{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:20:57Z","timestamp":1788405657509,"version":"build-2803163510"},"reference-count":27,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among patients with nonmetastatic prostate cancer.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This study, nested in the Health Professionals Follow-Up Study, a cohort of male health professionals from across 50 US states ongoing since 1986, included participants with confirmed nonmetastatic prostate cancer between 1986 and January 2019, followed up through December 2022. Statistical analysis was conducted from July 2024 to May 2026.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Dietary data were collected every 4 years from validated food frequency questionnaires and used to estimate intake of saturated, polyunsaturated, monounsaturated, trans, plant, and animal fat after cancer diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Main outcomes were all-cause mortality and death from prostate cancer, other cancers, cardiovascular disease, and other causes during a median 12.8 years (IQR, 8.1-16.8 years) of follow-up through 2022. Hazard ratios (HRs) and 95% CIs from multivariable Cox proportional hazards regression and multivariate nutrient-density models examined associations with mortality, adjusting for demographic, epidemiologic, and clinical factors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 4884 patients with nonmetastatic prostate cancer, the mean (SD) age at diagnosis was 69.5 (6.9) years. During follow-up, 3040 deaths from any cause were confirmed. When comparing patients in the highest quintile of saturated fat consumption with those in the lowest quintile, higher postdiagnostic saturated fat intake was associated with greater all-cause (HR, 1.24 [95% CI, 1.05-1.47), cardiovascular (HR, 1.42 [95% CI, 1.02-1.98]), and other cancer mortality (HR, 1.42 [95% CI, 0.93-2.17]). Animal fat, a major source of saturated fats, was also positively associated with all-cause mortality (HR, 1.14 [95% CI, 0.97-1.33]), as well as deaths from other cancers (HR, 1.49 [95% CI, 1.00-2.21]). Replacing 10% of calories from animal fats with plant-based fats (HR, 0.84 [95% CI, 0.76-0.93]) and replacing 5% of calories from saturated fats with monounsaturated fats (HR, 0.80 [95% CI, 0.70-0.91]) was associated with a decrease in all-cause mortality. There were no associations between dietary fats and prostate cancer mortality.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of patients with nonmetastatic prostate cancer, saturated fats, including animal fats, were associated with greater all-cause mortality owing to deaths from cardiovascular disease and other cancers. Diets rich in monounsaturated and polyunsaturated fats and plant-based fats after prostate cancer diagnosis were associated with improved survival outcomes for patients. These findings support evidence-based recommendations for patients and clinicians around dietary fat consumption to improve survivorship outcomes in the clinical setting of nonmetastatic prostate cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.30693","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:00:29Z","timestamp":1788361229000},"page":"e2630693","source":"Crossref","is-referenced-by-count":1,"title":["Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer"],"prefix":"10.1001","volume":"9","author":[{"given":"Yiwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"Shanahan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Guard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Ji","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Research Institute of the McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Division of Urology, Department of Surgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Celia","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Research Institute of the McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Boufaied","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Research Institute of the McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane B.","family":"Vaselkiv","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binkai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Loeb","sequence":"additional","affiliation":[{"name":"Department of Urology and Population Health, New York University Langone Health, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Himbert","sequence":"additional","affiliation":[{"name":"Department of Cancer Population Sciences, Huntsman Cancer Institute, Salt Lake City, Utah"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Research Institute of the McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Division of Urology, Department of Surgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorelei A.","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Discovery Sciences, American Cancer Society, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"11","key":"zoi260842r1","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1093\/jnci\/djae135","article-title":"Prevalence of cancer survivors in the United States.","volume":"116","author":"Tonorezos","year":"2024","journal-title":"J Natl Cancer Inst"},{"key":"zoi260842r2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1130691","article-title":"Cardiovascular mortality by cancer risk stratification in patients with localized prostate cancer: a SEER-based study.","volume":"10","author":"Luo","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"17","key":"zoi260842r3","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1093\/jnci\/djs299","article-title":"Temporal trends in cause of death among Swedish and US men with prostate cancer.","volume":"104","author":"Epstein","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"zoi260842r4","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.clnu.2020.07.007","article-title":"Association between dietary fat intake and mortality from all-causes, cardiovascular disease, and cancer: a systematic review and meta-analysis of prospective cohort studies.","volume":"40","author":"Kim","year":"2021","journal-title":"Clin Nutr"},{"issue":"3","key":"zoi260842r5","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000000510","article-title":"Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association.","volume":"136","author":"Sacks","year":"2017","journal-title":"Circulation"},{"issue":"48","key":"zoi260842r6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032003","article-title":"Association of low-density lipoprotein cholesterol levels with the risk