemia suggests that a liberal transfusion strategy was associated with a lower risk of 30-day death or MI, outweighing the increased risk of heart failure. Consistent with guideline recommendations and according to patients\u2019 values and clinician risk assessment, a liberal transfusion strategy may be reasonable.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT02981407<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.24991","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:30:37Z","timestamp":1785166237000},"page":"e2624991","source":"Crossref","is-referenced-by-count":0,"title":["Restrictive vs Liberal Transfusion Strategy After Myocardial Infarction"],"prefix":"10.1001","volume":"9","author":[{"given":"Marnie","family":"Bertolet","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois Martin","family":"Carrier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care Division, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Department of Medicine, Critical Care Division, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Department of Anesthesiology and Pain Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Glynn","sequence":"additional","affiliation":[{"name":"National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland (retired)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Dawn","family":"Abbott","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brown University and Lifespan Cardiovascular Institute, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Defilippis","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabassome","family":"Simon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), Paris, France"},{"name":"Department of Pharmacology, H\u00f4pital Saint Antoine and Clinical Research Platform of Paris (URC-CRB-CRC), Paris, France"},{"name":"FACT (French Alliance for Cardiovascular Trials), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher 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