{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:44:49Z","timestamp":1791999889622,"version":"4.4.0"},"reference-count":42,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2022,2,1]]},"DOI":"10.1001\/jamaneurol.2021.4514","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T11:02:13Z","timestamp":1638788533000},"page":"141","source":"Crossref","is-referenced-by-count":58,"title":["Comparison of Ticagrelor vs Clopidogrel in Addition to Aspirin in Patients With Minor Ischemic Stroke and Transient Ischemic Attack"],"prefix":"10.1001","volume":"79","author":[{"given":"Ronda","family":"Lun","sequence":"first","affiliation":[{"name":"University of Ottawa School of Epidemiology and Public Health, Ottawa, Ontario, Canada"},{"name":"Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"University of Ottawa School of Epidemiology and Public Health, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Zitikyte","sequence":"additional","affiliation":[{"name":"University of Ottawa School of Epidemiology and Public Health, Ottawa, Ontario, Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Carole","family":"Roy","sequence":"additional","affiliation":[{"name":"University of Ottawa School of Epidemiology and Public Health, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hutton","sequence":"additional","affiliation":[{"name":"University of Ottawa School of Epidemiology and Public Health, Ottawa, Ontario, Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar","family":"Dowlatshahi","sequence":"additional","affiliation":[{"name":"University of Ottawa School of Epidemiology and Public Health, Ottawa, Ontario, Canada"},{"name":"Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"key":"noi210078r1","doi-asserted-by":"crossref","first-page":"k5108","DOI":"10.1136\/bmj.k5108","article-title":"Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis.","volume":"363","author":"Hao","year":"2018","journal-title":"BMJ"},{"issue":"1","key":"noi210078r2","first-page":"2","article-title":"Risk factors of transient ischemic attack: an overview.","volume":"7","author":"Khare","year":"2016","journal-title":"J Midlife Health"},{"issue":"23","key":"noi210078r3","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1056\/NEJMoa1802712","article-title":"Five-year risk of stroke after TIA or minor ischemic stroke.","volume":"378","author":"Amarenco","year":"2018","journal-title":"N Engl J Med"},{"issue":"3","key":"noi210078r4","article-title":"Prediction factors of recurrent ischemic events in one year after minor stroke.","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"noi210078r5","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1161\/STROKEAHA.107.513234","article-title":"Recurrent events in transient ischemic attack and minor stroke: what events are happening and to which patients?","volume":"39","author":"Coutts","year":"2008","journal-title":"Stroke"},{"key":"noi210078r6","doi-asserted-by":"crossref","first-page":"l895","DOI":"10.1136\/bmj.l895","article-title":"Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack.","volume":"364","author":"Wang","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"noi210078r7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1215340","article-title":"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"noi210078r8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1056\/NEJMoa1800410","article-title":"Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA.","volume":"379","author":"Johnston","year":"2018","journal-title":"N Engl J Med"},{"issue":"12","key":"noi210078r9","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association.","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"issue":"4","key":"noi210078r10","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1177\/1747493017743062","article-title":"Canadian stroke best practice recommendations: secondary prevention of stroke, sixth edition practice guidelines, update 2017.","volume":"13","author":"Wein","year":"2018","journal-title":"Int J Stroke"},{"issue":"3","key":"noi210078r11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1056\/NEJMoa1916870","article-title":"Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA.","volume":"383","author":"Johnston","year":"2020","journal-title":"N Engl J Med"},{"issue":"2","key":"noi210078r12","doi-asserted-by":"publisher","first-page":"CLXXXVII","DOI":"10.1177\/23969873211000877","article-title":"European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA.","volume":"6","author":"Dawson","year":"2021","journal-title":"Eur Stroke J"},{"issue":"4","key":"noi210078r13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0250553","article-title":"Ticagrelor vs clopidogrel in addition to aspirin in minor ischemic stroke\/transient ischemic attack\u2014protocol for a systematic review and network meta-analysis.","volume":"16","author":"Zitikyte","year":"2021","journal-title":"PLoS One"},{"issue":"11","key":"noi210078r14","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations.","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann Intern Med"},{"issue":"n71","key":"noi210078r15","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"noi210078r16","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials.","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"noi210078r18","doi-asserted-by":"publisher","first-page":"943","DOI":"10.18549\/PharmPract.2017.01.943","article-title":"Network meta-analysis: a technique to gather evidence from direct and indirect comparisons.","volume":"15","author":"Tonin","year":"2017","journal-title":"Pharm Pract (Granada)"},{"issue":"2","key":"noi210078r19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial.","volume":"64","author":"Salanti","year":"2011","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"noi210078r20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s12874-019-0829-2","article-title":"BUGSnet: an R package to facilitate the conduct and reporting of Bayesian network Meta-analyses.","volume":"19","author":"B\u00e9liveau","year":"2019","journal-title":"BMC Med Res Methodol"},{"issue":"2-4","key":"noi210078r22","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.prevetmed.2007.01.003","article-title":"Assessing the convergence of Markov