{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:10:10Z","timestamp":1788318610718,"version":"build-2803163510"},"reference-count":36,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2021,2,1]]},"DOI":"10.1001\/jamaneurol.2020.3921","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T11:48:09Z","timestamp":1603108089000},"page":"217","source":"Crossref","is-referenced-by-count":58,"title":["Association of Initial \u03b2-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment"],"prefix":"10.1001","volume":"78","author":[{"given":"David S.","family":"Knopman","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Lundt","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry M.","family":"Therneau","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina M.","family":"Albertson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Gunter","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Senjem","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Machulda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthi","family":"Vemuri","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejal","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"6","key":"noi200076r1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1093\/brain\/awz090","article-title":"A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer\u2019s disease dementia.","volume":"142","author":"Pontecorvo","year":"2019","journal-title":"Brain"},{"issue":"1","key":"noi200076r2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease.","volume":"79","author":"Johnson","year":"2015","journal-title":"Ann Neurol"},{"issue":"1","key":"noi200076r3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/brain\/awx320","article-title":"Widespread brain tau and its association with ageing, Braak stage and Alzheimer\u2019s dementia.","volume":"141","author":"Lowe","year":"2018","journal-title":"Brain"},{"issue":"9","key":"noi200076r4","doi-asserted-by":"publisher","first-page":"e859","DOI":"10.1212\/WNL.0000000000006075","article-title":"Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease.","volume":"91","author":"Aschenbrenner","year":"2018","journal-title":"Neurology"},{"issue":"5","key":"noi200076r5","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1093\/brain\/awy059","article-title":"Longitudinal tau PET in ageing and Alzheimer\u2019s disease.","volume":"141","author":"Jack","year":"2018","journal-title":"Brain"},{"issue":"8","key":"noi200076r6","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of amyloid and tau with cognition in preclinical Alzheimer disease: a longitudinal study.","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol"},{"issue":"2","key":"noi200076r7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/ana.v85.2","article-title":"Longitudinal tau accumulation and atrophy in aging and alzheimer disease.","volume":"85","author":"Harrison","year":"2019","journal-title":"Ann Neurol"},{"issue":"19","key":"noi200076r8","doi-asserted-by":"publisher","first-page":"4482","DOI":"10.1523\/JNEUROSCI.0485-18.2018","article-title":"Subthreshold amyloid predicts tau deposition in aging.","volume":"38","author":"Leal","year":"2018","journal-title":"J Neurosci"},{"issue":"1","key":"noi200076r9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1159\/000115751","article-title":"The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics.","volume":"30","author":"Roberts","year":"2008","journal-title":"Neuroepidemiology"},{"issue":"4","key":"noi200076r10","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1212\/WNL.0000000000000055","article-title":"Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal.","volume":"82","author":"Roberts","year":"2014","journal-title":"Neurology"},{"issue":"10","key":"noi200076r11","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1093\/brain\/awz268","article-title":"The bivariate distribution of amyloid-\u00df and tau: relationship with established neurocognitive clinical syndromes.","volume":"142","author":"Jack","year":"2019","journal-title":"Brain"},{"issue":"1","key":"noi200076r12","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1212\/WNL.0000000000007728","article-title":"Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults.","volume":"93","author":"Lowe","year":"2019","journal-title":"Neurology"},{"issue":"4","key":"noi200076r13","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1093\/brain\/awz025","article-title":"Entorhinal cortex tau, amyloid-\u00df, cortical thickness and memory performance in non-demented subjects.","volume":"142","author":"Knopman","year":"2019","journal-title":"Brain"},{"key":"noi200076r14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.dadm.2018.01.005","article-title":"Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants.","volume":"10","author":"Lowe","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"issue":"3","key":"noi200076r15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease.","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement"},{"key":"noi200076r16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.dadm.2016.12.010","article-title":"Tau-PET uptake: regional variation in average SUVR and impact of amyloid deposition.","volume":"6","author":"Vemuri","year":"2016","journal-title":"Alzheimers Dement (Amst)"},{"issue":"pt 3","key":"noi200076r17","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer\u2019s disease and amnestic mild cognitive impairment.","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"issue":"2","key":"noi200076r18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.25395","article-title":"The impact of amyloid-beta and tau on prospective cognitive decline in older individuals.","volume":"85","author":"Sperling","year":"2019","journal-title":"Ann Neurol"},{"issue":"12","key":"noi200076r19","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD.","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"Pt 5","key":"noi200076r20","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1093\/brain\/awv050","article-title":"Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer\u2019s disease spectrum.","volume":"138","author":"Murray","year":"2015","journal-title":"Brain"},{"issue":"7","key":"noi200076r21","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.jalz.2019.03.016","article-title":"Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease.","volume":"15","author":"Lowe","year":"2019","journal-title":"Alzheimers Dement"},{"key":"noi200076r22","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.neuroimage.2018.08.044","article-title":"Implementing the centiloid transformation for 11C-PiB and \u00df-amyloid 18F-PET tracers using CapAIBL.","volume":"183","author":"Bourgeat","year":"2018","journal-title":"Neuroimage"},{"issue":"12","key":"noi200076r23","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.jalz.2018.06.1353","article-title":"Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale.","volume":"14","author":"Navitsky","year":"2018","journal-title":"Alzheimers Dement"},{"key":"noi200076r24","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.dadm.2018.12.008","article-title":"Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.","volume":"11","author":"Su","year":"2019","journal-title":"Alzheimers Dement (Amst)"},{"issue":"2","key":"noi200076r25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jalz.2018.09.001","article-title":"Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer\u2019s disease neuropathology.","volume":"15","author":"La Joie","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"10","key":"noi200076r26","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1212\/WNL.0b013e3182840bbe","article-title":"Brain \u00df-amyloid load approaches a plateau.","volume":"80","author":"Jack","year":"2013","journal-title":"Neurology"},{"issue":"4","key":"noi200076r27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u00df deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: a prospective cohort study.","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"noi200076r28","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.jalz.2018.06.1806","article-title":"Accelerated failure time as a model for amyloid and tau accumulation.","volume":"14","author":"Therneau","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"Pt 5","key":"noi200076r29","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/brain\/aww023","article-title":"Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages.","volume":"139","author":"Schwarz","year":"2016","journal-title":"Brain"},{"issue":"5","key":"noi200076r30","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain.","volume":"89","author":"Sch\u00f6ll","year":"2016","journal-title":"Neuron"},{"issue":"338","key":"noi200076r31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2362","article-title":"Tau and A\u00df imaging, CSF measures, and cognition in Alzheimer\u2019s disease.","volume":"8","author":"Brier","year":"2016","journal-title":"Sci Transl Med"},{"issue":"2","key":"noi200076r32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/ana.v80.2","article-title":"In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum.","volume":"80","author":"Cho","year":"2016","journal-title":"Ann Neurol"},{"issue":"Pt 5","key":"noi200076r33","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer\u2019s disease.","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"issue":"3","key":"noi200076r34","first-page":"748","article-title":"Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition.","volume":"140","author":"Pontecorvo","year":"2017","journal-title":"Brain"},{"issue":"4","key":"noi200076r35","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes.","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"issue":"6","key":"noi200076r36","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1212\/WNL.52.6.1158","article-title":"The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer\u2019s disease.","volume":"52","author":"Delacourte","year":"1999","journal-title":"Neurology"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2771830\/jamaneurology_knopman_2020_oi_200076_1612851417.8503.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:04:00Z","timestamp":1696896240000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2771830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2020.3921","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}