{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:59:27Z","timestamp":1790092767935,"version":"4.0.1"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>DNL343 is a brain-penetrant small molecule that acts as an activator of eukaryotic translation initiation factor 2B (eIF2b), designed to inhibit the integrated stress response. A prior phase 1B trial of DNL343 in amyotrophic lateral sclerosis (ALS) provided evidence of a favorable safety profile, central nervous system penetrance, and target engagement based on integrated stress response biomarkers in blood and cerebrospinal fluid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of a 200-mg formulation of DNL343 given once daily in individuals living with ALS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>DNL343 was evaluated as a regimen of the HEALEY ALS Platform Trial, a double-blind, multiregimen, placebo-controlled randomized clinical trial conducted at 74 centers in the US between May 24, 2023, and May 22, 2025. Eligible participants were randomized in a 3:1 ratio to receive DNL343 or matching placebo, with both groups enrolling concurrently. The analysis included shared randomized participants receiving placebo from an additional regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>The study drug was administered for a placebo-controlled duration of 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>The primary analysis was a bayesian shared parameter model of function and survival that provided an integrated estimate of the relative rate of disease progression among participants receiving DNL343 relative to placebo. The model had components for function and survival linked through an integrated estimate of disease slowing in treatment relative to controls across the 2 outcomes (denoted as the disease rate ratio [DRR]). Several safety, secondary, and exploratory end points were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 259 screenings were completed in this regimen; 249 participants met eligibility and were randomized to DNL343 (n = 186) and regimen-specific placebo (n = 63), with an additional 76 participants from a concurrent regimen receiving placebo included for a total of 139 shared placebo participants (325 participants, with 196 (60.3%) male and mean [SD] age of 59.3 [11.5] years). The estimated median DRR common to the ALS Functional Rating Scale\u2013Revised and survival was 1.04 (95% credible interval, 0.83-1.32; probability of DRR &amp;amp;lt;1, 0.37). Secondary outcome measures were not statistically different between the DNL343 and placebo groups. Overall, the incidence rates of adverse events were similar in participants receiving DNL343 and placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this randomized clinical trial, despite the relevance of the eIF2b activation pathway in ALS disease biology and supporting evidence of proof of mechanism and optimal dose selection in a prior phase 1B ALS clinical trial, 200-mg\/d DNL343 did not show evidence of slowing disease progression in ALS, highlighting the need for alternative therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov Identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05842941\">NCT05842941<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.34809","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:00:36Z","timestamp":1790089236000},"page":"e2634809","source":"Crossref","is-referenced-by-count":0,"title":["DNL343 and Disease Progression in Amyotrophic Lateral Sclerosis"],"prefix":"10.1001","volume":"9","author":[{"given":"Sabrina","family":"Paganoni","sequence":"first","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"},{"name":"Spaulding Rehabilitation Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori B.","family":"Chibnik","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Quintana","sequence":"additional","affiliation":[{"name":"Berry Consultants, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Macklin","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Detry","sequence":"additional","affiliation":[{"name":"Berry Consultants, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Vestrucci","sequence":"additional","affiliation":[{"name":"Berry Consultants, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Paulon","sequence":"additional","affiliation":[{"name":"Berry Consultants, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"McGlothlin","sequence":"additional","affiliation":[{"name":"Berry Consultants, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Wang","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Walk","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Elman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Chase","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Heyd","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittney","family":"Harkey","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Shefner","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Scirocco","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gale","family":"Kittle","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"Hall","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Ho","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Jawdat","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Fairway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafeeq","family":"Ladha","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Nova Southeastern University, Davie, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rivner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Augusta University, Augusta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Felice","sequence":"additional","affiliation":[{"name":"Hospital for Special Care, New Britain, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Katz","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senda","family":"Ajroud-Driss","sequence":"additional","affiliation":[{"name":"The Ken and Ruth Davee Department of Neurology, Neuromuscular Disease, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Fee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rosow","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Quick","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daragh","family":"Heitzman","sequence":"additional","affiliation":[{"name":"Texas Neurology, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Section of Neuromuscular Medicine, University of Colorado Anschutz, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Maragakis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Goutman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Neurology, Loma Linda University School of Medicine, Loma Linda, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Benatar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuromuscular Division, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Swenson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Dedick","family":"Connors","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Center, Hackensack Meridian School of Medicine, Hackensack, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Shroff","sequence":"additional","affiliation":[{"name":"Methodist Neurological Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bedlack","sequence":"additional","affiliation":[{"name":"Department of Neurology, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney E.","family":"McIlduff","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hweii Amy","family":"Chen","sequence":"additional","affiliation":[{"name":"University of South Florida, College of Medicine, Tampa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Americo M.