{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:37:42Z","timestamp":1792132662202,"version":"4.4.0"},"reference-count":18,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2021,3,1]]},"DOI":"10.1001\/jamaneurol.2020.4725","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:34:40Z","timestamp":1607952880000},"page":"312","source":"Crossref","is-referenced-by-count":140,"title":["Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease"],"prefix":"10.1001","volume":"78","author":[{"given":"Tanya","family":"Simuni","sequence":"first","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fiske","sequence":"additional","affiliation":[{"name":"Research Programs, Michael J. Fox Foundation for Parkinson\u2019s Research, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Klingner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Caspell-Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David-Erick","family":"Lafontant","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Matthews","sequence":"additional","affiliation":[{"name":"The Cure Parkinson\u2019s Trust, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Wyse","sequence":"additional","affiliation":[{"name":"Research and Development, The Cure Parkinson\u2019s Trust, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Brundin","sequence":"additional","affiliation":[{"name":"Van Andel Institute, Center for Neurodegenerative Science, Grand Rapids, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Simon","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwarzschild","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weiner","sequence":"additional","affiliation":[{"name":"Consultant, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Venuto","sequence":"additional","affiliation":[{"name":"CHET CTCC, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted M.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Baker","sequence":"additional","affiliation":[{"name":"CHET CTCC, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Kostrzebski","sequence":"additional","affiliation":[{"name":"CHET CTCC, University of Rochester, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Rafaloff","sequence":"additional","affiliation":[{"name":"Steven\u2019s Institute of Technology, Marlboro, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Parkinson Study Group NILO-PD Investigators and Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Adams","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Augustine","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Baker","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Brocht","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Casaceli","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Eaton","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Henderson","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole","family":"McMullen","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phounsavath","family":"Muneath","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Trusso","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlinda","family":"Field","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Brahmachari","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Carman","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Kamp","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bolger","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Wegel","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Reynolds","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Levy","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Servi","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Chou","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela S","family":"Stovall","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Pal","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Keith","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Chung","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohi","family":"Shahed","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hunter","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binit","family":"Shah","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Sullivan","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Y.","family":"Hung","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Bwala","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Spindler","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Oliver","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hauser","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rocha","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Molho","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Evans","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Shill","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Ismail","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natividad","family":"Stover","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Cromer","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Blair","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kishchenko","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Swan","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ramirez","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Frank","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Burrows","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Duker","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gruenwald","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Blindauer","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Wheeler","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Seeberger","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Simpson","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton L.","family":"Scott","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gauger","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Pitchford","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mule","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Ramirez-Zamora","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek B.","family":"Ridgeway","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Slevin","family":"Slevin","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee Wagner","family":"Wagner","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Hinson","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonna","family":"Jenkins","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Goudreau","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doozie","family":"Russell","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Mari","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilliana","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Aldred","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Bixby","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"LeDoux","sequence":"additional","affiliation":[{"name":"for the Parkinson Study Group NILO-PD Investigators and Collaborators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"6","key":"noi200091r1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease.","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol"},{"issue":"5","key":"noi200091r2","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/mds.v33.5","article-title":"Disease modification in Parkinson\u2019s disease: current approaches, challenges, and future considerations.","volume":"33","author":"Lang","year":"2018","journal-title":"Mov Disord"},{"key":"noi200091r3","doi-asserted-by":"publisher","first-page":"4874","DOI":"10.1038\/srep04874","article-title":"The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson\u2019s disease.","volume":"4","author":"Karuppagounder","year":"2014","journal-title":"Sci Rep"},{"issue":"16","key":"noi200091r4","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1093\/hmg\/ddt192","article-title":"Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of a-synuclein in Parkinson\u2019s disease models.","volume":"22","author":"Hebron","year":"2013","journal-title":"Hum Mol Genet"},{"key":"noi200091r5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4172\/2155-9899","article-title":"Tyrosine kinase inhibition regulates early systemic immune changes and modulates the neuroimmune response in a-synucleinopathy.","volume":"5","author":"Hebron","year":"2014","journal-title":"J Clin Cell Immunol"},{"issue":"4","key":"noi200091r6","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1212\/WNL.48.4.1094","article-title":"REM sleep behavior disorders in multiple system atrophy.","volume":"48","author":"Plazzi","year":"1997","journal-title":"Neurology"},{"issue":"3","key":"noi200091r7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3233\/JPD-160867","article-title":"Nilotinib effects in Parkinson\u2019s disease and dementia with Lewy bodies.","volume":"6","author":"Pagan","year":"2016","journal-title":"J Parkinsons Dis"},{"issue":"3","key":"noi200091r8","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1001\/jamaneurol.2019.4200","article-title":"Nilotinib effects on safety, tolerability, and potential biomarkers in Parkinson disease: a phase 2 randomized clinical trial.","volume":"77","author":"Pagan","year":"2020","journal-title":"JAMA Neurol"},{"issue":"6","key":"noi200091r9","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1212\/WNL.42.6.1142","article-title":"What features improve the accuracy of clinical diagnosis in Parkinson\u2019s disease: a clinicopathologic study.","volume":"42","author":"Hughes","year":"1992","journal-title":"Neurology"},{"issue":"5","key":"noi200091r10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: onset, progression and mortality.","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"issue":"15","key":"noi200091r11","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord"},{"issue":"2","key":"noi200091r12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/clpt.2009.208","article-title":"Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib.","volume":"87","author":"Tanaka","year":"2010","journal-title":"Clin Pharmacol Ther"},{"issue":"12","key":"noi200091r13","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1038\/sj.bjc.6603170","article-title":"AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.","volume":"94","author":"Weisberg","year":"2006","journal-title":"Br J Cancer"},{"issue":"10","key":"noi200091r14","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/mds.25122","article-title":"Calibration of unified Parkinson\u2019s disease rating scale scores to Movement Disorder Society-unified Parkinson\u2019s disease rating scale scores.","volume":"27","author":"Goetz","year":"2012","journal-title":"Mov Disord"},{"issue":"2","key":"noi200091r15","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.470","article-title":"Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson\u2019s disease.","volume":"7","author":"Pagan","year":"2019","journal-title":"Pharmacol Res Perspect"},{"issue":"1","key":"noi200091r16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3233\/JPD-160975","article-title":"Could MAO-B inhibitor withdrawal rather than nilotinib benefit explain the dopamine metabolite increase in Parkinsonian study subjects?","volume":"7","author":"Schwarzschild","year":"2017","journal-title":"J Parkinsons Dis"},{"issue":"3","key":"noi200091r17","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1001\/jamaneurol.2019.3983","article-title":"The narrowing path for nilotinib and other potential disease-modifying therapies for Parkinson disease.","volume":"77","author":"Espay","year":"2020","journal-title":"JAMA Neurol"},{"issue":"4","key":"noi200091r18","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3233\/JPD-171191","article-title":"c-Abl and Parkinson\u2019s disease: mechanisms and therapeutic potential.","volume":"7","author":"Brahmachari","year":"2017","journal-title":"J Parkinsons Dis"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2773698\/jamaneurology_simuni_2020_oi_200091_1614894403.37383.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T11:01:12Z","timestamp":1615460472000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2773698"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2020.4725","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}