{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:51:34Z","timestamp":1791820294729,"version":"4.3.4"},"reference-count":47,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Infantile colic is a disorder of gut-brain interaction whose cause is poorly understood.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To estimate associations of maternal diet quality and intakes of specific allergenic foods with infant eczema and colic.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Project Viva prospective cohort of 2128 mother-child pairs unselected for atopic risk with recruitment in early pregnancy in Eastern Massachusetts from April 1999 to November 2002, with follow-up to October 2003, and data analysis November 2025 to July 2026.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Prenatal diet via food frequency questionnaires in early pregnancy (median [IQR], 9.9 [8.8-11.3] weeks) and midpregnancy (median [IQR], 27.9 [26.7-28.8] weeks). The Mediterranean Diet Score (MDS) and Dietary Inflammatory Index (DII) were calculated and intake of commonly allergenic foods was determined.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Maternal report of colic symptoms and eczema diagnosis at median (IQR) of 6.3 (6.0-6.8) months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 1324 pairs with exposure and outcome data, mean (SD) maternal age was 32.6 (4.6) years, 667 (50.4%) were nulliparous, and 532 (40.2%) reported a history of atopy; 152 (11.5%) infants had eczema alone, 273 (20.6%) had colic alone, and 61 (4.6%) had both. In multinomial logistic regression models adjusted for maternal age, race, ethnicity, education, parity, smoking, and atopy, greater mean (SD) MDS (4.6 [2.0] points) was associated with lower odds of colic and eczema (odds ratio [OR], 0.85; 95% CI, 0.74-0.98 per 1 point), and mean (SD) DII (\u22122.7 [1.3]) was associated with higher odds (OR, 1.34; 95% CI, 1.12-1.61 per 1 point). Neither diet score was associated with eczema or colic alone. Seafood intake was associated with lower odds of colic and eczema combined (OR, 0.75; 95% CI, 0.58-0.97 per weekly serving). Nut intake was associated with higher risk for colic among those without eczema (eg, OR, 1.05; 95% CI, 1.00-1.09 per weekly serving of any nuts or peanuts), but not with colic and eczema combined (OR, 0.97; 95% CI, 0.88-1.07). Dairy or egg intakes were not associated with any outcomes. Associations of dietary scores and fish intake with colic were stronger among infants of atopic mothers.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of 1324 mother-child pairs, poorer maternal diet quality and lower seafood intake were associated with infantile colic with eczema or maternal atopic history.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2026.38472","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:30:29Z","timestamp":1791819029000},"page":"e2638472","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Prenatal Diet and Colic and Eczema Among Infants"],"prefix":"10.1001","volume":"9","author":[{"given":"Emily","family":"Oken","sequence":"first","affiliation":[{"name":"Division of Chronic Disease Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts"},{"name":"Department of Nutrition, Harvard T.H. 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