{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:12Z","timestamp":1787761272912,"version":"build-2784847793"},"reference-count":55,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Centenarian lifespan extension is frequently accompanied by delayed onset of aging-associated diseases. Understanding the transgenerational patterns of this phenomenon is crucial for informing investigations of genetic and environmental factors that promote healthy aging.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate the extent and consistency with which centenarians\u2019 offspring exhibit delayed onset of death and age-associated morbidities as well as decreased risk of age-related morbidities across independent cohorts.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Three independent longitudinal cohorts were studied: LonGenity (2008-2024; New York City area), the New England Centenarian Study (NECS; 1995-2024; throughout the US), and the UK Biobank (2006-2022; throughout the UK). Participants were selected from the 3 studies based on their parental lifespan. Data were analyzed between July 2024 and June 2026.<\/jats:p>\n <\/jats:sec>\n \n Exposure<\/jats:title>\n Centenarians\u2019 offspring had at least 1 parent who reached age 100 years and were compared with control offspring of parents with shorter lifespans.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Differences in age at death and age at onset of 4 age-associated morbidities\u2014cardiovascular disease (CVD), cancer, hypertension, and stroke\u2014were evaluated within study cohorts using Cox proportional hazards regression modeling, estimating hazard ratios (HRs) and delays in expected age of incidence.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Combined, centenarians\u2019 offspring and control participants numbered 480 in LonGenity (median enrollment age, 74 years [range, 65-94 years]; 262 women [55%]; 245 offspring of centenarians [51%]), 1566 in NECS (median enrollment age, 71 years [range, 39-100 years]; 923 women [59%]; 1082 offspring of centenarians [69%]), and 1984 in the UK Biobank (median enrollment age, 65 years [range, 42-71 years]; 1006 women [51%]; 992 offspring of centenarians [50%]). Meta-analyses identified consistently reduced hazards for death, CVD, and hypertension, with aggregate HR estimates of 0.58 (95% CI, 0.41-0.81) for death, 0.67 (95% CI, 0.46-0.97) for CVD, and 0.68 (95% CI, 0.62-0.75) for hypertension, and delays of 3.12 years (95% CI, 0.96-5.28 years) for death and 5.21 years (95% CI, 2.13-8.29 years) for hypertension. Stroke hazards were reduced only in LonGenity (HR, 0.27 [95% CI, 0.09-0.81]) and NECS (HR, 0.41 [95% CI, 0.27-0.63]). No significant associations with cancer were identified.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of parental longevity, centenarians\u2019 offspring exhibited delayed onset of mortality and several morbidities as well as reduced age-associated risk for several morbidities. These findings support the value of using this group as a research model for identifying factors that may promote healthy aging and the suitability of parental longevity as a criterion in prospective studies of resilience.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.30964","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:31Z","timestamp":1787758231000},"page":"e2630964","source":"Crossref","is-referenced-by-count":0,"title":["Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts"],"prefix":"10.1001","volume":"9","author":[{"given":"Eric R.","family":"Reed","sequence":"first","affiliation":[{"name":"Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute for Aging Research, 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