{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:58:14Z","timestamp":1790956694997,"version":"4.1.0"},"reference-count":65,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Iatrogenic menopause is common, but its long-term cardiovascular consequences remain uncertain, particularly by age at menopause.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To quantify associations between iatrogenic menopause and cardiovascular morbidity and mortality and evaluate whether age at iatrogenic menopause is a modifier.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n In this systematic review and meta-analysis, Scopus, MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, and PsycINFO were searched from January 2004 to March 2026.<\/jats:p>\n <\/jats:sec>\n \n Study Selection<\/jats:title>\n Observational studies and randomized clinical trials reporting cardiovascular morbidity or mortality among women with iatrogenic menopause before natural menopause age compared with naturally menopausal or age-matched controls were included.<\/jats:p>\n <\/jats:sec>\n \n Data Extraction and Synthesis<\/jats:title>\n Data were extracted in duplicate by 2 independent reviewers, with consensus resolution. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Primary outcomes were cardiovascular morbidity, cardiovascular and all-cause mortality, and a composite of cardiovascular morbidity and cardiovascular mortality, quantified as random-effects pooled hazard ratios (PHRs) with 95% CIs, irrespective of heterogeneity and with age at menopause as a moderator. Meta-regression estimates were clustered by source cohort.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 14\u202f409 records, 36 studies were included with 2\u202f617\u202f942 women (mean [SD] age, 55.52 [12.41] years for the iatrogenic menopause cohort and 45.58 [16.02] years for comparators); median follow-up was 16.0 years (range, 4.8-36.0 years). Iatrogenic menopause vs comparators was associated with higher risk of all-cause mortality (PHR, 1.08; 95% CI, 1.01-1.16), cardiovascular events (PHR, 1.25; 95% CI, 1.12-1.39), coronary heart disease (PHR, 1.48; 95% CI, 1.07-2.03), and stroke (PHR, 1.22; 95% CI, 1.15-1.28). Mortality excesses were confined to iatrogenic menopause before age 45 years (cardiovascular mortality: PHR, 1.20 [95% CI, 1.04-1.37]; all-cause mortality: PHR, 1.15 [95% CI, 1.06-1.25]), with null estimates at or after age 45 years (cardiovascular mortality: PHR, 0.95 [95% CI, 0.81-1.11]; all-cause mortality: PHR, 0.99 [95% CI, 0.89-1.09]). In a post hoc meta-regression on the composite outcome, each increasing 5-year increment in age at iatrogenic menopause was associated with lower risk (HR, 0.89; 95% CI, 0.83-0.97) based on 37 estimates from 11 independent populations.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this study, iatrogenic menopause was associated with higher cardiovascular morbidity, most consistently stroke, and with cardiovascular and all-cause mortality excesses before age 45 years at menopause. Older age at iatrogenic menopause was associated with progressively lower risk of cardiovascular morbidity and mortality, supporting a period of elevated risk before age 45 years rather than a single threshold age.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.37545","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:30:26Z","timestamp":1790955026000},"page":"e2637545","source":"Crossref","is-referenced-by-count":0,"title":["Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality"],"prefix":"10.1001","volume":"9","author":[{"given":"Eleni","family":"Armeni","sequence":"first","affiliation":[{"name":"Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom"},{"name":"Royal Free Hospital NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipek Betul Ozcivit","family":"Erkan","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Institute of Graduate Studies, Istanbul University\u2013Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punith","family":"Kempegowda","sequence":"additional","affiliation":[{"name":"Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom"},{"name":"Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"issue":"11","key":"zoi261011r1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.mayocp.2016.08.002","article-title":"Accelerated accumulation of multimorbidity after bilateral oophorectomy: a population-based cohort study.","volume":"91","author":"Rocca","year":"2016","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"zoi261011r2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1258\/mi.2008.008016","article-title":"Prophylactic oophorectomy in premenopausal women and long-term health.","volume":"14","author":"Shuster","year":"2008","journal-title":"Menopause Int"},{"issue":"4","key":"zoi261011r3","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3109\/13697137.2015.1020484","article-title":"Long-term