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Walsh","sequence":"additional","affiliation":[{"name":"Lehigh Valley Health Network, Allentown, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Peltier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hristelina","family":"Ilieva","sequence":"additional","affiliation":[{"name":"Jefferson Weinberg ALS Center, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Kushlaf","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said R.","family":"Beydoun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine, University of Southern California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett","family":"Myers","sequence":"additional","affiliation":[{"name":"Dent Neurologic Institute, Amherst, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximena","family":"Arcila-Londono","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Heiman-Patterson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Elliott","sequence":"additional","affiliation":[{"name":"Swedish Medical Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Whitesell","sequence":"additional","affiliation":[{"name":"Saint Alphonsus Regional Medical Center, Boise, Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfiq","family":"Al-Lahham","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Virginia, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Olney","sequence":"additional","affiliation":[{"name":"Providence ALS Clinic, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Baer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania, Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlayne","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Science Center, San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eufrosina","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine, SUNY (State University of New York) Upstate, Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Caress","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Kuenzler","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakti","family":"Nayar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Georgetown University, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Kasarskis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Neurology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summer","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret Ayo","family":"Owegi","sequence":"additional","affiliation":[{"name":"University of Massachusetts, Worcester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Wymer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly G.","family":"Gwathmey","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University, Henrico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Erickson","sequence":"additional","affiliation":[{"name":"Essentia Health, Duluth, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Alameda","sequence":"additional","affiliation":[{"name":"Holy Cross Hospital, Fort Lauderdale, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Bodkin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Indiana University, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Wu","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Los Angeles Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Martinez-Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Twydell","sequence":"additional","affiliation":[{"name":"Corewell Health, Grand Rapids, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsy","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Bayat","sequence":"additional","affiliation":[{"name":"George Washington University, Medical Faculty Associates Inc, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Rezania","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Usman","sequence":"additional","affiliation":[{"name":"Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Atrium Health, North Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanthi","family":"Kovvuru","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Jennings","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Garza-Meilandt","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo","family":"Maciuca","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac V.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Tamuly","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erden","family":"Eren","sequence":"additional","affiliation":[{"name":"Denali Therapeutics Inc, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merit E.","family":"Cudkowicz","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suma","family":"Babu","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"HEALEY ALS Platform Trial Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Donahue","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Wun","family":"Chen","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kantor","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Caporaletti","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"McCaffrey","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Scalia","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimin","family":"Shah","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazala","family":"Hayat","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Pattee","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Zilliox","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Johnson","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine","family":"Farmakidis","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jourdan","family":"Milliard","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bowser","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Lopes","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Barnes","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liberty","family":"Jenkins","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sufit","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Szymanski","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shrilla","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Malcolm","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lomen-Hoerth","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Goslinga","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kang","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madina","family":"Tugizova","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sampognaro","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kolb","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Heintzman","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Martin","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora L.","family":"Clawson","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpa","family":"Uchil","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Riley","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinae","family":"Arneklev","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Quigley","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Carberry","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Nance","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian P","family":"Thomas","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seward","family":"Rutkove","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrica","family":"Farias","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Vu","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Murray","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Guerra Hernandez","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Piccione","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pariwat","family":"Thaisetthawatkul","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Romano","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Davis","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Pasinelli","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lewis","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Janecek","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Darki","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Rojas","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Steijlen","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Zaman","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Deboo","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ivanick","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Guthrie","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lacomis","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jones","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hadler","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Brown","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Bazan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Quinn","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Maiser","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Bhavaraju-Sanka","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny