{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:54:21Z","timestamp":1793894061316,"version":"4.8.0"},"reference-count":40,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2019,12,1]]},"DOI":"10.1001\/jamaneurol.2019.2399","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T11:00:55Z","timestamp":1565607655000},"page":"1474","source":"Crossref","is-referenced-by-count":540,"title":["Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo"],"prefix":"10.1001","volume":"76","author":[{"given":"Martina","family":"Absinta","sequence":"first","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Sati","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Masuzzo","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Nair","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Sethi","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Kolb","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Ohayon","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxia","family":"Wu","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene C. M.","family":"Cortese","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Reich","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"noi190062r1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis.","volume":"378","author":"Reich","year":"2018","journal-title":"N Engl J Med"},{"issue":"5","key":"noi190062r2","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ana.v78.5","article-title":"Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque.","volume":"78","author":"Frischer","year":"2015","journal-title":"Ann Neurol"},{"issue":"6","key":"noi190062r3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nrneurol.2016.59","article-title":"Advanced MRI and staging of multiple sclerosis lesions.","volume":"12","author":"Absinta","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"noi190062r4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00401-018-1818-y","article-title":"Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis.","volume":"135","author":"Luchetti","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"2","key":"noi190062r5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0165-5728(98)00031-9","article-title":"Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna.","volume":"86","author":"Lassmann","year":"1998","journal-title":"J Neuroimmunol"},{"issue":"1","key":"noi190062r6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions.","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol"},{"key":"noi190062r7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-pathol-011811-132443","article-title":"Pathology of demyelinating diseases.","volume":"7","author":"Popescu","year":"2012","journal-title":"Annu Rev Pathol"},{"issue":"7","key":"noi190062r8","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1172\/JCI86198","article-title":"Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions.","volume":"126","author":"Absinta","year":"2016","journal-title":"J Clin Invest"},{"issue":"1","key":"noi190062r9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00401-016-1636-z","article-title":"Slow expansion of multiple sclerosis iron rim lesions: pathology and 7T magnetic resonance imaging.","volume":"133","author":"Dal-Bianco","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"7","key":"noi190062r10","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1001\/archneurol.2010.148","article-title":"Imaging cortical lesions in multiple sclerosis with ultra-high-field magnetic resonance imaging.","volume":"67","author":"Pitt","year":"2010","journal-title":"Arch Neurol"},{"issue":"pt 12","key":"noi190062r11","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1093\/brain\/awr278","article-title":"Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.","volume":"134","author":"Bagnato","year":"2011","journal-title":"Brain"},{"issue":"1","key":"noi190062r12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1148\/radiol.11110601","article-title":"Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging.","volume":"262","author":"Yao","year":"2012","journal-title":"Radiology"},{"issue":"1","key":"noi190062r13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/jmri.23603","article-title":"Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study.","volume":"36","author":"Hagemeier","year":"2012","journal-title":"J Magn Reson Imaging"},{"issue":"6","key":"noi190062r14","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/ana.v64:6","article-title":"Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron.","volume":"64","author":"Hammond","year":"2008","journal-title":"Ann Neurol"},{"issue":"1","key":"noi190062r15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/1352458512447870","article-title":"A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis.","volume":"19","author":"Bian","year":"2013","journal-title":"Mult Scler"},{"issue":"2","key":"noi190062r16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1148\/radiol.12120863","article-title":"Multiple sclerosis: validation of MR imaging for quantification and detection of iron.","volume":"267","author":"Walsh","year":"2013","journal-title":"Radiology"},{"issue":"2","key":"noi190062r17","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/mrm.25420","article-title":"Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: interpreting positive susceptibility and the presence of iron.","volume":"74","author":"Wisnieff","year":"2015","journal-title":"Magn Reson Med"},{"issue":"8","key":"noi190062r18","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.3174\/ajnr.A4726","article-title":"Lesion heterogeneity on high-field susceptibility MRI is associated with multiple sclerosis severity.","volume":"37","author":"Harrison","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"issue":"7","key":"noi190062r19","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.3174\/ajnr.A5660","article-title":"Identification of chronic active multiple sclerosis lesions on 3T