of mortality and cardiovascular events: a meta-analysis of cohort studies with 1,232,694 participants.","volume":"101","author":"Peng","year":"2022","journal-title":"Medicine (Baltimore)"},{"issue":"9","key":"zoi260842r7","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.3390\/nu11092059","article-title":"Cancer and Mediterranean diet: a review.","volume":"11","author":"Mentella","year":"2019","journal-title":"Nutrients"},{"issue":"8","key":"zoi260842r8","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s10552-015-0606-4","article-title":"Fat intake after prostate cancer diagnosis and mortality in the Physicians\u2019 Health Study.","volume":"26","author":"Van Blarigan","year":"2015","journal-title":"Cancer Causes Control"},{"issue":"14","key":"zoi260842r9","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1001\/jamainternmed.2013.6536","article-title":"Fat intake after diagnosis and risk of lethal prostate cancer and all-cause mortality.","volume":"173","author":"Richman","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"4","key":"zoi260842r10","doi-asserted-by":"publisher","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for total energy intake in epidemiologic studies.","volume":"65","author":"Willett","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"zoi260842r11","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/oxfordjournals.aje.a116211","article-title":"Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals.","volume":"135","author":"Rimm","year":"1992","journal-title":"Am J Epidemiol"},{"issue":"1","key":"zoi260842r12","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/aje\/kwad170","article-title":"Validity and reproducibility of a semiquantitative food frequency questionnaire for measuring intakes of foods and food groups.","volume":"193","author":"Gu","year":"2024","journal-title":"Am J Epidemiol"},{"issue":"11","key":"zoi260842r13","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1093\/oxfordjournals.aje.a117191","article-title":"Test of the National Death Index and Equifax Nationwide Death Search.","volume":"140","author":"Rich-Edwards","year":"1994","journal-title":"Am J Epidemiol"},{"issue":"9","key":"zoi260842r14","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1093\/aje\/kwq481","article-title":"Bias due to left truncation and left censoring in longitudinal studies of developmental and disease processes.","volume":"173","author":"Cain","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"6","key":"zoi260842r15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/oxfordjournals.aje.a009849","article-title":"Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements.","volume":"149","author":"Hu","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"8","key":"zoi260842r16","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1161\/CIRCRESAHA.118.313996","article-title":"Associations of monounsaturated fatty acids from plant and animal sources with total and cause-specific mortality in two US prospective cohort studies.","volume":"124","author":"Guasch-Ferr\u00e9","year":"2019","journal-title":"Circ Res"},{"issue":"8","key":"zoi260842r17","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1001\/jamainternmed.2016.2417","article-title":"Association of specific dietary fats with total and cause-specific mortality.","volume":"176","author":"Wang","year":"2016","journal-title":"JAMA Intern Med"},{"issue":"10","key":"zoi260842r18","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1001\/jamainternmed.2024.3799","article-title":"Plant and animal fat intake and overall and cardiovascular disease mortality.","volume":"184","author":"Zhao","year":"2024","journal-title":"JAMA Intern Med"},{"issue":"4","key":"zoi260842r19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1023\/A:1008913307947","article-title":"Dietary fat and prostate cancer survival.","volume":"10","author":"Meyer","year":"1999","journal-title":"Cancer Causes Control"},{"issue":"3","key":"zoi260842r20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/aje\/kwr520","article-title":"Dietary fatty acid intake and prostate cancer survival in \u00d6rebro County, Sweden.","volume":"176","author":"Epstein","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"6","key":"zoi260842r21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1158\/1940-6207.CAPR-14-0442","article-title":"Dietary patterns after prostate cancer diagnosis in relation to disease-specific and total mortality.","volume":"8","author":"Yang","year":"2015","journal-title":"Cancer Prev Res (Phila)"},{"issue":"15","key":"zoi260842r22","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.3390\/nu16152474","article-title":"Identifying the leading sources of saturated fat and added sugar in U.S. adults.","volume":"16","author":"Taylor","year":"2024","journal-title":"Nutrients"},{"issue":"23","key":"zoi260842r23","doi-asserted-by":"publisher","first-page":"e472","DOI":"10.1161\/CIR.0000000000001031","article-title":"2021 Dietary guidance to improve cardiovascular health: a scientific statement from the American Heart Association.","volume":"144","author":"Lichtenstein","year":"2021","journal-title":"Circulation"},{"issue":"3","key":"zoi260842r24","doi-asserted-by":"publisher","first-page":"512S","DOI":"10.1093\/ajcn\/70.3.512s","article-title":"The role of dietary fats in plant-based diets.","volume":"70","author":"Coulston","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"zoi260842r25","doi-asserted-by":"publisher","first-page":"198","DOI":"10.2337\/diaclin.33.4.198","article-title":"Legumes: health benefits and culinary approaches to increase intake.","volume":"33","author":"Polak","year":"2015","journal-title":"Clin Diabetes"},{"issue":"9","key":"zoi260842r27","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.33922","article-title":"Adherence to American Cancer Society guideline and mortality in men with nonmetastatic prostate cancer.","volume":"8","author":"Elahy","year":"2025","journal-title":"JAMA Netw Open"},{"key":"zoi260842r26","unstructured":"Fats in foods. American Heart Association. October 25, 2023. Accessed October 22, 2025. https:\/\/www.heart.org\/en\/healthy-living\/healthy-eating\/eat-smart\/fats\/fats-in-foods"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2853518\/zhang_2026_oi_260842_1787752185.24081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:00:30Z","timestamp":1788361230000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2853518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2026.30693","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}