health consequences of premature or early menopause and considerations for management.","volume":"18","author":"Faubion","year":"2015","journal-title":"Climacteric"},{"issue":"3","key":"zoi261011r4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ecl.2015.05.003","article-title":"Surgical menopause.","volume":"44","author":"Rodriguez","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"zoi261011r5","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1097\/AOG.0000000000002296","article-title":"Practice Bulletin No 182: hereditary breast and ovarian cancer syndrome.","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"8","key":"zoi261011r6","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1093\/humrep\/deaa124","article-title":"Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies.","volume":"35","author":"Zhu","year":"2020","journal-title":"Hum Reprod"},{"issue":"9","key":"zoi261011r7","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1093\/humrep\/deac137","article-title":"Menopause, hysterectomy, menopausal hormone therapy and cause-specific mortality: cohort study of UK Biobank participants.","volume":"37","author":"Xu","year":"2022","journal-title":"Hum Reprod"},{"issue":"13","key":"zoi261011r8","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.3390\/jcm12134435","article-title":"Association between menopause, postmenopausal hormone therapy and metabolic syndrome.","volume":"12","author":"Ou","year":"2023","journal-title":"J Clin Med"},{"issue":"1","key":"zoi261011r9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.fertnstert.2011.10.004","article-title":"Bilateral oophorectomy is not associated with increased mortality: the California Teachers Study.","volume":"97","author":"Duan","year":"2012","journal-title":"Fertil Steril"},{"issue":"11","key":"zoi261011r10","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1007\/s11912-022-01309-w","article-title":"Cardiovascular disease in adult cancer survivors: a review of current evidence, strategies for prevention and management, and future directions for cardio-oncology.","volume":"24","author":"Muhandiramge","year":"2022","journal-title":"Curr Oncol Rep"},{"issue":"4","key":"zoi261011r11","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jaccao.2025.03.008","article-title":"Risk of cardiovascular disease in cancer survivors after systemic treatment: a population-based cohort study.","volume":"7","author":"Mulder","year":"2025","journal-title":"JACC CardioOncol"},{"key":"zoi261011r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103274","article-title":"Risk of cardiovascular disease among cancer survivors: systematic review and meta-analysis.","volume":"84","author":"Li","year":"2025","journal-title":"EClinicalMedicine"},{"issue":"1","key":"zoi261011r13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ajog.2023.06.043","article-title":"Long-term outcomes of hysterectomy with bilateral salpingo-oophorectomy: a systematic review and meta-analysis.","volume":"230","author":"Hassan","year":"2024","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"zoi261011r14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ygyno.2008.02.025","article-title":"Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2).","volume":"109","author":"D\u00f8rum","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"4","key":"zoi261011r15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/aogs.14531","article-title":"All-cause and cardiovascular mortality after hysterectomy and oophorectomy in a large cohort (HUNT2).","volume":"102","author":"Michelsen","year":"2023","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"5","key":"zoi261011r16","doi-asserted-by":"publisher","first-page":"723.e1","DOI":"10.1016\/j.ajog.2020.04.037","article-title":"Hysterectomy with and without oophorectomy and all-cause and cause-specific mortality.","volume":"223","author":"Tuesley","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"zoi261011r17","doi-asserted-by":"publisher","first-page":"83.e1","DOI":"10.1016\/j.ajog.2018.10.002","article-title":"Hysterectomy status and all-cause mortality in a 21-year Australian population-based cohort study.","volume":"220","author":"Wilson","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"zoi261011r18","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/GME.0000000000000118","article-title":"Long-term overall and disease-specific mortality associated with benign gynecologic surgery performed at different ages.","volume":"21","author":"Gierach","year":"2014","journal-title":"Menopause"},{"issue":"12","key":"zoi261011r19","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1161\/01.CIR.0000159344.21672.FD","article-title":"Risk of cardiovascular disease by hysterectomy status, with and without oophorectomy: the Women\u2019s Health