MRI.","volume":"39","author":"Absinta","year":"2018","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"noi190062r20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/brain\/awy296","article-title":"Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.","volume":"142","author":"Kaunzner","year":"2019","journal-title":"Brain"},{"issue":"2","key":"noi190062r21","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria.","volume":"69","author":"Polman","year":"2011","journal-title":"Ann Neurol"},{"issue":"11","key":"noi190062r22","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"issue":"7","key":"noi190062r23","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1212\/01.WNL.0000156155.19270.F8","article-title":"Multiple sclerosis severity score: using disability and disease duration to rate disease severity.","volume":"64","author":"Roxburgh","year":"2005","journal-title":"Neurology"},{"issue":"11","key":"noi190062r24","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1177\/1352458514525868","article-title":"Rapid, high-resolution, whole-brain, susceptibility-based MRI of multiple sclerosis.","volume":"20","author":"Sati","year":"2014","journal-title":"Mult Scler"},{"issue":"1","key":"noi190062r25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1212\/WNL.0000000000001587","article-title":"Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis.","volume":"85","author":"Absinta","year":"2015","journal-title":"Neurology"},{"issue":"2","key":"noi190062r26","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.neuroimage.2009.09.005","article-title":"A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions.","volume":"49","author":"Shiee","year":"2010","journal-title":"Neuroimage"},{"issue":"8","key":"noi190062r27","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1097\/NEN.0000000000000096","article-title":"Postmortem magnetic resonance imaging to guide the pathologic cut: individualized, 3-dimensionally printed cutting boxes for fixed brains.","volume":"73","author":"Absinta","year":"2014","journal-title":"J Neuropathol Exp Neurol"},{"issue":"13","key":"noi190062r28","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1177\/1352458515569098","article-title":"Sample-size calculations for short-term proof-of-concept studies of tissue protection and repair in multiple sclerosis lesions via conventional clinical imaging.","volume":"21","author":"Reich","year":"2015","journal-title":"Mult Scler"},{"issue":"3","key":"noi190062r29","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1177\/1352458516655403","article-title":"Slowly eroding lesions in multiple sclerosis.","volume":"23","author":"Sethi","year":"2017","journal-title":"Mult Scler"},{"issue":"5","key":"noi190062r30","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/jon.2018.28.issue-5","article-title":"Atrophied brain lesion volume: a new imaging biomarker in multiple sclerosis.","volume":"28","author":"Dwyer","year":"2018","journal-title":"J Neuroimaging"},{"issue":"5","key":"noi190062r31","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1002\/ana.v74.5","article-title":"Seven-tesla phase imaging of acute multiple sclerosis lesions: a new window into the inflammatory process.","volume":"74","author":"Absinta","year":"2013","journal-title":"Ann Neurol"},{"issue":"6","key":"noi190062r32","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41593-018-0145-x","article-title":"Microglial immune checkpoint mechanisms.","volume":"21","author":"Deczkowska","year":"2018","journal-title":"Nat Neurosci"},{"issue":"7","key":"noi190062r33","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/brain\/awx113","article-title":"Loss of \u2018homeostatic\u2019 microglia and patterns of their activation in active multiple sclerosis.","volume":"140","author":"Zrzavy","year":"2017","journal-title":"Brain"},{"issue":"9","key":"noi190062r34","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis.","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"noi190062r35","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1001\/archneurol.2008.541","article-title":"Modification of multiple sclerosis phenotypes by African Ancestry at HLA.","volume":"66","author":"Cree","year":"2009","journal-title":"Arch Neurol"},{"issue":"3","key":"noi190062r36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1212\/WNL.0b013e3181e8e72a","article-title":"Rapid disease course in African Americans with multiple sclerosis.","volume":"75","author":"Kister","year":"2010","journal-title":"Neurology"},{"issue":"pt 1","key":"noi190062r37","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1093\/brain\/awn301","article-title":"Genotype-phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.","volume":"132","author":"Okuda","year":"2009","journal-title":"Brain"},{"issue":"3","key":"noi190062r38","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/nan.2015.41.issue-3","article-title":"The influence of HLA-DRB1*15 on motor cortical pathology in multiple sclerosis.","volume":"41","author":"Yates","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"noi190062r39","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S1474-4422(14)70294-7","article-title":"MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis.","volume":"14","author":"Gass","year":"2015","journal-title":"Lancet Neurol"},{"issue":"3","key":"noi190062r40","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nrn3900","article-title":"Exploring the origins of grey matter damage in multiple sclerosis.","volume":"16","author":"Calabrese","year":"2015","journal-title":"Nat Rev Neurosci"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2747565\/jamaneurology_absinta_2019_oi_190062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T18:56:14Z","timestamp":1581101774000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2747565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,1]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2019.2399","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,1]]}}}