{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:45:09Z","timestamp":1791420309821,"version":"4.3.3"},"reference-count":49,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2018,11,1]]},"DOI":"10.1001\/jamaneurol.2018.2210","type":"journal-article","created":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T11:30:39Z","timestamp":1532259039000},"page":"1399","source":"Crossref","is-referenced-by-count":122,"title":["Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome"],"prefix":"10.1001","volume":"75","author":[{"given":"Eleonore","family":"Bayen","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9 Facult\u00e9 de M\u00e9decine, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re\u2013Assistance Publique H\u00f4pitaux de Paris, D\u00e9partement de R\u00e9\u00e9ducation Neurologique, Paris, France"},{"name":"Laboratoire d'Economie LEDa-LEGOS, Universit\u00e9 Paris\u2013Dauphine, PSL Research University, Paris, France"},{"name":"Global Brain Health Institute, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Possin","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute, University of California, San Francisco"},{"name":"Department of Neurology, Memory and Aging Center, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Cleret de Langavant","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute, University of California, San Francisco"},{"name":"Universit\u00e9 Paris Est Facult\u00e9 de M\u00e9decine, H\u00f4pital Henri Mondor\u2013Assistance Publique H\u00f4pitaux de Paris, Centre de r\u00e9f\u00e9rence Maladie de Huntington et service de neurologie, Cr\u00e9teil, France"},{"name":"D\u00e9partement d'Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL Research University et Inserm U955, Equipe E01 Neuropsychologie Interventionnelle, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute, University of California, San Francisco"},{"name":"Departments of Psychiatry, Neurology and Epidemiology and Biostatistics, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"noi180054r1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.jpeds.2013.06.013","article-title":"Current estimate of Down Syndrome population prevalence in the United States.","volume":"163","author":"Presson","year":"2013","journal-title":"J Pediatr"},{"issue":"1","key":"noi180054r2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/MRR.0000000000000147","article-title":"Ageing of people with Down\u2019s syndrome: a systematic literature review from 2000 to 2014.","volume":"39","author":"Covelli","year":"2016","journal-title":"Int J Rehabil Res"},{"issue":"4","key":"noi180054r3","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/ajmg.a.v161.4","article-title":"Changes in mortality and causes of death in the Swedish Down syndrome population.","volume":"161A","author":"Englund","year":"2013","journal-title":"Am J Med Genet A"},{"issue":"9311","key":"noi180054r4","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0140-6736(02)08092-3","article-title":"Mortality associated with Down\u2019s syndrome in the USA from 1983 to 1997: a population-based study.","volume":"359","author":"Yang","year":"2002","journal-title":"Lancet"},{"issue":"10","key":"noi180054r5","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S1474-4422(13)70228-X","article-title":"Strengthening connections between Down syndrome and AD.","volume":"12","year":"2013","journal-title":"Lancet Neurol"},{"issue":"3","key":"noi180054r6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.neurobiolaging.2004.08.005","article-title":"Alzheimer disease and Down syndrome: factors in pathogenesis.","volume":"26","author":"Lott","year":"2005","journal-title":"Neurobiol Aging"},{"issue":"6","key":"noi180054r7","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S1474-4422(16)00063-6","article-title":"Dementia in Down\u2019s syndrome.","volume":"15","author":"Ballard","year":"2016","journal-title":"Lancet Neurol"},{"issue":"11","key":"noi180054r10","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data.","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care"},{"key":"noi180054r11","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.5888\/pcd10.120239","article-title":"Defining and measuring chronic conditions: imperatives for research, policy, program, and practice.","volume":"10","author":"Goodman","year":"2013","journal-title":"Prev Chronic Dis"},{"key":"noi180054r12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12911-015-0155-5","article-title":"Methods for identifying 30 chronic conditions: application to administrative data.","volume":"15","author":"Tonelli","year":"2015","journal-title":"BMC Med Inform Decis Mak"},{"issue":"4","key":"noi180054r14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1177\/1077558711399580","article-title":"Review: health care utilization and costs of elderly persons with multiple chronic conditions.","volume":"68","author":"Lehnert","year":"2011","journal-title":"Med Care Res Rev"},{"issue":"1","key":"noi180054r15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1212\/WNL.58.1.62","article-title":"Alzheimer\u2019s disease and related dementias increase costs of comorbidities in managed Medicare.","volume":"58","author":"Hill","year":"2002","journal-title":"Neurology"},{"issue":"2","key":"noi180054r17","doi-asserted-by":"publisher","first-page":"mmrr.003.02.b02","DOI":"10.5600\/mmrr","article-title":"Medicare