Initiative observational study.","volume":"111","author":"Howard","year":"2005","journal-title":"Circulation"},{"issue":"10","key":"zoi261011r20","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.1161\/STROKEAHA.121.037305","article-title":"Risks of stroke and heart disease following hysterectomy and oophorectomy in Chinese premenopausal women.","volume":"53","author":"Poorthuis","year":"2022","journal-title":"Stroke"},{"issue":"1","key":"zoi261011r21","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/cen.15136","article-title":"Is early menopause a different entity from premature ovarian insufficiency?","volume":"102","author":"Anagnostis","year":"2025","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"zoi261011r22","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/heartjnl-2024-324602","article-title":"Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study.","volume":"111","author":"Pant","year":"2025","journal-title":"Heart"},{"issue":"1","key":"zoi261011r23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.24095\/hpcdp.34.1.05","article-title":"Prevalence of self-reported hysterectomy among Canadian women, 2000\/2001-2008.","volume":"34","author":"Stankiewicz","year":"2014","journal-title":"Chronic Dis Inj Can"},{"issue":"10","key":"zoi261011r24","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/aogs.13182","article-title":"Hysterectomy trends in Australia, 2000-2001 to 2013-2014: joinpoint regression analysis.","volume":"96","author":"Wilson","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"5","key":"zoi261011r25","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1097\/AOG.0b013e3181b9d222","article-title":"Nationwide use of laparoscopic hysterectomy compared with abdominal and vaginal approaches.","volume":"114","author":"Jacoby","year":"2009","journal-title":"Obstet Gynecol"},{"key":"zoi261011r26","doi-asserted-by":"publisher","first-page":"j372","DOI":"10.1136\/bmj.j372","article-title":"Removal of all ovarian tissue versus conserving ovarian tissue at time of hysterectomy in premenopausal patients with benign disease: study using routine data and data linkage.","volume":"356","author":"Mytton","year":"2017","journal-title":"BMJ"},{"issue":"25","key":"zoi261011r28","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1016\/j.jacc.2024.04.028","article-title":"Addressing the global burden of cardiovascular disease in women: JACC state-of-the-art review.","volume":"83","author":"Vervoort","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"zoi261011r29","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials.","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"3","key":"zoi261011r30","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pky034","article-title":"Mortality and risk of cancer after prophylactic bilateral oophorectomy in women with a family history of cancer.","volume":"2","author":"Abildgaard","year":"2018","journal-title":"J Natl Cancer Inst Cancer Spectr"},{"issue":"6","key":"zoi261011r31","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1097\/GME.0000000000001522","article-title":"Family history of premature myocardial infarction modifies the associations between bilateral oophorectomy and cardiovascular disease mortality in a US national cohort of postmenopausal women.","volume":"27","author":"Appiah","year":"2020","journal-title":"Menopause"},{"issue":"4","key":"zoi261011r32","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1093\/ije\/dyz016","article-title":"Association of menopausal characteristics and risk of coronary heart disease: a pan-European case-cohort analysis.","volume":"48","author":"Dam","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"3","key":"zoi261011r33","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ygyno.2021.06.022","article-title":"Risk of cardiovascular disease among women carrying BRCA mutations after risk-reducing bilateral salpingo-oophorectomy: a population-based study.","volume":"162","author":"do Valle","year":"2021","journal-title":"Gynecol Oncol"},{"issue":"25","key":"zoi261011r34","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1016\/j.jacc.2018.10.030","article-title":"Cardiovascular disease risk after treatment-induced premature ovarian insufficiency in female survivors of Hodgkin lymphoma.","volume":"72","author":"Krul","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"zoi261011r35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/gme.0b013e31818888f7","article-title":"Increased cardiovascular mortality after early bilateral oophorectomy.","volume":"16","author":"Rivera","year":"2009","journal-title":"Menopause"},{"issue":"10","key":"zoi261011r36","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/S1470-2045(06)70869-5","article-title":"Survival patterns after oophorectomy in premenopausal women: a population-based cohort