A.","family":"Meyer","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Cartwright","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Rad","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimish","family":"Thakore","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabeen","family":"Mahuwala","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishakhadatta (Vish)","family":"Mathur Kumaraswamy","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Grogan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Su","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh","family":"Mamarabadi","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bromberg","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Brown Jr.","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Daniello","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Mullen","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"McNeely","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihua","family":"Fan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Treidler","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Staff","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Yasek","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Roos","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Renkl","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Oskarsson","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Diaz-Abad","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Arroyave","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Barlow","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevive","family":"Changkuon","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Cirino","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Coleman","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Dagostino","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Deignan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Deirmendjian","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"De Mattos","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"DiStefano","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Drake","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Estes","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precious","family":"Figueroa-Szostek","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abaigeal M.","family":"Ford","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Garozzo","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Hasenoehrl","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Henrique","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Henrique","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hurwitz","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Igne","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Irwin","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Jentoft","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boglarka","family":"Jordan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Katsovskiy","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kharakozova","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Kolvek","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Korin","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuong","family":"La","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Li","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Mazina","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Ostrow","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Palillo","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Patel","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janae","family":"Patterson","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh","family":"Phan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla","family":"Popel","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Sanjana","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Small","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Stimpson","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia M.","family":"Tamburello","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tarasenko","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Thomas","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tustison","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emem","family":"Udo","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasha","family":"Vigneswaran","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra","family":"Wahab","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Weiss Sadan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Whitworth","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Wong","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Wright","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Connolly","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Felix","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karly","family":"Garrett","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Stepler","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"De La Rosa Garcia","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Khan","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"McGlaughlin","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Ghali","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyinkansola","family":"Lawal","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Nelson","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Pabon","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Rede","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Sporn","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Bill","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Clark","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Kamp","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Kennedy","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Fannon","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Mark","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Horbovetz","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McGarry","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Torti","sequence":"additional","affiliation":[{"name":"for the HEALEY ALS Platform Trial Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"zoi260939r1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.92173","article-title":"DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.","volume":"12","author":"Yulyaningsih","year":"2024","journal-title":"Elife"},{"issue":"10","key":"zoi260939r2","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response.","volume":"17","author":"Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep"},{"issue":"6489","key":"zoi260939r3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: from mechanism to disease.","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"issue":"Pt 12","key":"zoi260939r4","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1093\/brain\/awm190","article-title":"Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis.","volume":"130","author":"Ilieva","year":"2007","journal-title":"Brain"},{"issue":"3","key":"zoi260939r5","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.nbd.2009.08.013","article-title":"Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice.","volume":"36","author":"Ito","year":"2009","journal-title":"Neurobiol Dis"},{"issue":"2","key":"zoi260939r6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00401-005-1038-0","article-title":"The