payments: how much do chronic conditions matter?","volume":"3","author":"Erdem","year":"2013","journal-title":"Medicare Medicaid Res Rev"},{"issue":"2","key":"noi180054r18","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/jgs.2004.52.issue-2","article-title":"The relationship between a dementia diagnosis, chronic illness, medicare expenditures, and hospital use.","volume":"52","author":"Bynum","year":"2004","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"noi180054r19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3233\/JAD-150228","article-title":"Nationwide inpatient prevalence, predictors, and outcomes of Alzheimer\u2019s disease among older adults in the United States, 2002-2012.","volume":"48","author":"Beydoun","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"noi180054r20","first-page":"Doc03","article-title":"Prevalence of chronic diseases among older patients in German general practices.","volume":"14","author":"Jacob","year":"2016","journal-title":"Ger Med Sci"},{"issue":"4","key":"noi180054r21","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1177\/1533317513488911","article-title":"The clinical and economic burden of newly diagnosed Alzheimer\u2019s disease in a medicare advantage population.","volume":"28","author":"Suehs","year":"2013","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"6","key":"noi180054r22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ejim.2015.05.003","article-title":"Clinical profile and main comorbidities of Spanish adults with Down syndrome.","volume":"26","author":"Real de Asua","year":"2015","journal-title":"Eur J Intern Med"},{"issue":"Pt. 6","key":"noi180054r23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/jir.2007.51.issue-6","article-title":"Fifteen-year follow-up of 92 hospitalized adults with Down\u2019s syndrome: incidence of cognitive decline, its relationship to age and neuropathology.","volume":"51","author":"Margallo-Lana","year":"2007","journal-title":"J Intellect Disabil Res"},{"issue":"8","key":"noi180054r24","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1001\/archneur.1989.00520440031017","article-title":"A prospective study of Alzheimer disease in Down syndrome.","volume":"46","author":"Lai","year":"1989","journal-title":"Arch Neurol"},{"issue":"4","key":"noi180054r25","first-page":"400","article-title":"Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome.","volume":"101","author":"Visser","year":"1997","journal-title":"Am J Ment Retard"},{"issue":"1","key":"noi180054r26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/jir.2014.58.issue-1","article-title":"A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome.","volume":"58","author":"McCarron","year":"2014","journal-title":"J Intellect Disabil Res"},{"issue":"12","key":"noi180054r27","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1002\/(ISSN)1099-1166","article-title":"Dementia in people with Down\u2019s syndrome.","volume":"16","author":"Tyrrell","year":"2001","journal-title":"Int J Geriatr Psychiatry"},{"issue":"pt 10","key":"noi180054r28","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/jir.2006.50.issue-10","article-title":"Dementia and mortality in persons with Down\u2019s syndrome.","volume":"50","author":"Coppus","year":"2006","journal-title":"J Intellect Disabil Res"},{"issue":"2","key":"noi180054r29","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1352\/0895-8017(1998)103<0130:DIAWDS>2.0.CO;2","article-title":"Dementia in adults with Down syndrome: diagnostic challenges.","volume":"103","author":"Burt","year":"1998","journal-title":"Am J Ment Retard"},{"key":"noi180054r30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0074-7750(08)00004-9","article-title":"Alzheimer\u2019s disease in adults with Down syndrome.","volume":"36","author":"Zigman","year":"2008","journal-title":"Int Rev Res Ment Retard"},{"issue":"pt 6","key":"noi180054r31","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1046\/j.1365-2788.2000.00305.x","article-title":"Sequence of cognitive decline in dementia in adults with Down\u2019s syndrome.","volume":"44","author":"Devenny","year":"2000","journal-title":"J Intellect Disabil Res"},{"issue":"14","key":"noi180054r32","doi-asserted-by":"publisher","first-page":"dn1","DOI":"10.1126\/sageke.2005.14.dn1","article-title":"Dementia of the Alzheimer\u2019s type and accelerated aging in Down syndrome.","volume":"2005","author":"Devenny","year":"2005","journal-title":"Sci Aging Knowledge Environ"},{"issue":"9968","key":"noi180054r33","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0140-6736(14)61596-8","article-title":"Multimorbidity: older adults need health care that can count past one.","volume":"385","author":"Banerjee","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"noi180054r34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/alzrt72","article-title":"What can we learn from study of Alzheimer\u2019s disease in patients with Down syndrome for early-onset Alzheimer\u2019s disease in the general population?","volume":"3","author":"Wallace","year":"2011","journal-title":"Alzheimers Res Ther"},{"issue":"534","key":"noi180054r35","first-page":"50","article-title":"Adults with Down\u2019s syndrome: the prevalence of complications and health care in the community.","volume":"57","author":"Henderson","year":"2007","journal-title":"Br