study.","volume":"7","author":"Rocca","year":"2006","journal-title":"Lancet Oncol"},{"key":"zoi261011r37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.maturitas.2022.06.011","article-title":"Increased mortality and non-cancer morbidity risk may be associated with early menopause and varies with aetiology: an exploratory population-based study using data-linkage.","volume":"164","author":"Thong","year":"2022","journal-title":"Maturitas"},{"issue":"3","key":"zoi261011r38","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/GME.0000000000002314","article-title":"Age at natural or surgical menopause, all-cause mortality, and lifespan among postmenopausal women in the United States.","volume":"31","author":"Xing","year":"2024","journal-title":"Menopause"},{"issue":"12","key":"zoi261011r39","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.2337\/dc15-1434","article-title":"Androgens, bilateral oophorectomy, and cardiovascular disease mortality in postmenopausal women with and without diabetes: the Study of Osteoporotic Fractures.","volume":"38","author":"Appiah","year":"2015","journal-title":"Diabetes Care"},{"issue":"7","key":"zoi261011r40","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1089\/jwh.2022.0207","article-title":"Hysterectomy with and without oophorectomy, tubal ligation, and risk of cardiovascular disease in the Nurses\u2019 Health Study II.","volume":"32","author":"Farland","year":"2023","journal-title":"J Womens Health (Larchmt)"},{"issue":"6","key":"zoi261011r41","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/eurheartj\/ehq477","article-title":"Hysterectomy and risk of cardiovascular disease: a population-based cohort study.","volume":"32","author":"Ingelsson","year":"2011","journal-title":"Eur Heart J"},{"issue":"1","key":"zoi261011r42","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/GME.0000000000001873","article-title":"Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study.","volume":"29","author":"Olesen","year":"2021","journal-title":"Menopause"},{"issue":"24","key":"zoi261011r43","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1001\/jama.2019.19191","article-title":"Association of premature natural and surgical menopause with incident cardiovascular disease.","volume":"322","author":"Honigberg","year":"2019","journal-title":"JAMA"},{"issue":"2","key":"zoi261011r44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4103\/ijem.IJEM_620_17","article-title":"Assessment of cardiovascular risk in natural and surgical menopause.","volume":"22","author":"Abbas","year":"2018","journal-title":"Indian J Endocrinol Metab"},{"issue":"1","key":"zoi261011r45","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3109\/13697137.2010.481735","article-title":"Predictors for metabolic syndrome in perimenopausal and postmenopausal Thai women.","volume":"14","author":"Indhavivadhana","year":"2011","journal-title":"Climacteric"},{"issue":"1","key":"zoi261011r46","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1186\/s12905-024-03452-x","article-title":"Type of menopause, age of menopause and cardiovascular disease: a cross-sectional study based on data from Rafsanjan Cohort Study.","volume":"24","author":"Jamali","year":"2024","journal-title":"BMC Womens Health"},{"issue":"2","key":"zoi261011r47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.fertnstert.2004.01.034","article-title":"Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause.","volume":"82","author":"Mack","year":"2004","journal-title":"Fertil Steril"},{"issue":"1","key":"zoi261011r48","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijgo.2009.03.016","article-title":"Compared effects of surgical and natural menopause on climacteric symptoms, osteoporosis, and metabolic syndrome.","volume":"106","author":"Ozdemir","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"zoi261011r49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/gme.0b013e3181e5046d","article-title":"Comparison of the effects of surgical and natural menopause on carotid intima media thickness, osteoporosis, and homocysteine levels.","volume":"18","author":"\u00d6zkaya","year":"2011","journal-title":"Menopause"},{"issue":"2","key":"zoi261011r50","doi-asserted-by":"publisher","first-page":"179","DOI":"10.31083\/j.ceog.2020.02.5037","article-title":"The impact of surgical menopause on metabolic syndrome, bone mineral density, and vasomotor symptoms.","volume":"47","author":"Tuysuzoglu","year":"2020","journal-title":"Clinical and Experimental Obstetrics & Gynecology"},{"issue":"1","key":"zoi261011r51","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1530\/EJE-20-1275","article-title":"Premature ovarian failure after childhood cancer and risk of metabolic syndrome: a cross-sectional analysis.","volume":"185","author":"Netterlid","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"4 Pt 