unfolded protein response is activated in Alzheimer\u2019s disease.","volume":"110","author":"Hoozemans","year":"2005","journal-title":"Acta Neuropathol"},{"issue":"4","key":"zoi260939r7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/01.jnen.0000218445.30535.6f","article-title":"Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo.","volume":"65","author":"Unterberger","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"zoi260939r8","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","article-title":"The unfolded protein response is activated in pretangle neurons in Alzheimer\u2019s disease hippocampus.","volume":"174","author":"Hoozemans","year":"2009","journal-title":"Am J Pathol"},{"key":"zoi260939r9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/2051-5960-1-31","article-title":"The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer\u2019s disease.","volume":"1","author":"Stutzbach","year":"2013","journal-title":"Acta Neuropathol Commun"},{"issue":"11","key":"zoi260939r10","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1056\/NEJMra2215795","article-title":"Messenger RNA translation defects in neurodegenerative diseases.","volume":"388","author":"Storkebaum","year":"2023","journal-title":"N Engl J Med"},{"issue":"8","key":"zoi260939r11","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration.","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"7","key":"zoi260939r12","doi-asserted-by":"publisher","first-page":"5758","DOI":"10.1021\/acs.jmedchem.3c02422","article-title":"Discovery of DNL343: a potent, selective, and brain-penetrant eIF2B activator designed for the treatment of neurodegenerative diseases.","volume":"67","author":"Craig","year":"2024","journal-title":"J Med Chem"},{"issue":"8","key":"zoi260939r13","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1179\/016164107X229803","article-title":"Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis.","volume":"29","author":"Nagata","year":"2007","journal-title":"Neurol Res"},{"issue":"1","key":"zoi260939r14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41467-017-02495-z","article-title":"C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2a phosphorylation.","volume":"9","author":"Cheng","year":"2018","journal-title":"Nat Commun"},{"key":"zoi260939r15","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nbd.2018.05.009","article-title":"Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress.","volume":"116","author":"Sonobe","year":"2018","journal-title":"Neurobiol Dis"},{"issue":"2","key":"zoi260939r16","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809423","article-title":"Repeat-associated non-AUG translation in C9orf72-ALS\/FTD is driven by neuronal excitation and stress.","volume":"11","author":"Westergard","year":"2019","journal-title":"EMBO Mol Med"},{"issue":"2","key":"zoi260939r17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ng.2853","article-title":"Therapeutic modulation of eIF2a phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.","volume":"46","author":"Kim","year":"2014","journal-title":"Nat Genet"},{"key":"zoi260939r18","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20725","article-title":"Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.","volume":"6","author":"Larhammar","year":"2017","journal-title":"Elife"},{"issue":"206","key":"zoi260939r19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006767","article-title":"Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.","volume":"5","author":"Moreno","year":"2013","journal-title":"Sci Transl Med"},{"key":"zoi260939r20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42940","article-title":"eIF2B activator prevents neurological defects caused by a chronic integrated stress response.","volume":"8","author":"Wong","year":"2019","journal-title":"Elife"},{"issue":"1","key":"zoi260939r21","doi-asserted-by":"publisher","first-page":"7690","DOI":"10.1038\/s41467-025-63031-y","article-title":"Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.","volume":"16","author":"Flores","year":"2025","journal-title":"Nat Commun"},{"issue":"11","key":"zoi260939r22","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/s43587-024-00740-x","article-title":"Lessons from the HEALEY adaptive platform trial in amyotrophic lateral sclerosis.","volume":"4","author":"Paganoni","year":"2024","journal-title":"Nat Aging"},{"issue":"2","key":"zoi260939r23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/mus.28442","article-title":"Operational development and launch of an adaptive platform trial in amyotrophic lateral sclerosis: processes and learnings from the first four regimens of the HEALEY ALS Platform Trial.","volume":"72","author":"Harkey","year":"2025","journal-title":"Muscle Nerve"},{"issue":"3","key":"zoi260939r24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/ana.26714","article-title":"Design and statistical innovations in a platform trial for amyotrophic lateral sclerosis.","volume":"94","author":"Quintana","year":"2023","journal-title":"Ann Neurol"},{"issue":"2","key":"zoi260939r25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/ana.26285","article-title":"Adaptive platform trials to transform amyotrophic lateral sclerosis therapy development.","volume":"91","author":"Paganoni","year":"2022","journal-title":"Ann Neurol"},{"issue":"20","key":"zoi260939r26","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"issue":"22","key":"zoi260939r28","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1001\/jama.2025.4347","article-title":"CONSORT 2025 Statement: Updated Guideline for Reporting Randomized Trials.","volume":"333","author":"Hopewell","year":"2025","journal-title":"JAMA"},{"issue":"5","key":"zoi260939r29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis.","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"1-2","key":"zoi260939r30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function.","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"issue":"1","key":"zoi260939r31","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1080\/17482960600888156","article-title":"Excellent inter-rater, intra-rater, and telephone-administered reliability of the ALSFRS-R in a multicenter clinical trial.","volume":"8","author":"Kaufmann","year":"2007","journal-title":"Amyotroph Lateral Scler"},{"issue":"1","key":"zoi260939r32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/14660820510027107","article-title":"Rating the severity of ALS by caregivers over the telephone using the ALSFRS-R.","volume":"6","author":"Kasarskis","year":"2005","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"7","key":"zoi260939r33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4155\/cli.14.52","article-title":"Outcome measures in amyotrophic lateral sclerosis clinical trials.","volume":"4","author":"Paganoni","year":"2014","journal-title":"Clin Investig (Lond)"},{"issue":"5","key":"zoi260939r34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1474-4422(18)30089-9","article-title":"Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model.","volume":"17","author":"Westeneng","year":"2018","journal-title":"Lancet Neurol"},{"issue":"11","key":"zoi260939r35","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/(SICI)1097-0258(19990615)18:11<1341::AID-SIM129>3.0.CO;2-7","article-title":"Combining mortality and longitudinal measures in clinical trials.","volume":"18","author":"Finkelstein","year":"1999","journal-title":"Stat Med"},{"key":"zoi260939r27","unstructured":"NEALS single institutional review board. Accessed May 18, 2026. https:\/\/neals.org\/als-researchers\/neals-single-institutional-review-board-cirb\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2854318\/paganoni_2026_oi_260939_1789416856.4776.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:00:39Z","timestamp":1790089239000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2854318"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2026.34809","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}