J Gen Pract"},{"issue":"pt 7","key":"noi180054r36","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/jir.2005.49.issue-7","article-title":"Health co-morbidities in ageing persons with Down syndrome and Alzheimer\u2019s dementia.","volume":"49","author":"McCarron","year":"2005","journal-title":"J Intellect Disabil Res"},{"issue":"4","key":"noi180054r37","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1055\/s-00000071","article-title":"Young-onset dementia.","volume":"33","author":"Kuruppu","year":"2013","journal-title":"Semin Neurol"},{"issue":"5","key":"noi180054r38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/MED.0b013e32830eb84c","article-title":"Cognitive function in untreated hypothyroidism and hyperthyroidism.","volume":"15","author":"Samuels","year":"2008","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"1","key":"noi180054r39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/MED.0000000000000382","article-title":"Endocrine manifestations of Down syndrome.","volume":"25","author":"Whooten","year":"2018","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"noi180054r40","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.yebeh.2016.12.014","article-title":"The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy.","volume":"68","author":"Gholipour","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"2","key":"noi180054r41","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0950-3536(87)80004-5","article-title":"Iron deficiency in the elderly.","volume":"1","author":"Schultz","year":"1987","journal-title":"Baillieres Clin Haematol"},{"issue":"1","key":"noi180054r42","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13195-017-0322-2","article-title":"Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons.","volume":"9","author":"Jeong","year":"2017","journal-title":"Alzheimers Res Ther"},{"issue":"5","key":"noi180054r43","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.cmet.2015.08.016","article-title":"Metabolic and non-cognitive manifestations of Alzheimer\u2019s disease: the hypothalamus as both culprit and target of pathology.","volume":"22","author":"Ishii","year":"2015","journal-title":"Cell Metab"},{"issue":"4","key":"noi180054r44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1001\/jamaneurol.2015.4756","article-title":"Decline in weight and incident mild cognitive impairment: Mayo Clinic Study of Aging.","volume":"73","author":"Alhurani","year":"2016","journal-title":"JAMA Neurol"},{"issue":"1","key":"noi180054r45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ridd.2003.04.005","article-title":"Weight loss in adults with Down syndrome and with dementia in Alzheimer\u2019s disease.","volume":"25","author":"Prasher","year":"2004","journal-title":"Res Dev Disabil"},{"issue":"2","key":"noi180054r46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1352\/1934-9556-50.2.92","article-title":"Demographic characteristics, health conditions, and residential service use in adults with Down syndrome in 25 U.S. states.","volume":"50","author":"Stancliffe","year":"2012","journal-title":"Intellect Dev Disabil"},{"key":"noi180054r8","unstructured":"Centers for Medicare and Medicaid Services. What\u2019s Medicare? https:\/\/www.medicare.gov\/sign-up-change-plans\/decide-how-to-get-medicare\/whats-medicare\/what-is-medicare.html. Accessed February 12, 2018."},{"key":"noi180054r9","unstructured":"Centers for Medicare and Medicaid Services, Chronic Condition Data Warehouse. Technical guidance: calculating medicare population statistics. https:\/\/www.ccwdata.org\/web\/guest\/condition-categorieshttp:\/\/www.ccwdata.org\/index.htm. Accessed February 12, 2018."},{"key":"noi180054r13","unstructured":"Healthcare Cost and Utilization Project (H-CUP project). https:\/\/www.hcup-us.ahrq.gov\/2008. Accessed December 2017."},{"key":"noi180054r16","unstructured":"Agency for Healthcare Research and Quality (AHRQ). Multiple Chronic Conditions Chartbook: medical expenditure panel survey data. https:\/\/www.ahrq.gov\/sites\/default\/files\/wysiwyg\/professionals\/prevention-chronic-care\/decision\/mcc\/mccchartbook.pdf; Accessed February 12, 2018."},{"key":"noi180054r47","unstructured":"Social Security Administration. Disability planner: benefits for a disabled child. https:\/\/www.ssa.gov\/planners\/disability\/dqualify10.html. Published November 2017. Accessed February 12, 2018."},{"key":"noi180054r48","unstructured":"Disability and Down syndrome: filing for social security benefits. https:\/\/www.disabilitysecrets.com\/conditions-page-2-30.html. Published November 2017. Accessed February 12, 2018."},{"key":"noi180054r49","unstructured":"US Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development and the NIH Down Syndrome Working Group. Down Syndrome Directions National Institutes of Health Research Plan on Down Syndrome 2007, revised plan 2014. https:\/\/www.nichd.nih.gov\/publications\/pubs\/Document\/DSResearchPlan_2014.pdf. Accessed February 12, 2018."}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2694822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:18:19Z","timestamp":1571617099000},"score":1,"resource":{"primary":{"URL":"http:\/\/archneur.jamanetwork.com\/article.aspx?doi=10.1001\/jamaneurol.2018.2210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2018.2210","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}