1","key":"zoi261011r52","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/gme.0b013e31816d5b1c","article-title":"Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women\u2019s Health Initiative coronary artery calcium study.","volume":"15","author":"Allison","year":"2008","journal-title":"Menopause"},{"issue":"7","key":"zoi261011r53","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1097\/GME.0000000000002192","article-title":"The association of hysterectomy with or without ovarian conservation with subclinical atherosclerosis progression in healthy postmenopausal women.","volume":"30","author":"Chen","year":"2023","journal-title":"Menopause"},{"issue":"4","key":"zoi261011r54","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3109\/13697137.2013.856400","article-title":"Does metabolic syndrome or its components differ in naturally and surgically menopausal women?","volume":"17","author":"Farahmand","year":"2014","journal-title":"Climacteric"},{"issue":"11","key":"zoi261011r55","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1097\/GME.0000000000000919","article-title":"The association of surgical versus natural menopause with future left ventricular structure and function: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.","volume":"24","author":"Appiah","year":"2017","journal-title":"Menopause"},{"key":"zoi261011r56","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078784","article-title":"Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial.","volume":"387","author":"Johansson","year":"2024","journal-title":"BMJ"},{"issue":"6","key":"zoi261011r57","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.ihj.2025.08.001","article-title":"Cardiovascular outcomes of bilateral oophorectomy: a systematic review and meta-analysis.","volume":"77","author":"Attachaipanich","year":"2025","journal-title":"Indian Heart J"},{"issue":"11","key":"zoi261011r58","doi-asserted-by":"publisher","first-page":"e553","DOI":"10.1016\/S2468-2667(19)30155-0","article-title":"Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data.","volume":"4","author":"Zhu","year":"2019","journal-title":"Lancet Public Health"},{"issue":"9","key":"zoi261011r59","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1093\/humrep\/dead130","article-title":"Age at menopause and all-cause and cause-specific dementia: a prospective analysis of the UK Biobank cohort.","volume":"38","author":"Hao","year":"2023","journal-title":"Hum Reprod"},{"issue":"3","key":"zoi261011r60","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1210\/er.2012-1055","article-title":"The role of estrogens in control of energy balance and glucose homeostasis.","volume":"34","author":"Mauvais-Jarvis","year":"2013","journal-title":"Endocr Rev"},{"issue":"2","key":"zoi261011r61","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0306-3623(02)00129-5","article-title":"Estrogen and vascular function.","volume":"38","author":"White","year":"2002","journal-title":"Vascul Pharmacol"},{"issue":"2","key":"zoi261011r62","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1124\/pr.107.08002","article-title":"Vascular actions of estrogens: functional implications.","volume":"60","author":"Miller","year":"2008","journal-title":"Pharmacol Rev"},{"key":"zoi261011r63","doi-asserted-by":"publisher","first-page":"e","DOI":"10.61622\/rbgo\/2025rbgo200","article-title":"Position statement on cardiometabolic health across the woman\u2019s life course\u20142025.","volume":"47","author":"de Oliveira","year":"2025","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"4","key":"zoi261011r64","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.ajog.2025.10.044","article-title":"Salpingectomy in individuals at high risk for tubo-ovarian cancer: consensus and precaution.","volume":"234","author":"Wilke","year":"2026","journal-title":"Am J Obstet Gynecol"},{"key":"zoi261011r65","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000006400","article-title":"Salpingectomy for the prevention of epithelial ovarian cancer.","author":"American College of Obstetricians & Gynecologists Committee on Clinical Consensus\u2014Gynecology","year":"2026","journal-title":"Obstet Gynecol"},{"key":"zoi261011r27","unstructured":"Lepine? LA, Hillis? SD, Marchbanks? PA, Koonin? LM, Morrow? B, Kieke? BA. Hysterectomy surveillance\u2014United States: 1980-1993. CDC MMWR Report. August 8, 1997. Accessed July 29, 2026. https:\/\/www.cdc.gov\/Mmwr\/preview\/mmwrhtml\/00048898.htm"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2854757\/armeni_2026_oi_261011_1790344424.70572.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:30:28Z","timestamp":1790955028000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2854757"}},"subtitle":["A Systematic Review and Meta-Analysis"],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2026.37545","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]}}}