{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:59Z","timestamp":1786724879609,"version":"build-2736575974"},"reference-count":31,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Accurate histologic diagnosis of pelvic tumors is essential for guiding appropriate management but often requires diagnostic surgery, which is associated with morbidity and treatment delays. Ultrasonography-guided core needle biopsy offers a minimally invasive alternative that may reduce surgical risks while providing reliable diagnostic information.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess the safety and diagnostic adequacy of ultrasonography-guided core needle biopsy in patients with pelvic tumors and to evaluate diagnostic accuracy, patient experience, and pain levels associated with the procedure.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This prospective, multicenter cohort study was performed from May 26, 2021, to December 31, 2024, at 4 high-volume gynecologic oncology centers (Leuven, Belgium; Rome, Italy; Prague, Czech Republic; and Stockholm, Sweden), with follow-up at 6 weeks after the procedure. Consecutive patients aged 18 years or older with a pelvic tumor undergoing ultrasonography-guided core needle biopsy for diagnostic purposes or inclusion in academic trials were included, and follow-up data were available for all participants.<\/jats:p>\n <\/jats:sec>\n \n Exposure<\/jats:title>\n Ultrasonography-guided core needle biopsy performed via transvaginal, transrectal, or percutaneous approaches according to lesion location and clinical indication.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcomes were safety, as assessed by procedure-related complication rates within 6 weeks, and diagnostic adequacy of biopsy specimens. Secondary outcomes included diagnostic accuracy compared with subsequent surgical histology when available, patient-reported pain measured using a numeric rating scale (0-100), and overall patient experience assessed within 72 hours post procedure. Descriptive statistical and multivariable regression analyses were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 461 patients prospectively enrolled in the study, biopsies were performed on 463 lesions (transvaginal: 422 patients; median [IQR] age, 64 [53-73] years; transrectal: 11 patients; median [IQR] age, 78 [59-80] years; percutaneous: 30 patients; median [IQR] age, 58 [51-71] years). Procedure-related complications occurred in 60 patients (13.0%), all of which were minor; no patients required surgery or blood transfusion due to complications. Biopsy specimens were diagnostically adequate in 95.7% (95% CI, 93.4%-97.4%) of cases. In 166 cases with available subsequent surgical histology, diagnostic accuracy was 97.6% (95% CI, 93.9%-99.3%). Patient experience was favorable, with 378 of 402 patients (94.0%) rating their experience in the upper half of the scale. The median pain score was 20 (IQR, 10-50).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n This cohort study of patients undergoing ultrasonography-guided core needle biopsy of pelvic lesions found the procedure to be safe, diagnostically adequate, and well-tolerated. These findings support the procedure\u2019s broader implementation in selected patients to reduce the need for diagnostic surgery and associated morbidity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.29587","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:30:27Z","timestamp":1786721427000},"page":"e2629587","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonography-Guided Core Needle Biopsy in the Diagnostic Pathway of Pelvic Tumors"],"prefix":"10.1001","volume":"9","author":[{"given":"Stefan","family":"Timmerman","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium"},{"name":"Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven, Belgium"},{"name":"Department of Obstetrics and Gynaecology, Jessa Ziekenhuis, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Taliento","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium"},{"name":"Department of Obstetrics and Gynecology, University Hospital Ferrara, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"Haesen","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium"},{"name":"Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Dababou","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pozzati","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Quagliozzi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Moro","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"},{"name":"UniCamillus-International Medical University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Mascilini","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Testa","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"},{"name":"Dipartimento Universitario Scienze della Vita e Sanit\u00e0 Pubblica, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Fr\u00fchauf","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics, and Neonatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Kocian","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics, and Neonatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fischerova","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Obstetrics, and Neonatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Obstetrics and Gynecology, S\u00f6dersjukhuset, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fruscio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy"},{"name":"Unit\u00e0 Operativa di Ginecologia, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Ledger","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven, Leuven, 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