Chain Monte Carlo methods: an example from evaluation of diagnostic tests in absence of a gold standard.","volume":"79","author":"Toft","year":"2007","journal-title":"Prev Vet Med"},{"issue":"4","key":"noi210078r23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/10618600.1998.10474787","article-title":"General methods for monitoring convergence of iterative simulations.","volume":"7","author":"Brooks","year":"1998","journal-title":"J Comput Graph Stat"},{"issue":"8","key":"noi210078r24","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1161\/CIRCULATIONAHA.119.040713","article-title":"Time course for benefit and risk of clopidogrel and aspirin after acute transient ischemic attack and minor ischemic stroke.","volume":"140","author":"Johnston","year":"2019","journal-title":"Circulation"},{"issue":"7","key":"noi210078r25","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1001\/jamaneurol.2019.0932","article-title":"Risk for major hemorrhages in patients receiving clopidogrel and aspirin compared with aspirin alone after transient ischemic attack or minor ischemic stroke: a secondary analysis of the POINT randomized clinical trial.","volume":"76","author":"Tillman","year":"2019","journal-title":"JAMA Neurol"},{"issue":"7","key":"noi210078r26","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1212\/WNL.0000000000001844","article-title":"Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy.","volume":"85","author":"Wang","year":"2015","journal-title":"Neurology"},{"issue":"3","key":"noi210078r27","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1161\/STROKEAHA.119.027465","article-title":"Disability after minor stroke and transient ischemic attack in the POINT trial.","volume":"51","author":"Cucchiara","year":"2020","journal-title":"Stroke"},{"key":"noi210078r28","doi-asserted-by":"crossref","first-page":"l2211","DOI":"10.1136\/bmj.l2211","article-title":"Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint, randomised controlled phase II trial.","volume":"365","author":"Wang","year":"2019","journal-title":"BMJ"},{"issue":"11","key":"noi210078r29","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S1474-4422(07)70250-8","article-title":"Fast Assessment of Stroke and Transient Ischaemic Attack to Prevent Early Recurrence (FASTER): a randomised controlled pilot trial.","volume":"6","author":"Kennedy","year":"2007","journal-title":"Lancet Neurol"},{"issue":"9558","key":"noi210078r30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0140-6736(07)60150-0","article-title":"Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack.","volume":"369","author":"Johnston","year":"2007","journal-title":"Lancet"},{"issue":"11","key":"noi210078r31","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1001\/archinte.159.11.1248","article-title":"A metaregression analysis of the dose-response effect of aspirin on stroke.","volume":"159","author":"Johnson","year":"1999","journal-title":"Arch Intern Med"},{"key":"noi210078r32","article-title":"Bleeding complications with clopidogrel or ticagrelor in ST-elevation myocardial infarction patients\u2014a real life cohort study of two treatment strategies.","volume":"27","author":"Alfredsson","year":"2020","journal-title":"Int J Cardiol Heart Vasc"},{"issue":"43","key":"noi210078r33","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012978","article-title":"Choosing between ticagrelor and clopidogrel following percutaneous coronary intervention: a systematic review and meta-analysis (2007-2017).","volume":"97","author":"Guan","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"noi210078r34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3109\/00207454.2012.744308","article-title":"Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention.","volume":"123","author":"Hasan","year":"2013","journal-title":"Int J Neurosci"},{"issue":"12","key":"noi210078r35","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.jacc.2010.04.047","article-title":"Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.","volume":"56","author":"Bonello","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"noi210078r36","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1001\/jamaneurol.2019.2531","article-title":"Outcomes associated with clopidogrel-aspirin use in minor stroke or transient ischemic attack: a pooled analysis of Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) and Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trials.","volume":"76","author":"Pan","year":"2019","journal-title":"JAMA Neurol"},{"issue":"2","key":"noi210078r37","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1586\/ern.10.203","article-title":"Antiplatelet resistance in stroke.","volume":"11","author":"Top\u00e7uoglu","year":"2011","journal-title":"Expert Rev Neurother"},{"issue":"4","key":"noi210078r38","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/ATVBAHA.118.311963","article-title":"Clinical utility of CYP2C19 genotyping to guide antiplatelet therapy in patients with an acute coronary syndrome or undergoing percutaneous coronary intervention.","volume":"39","author":"Klein","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"noi210078r39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1001\/jama.2016.8662","article-title":"Association between CYP2C19 loss-of-function allele status and efficacy of clopidogrel for risk reduction among patients with minor stroke or transient ischemic attack.","volume":"316","author":"Wang","year":"2016","journal-title":"JAMA"},{"issue":"2","key":"noi210078r41","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1136\/svn-2020-000791","article-title":"Clopidogrel With Aspirin in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial.","volume":"6","author":"Wang","year":"2021","journal-title":"Stroke Vasc Neurol"},{"issue":"6","key":"noi210078r42","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1161\/STROKEAHA.120.033033","article-title":"Dual antiplatelet therapy versus aspirin in patients with stroke or transient ischemic attack: meta-analysis of randomized controlled trials.","volume":"52","author":"Bhatia","year":"2021","journal-title":"Stroke"},{"key":"noi210078r17","doi-asserted-by":"crossref","unstructured":"Harrer? M, Cuijpers? P, Furukawa? TA, Ebert? DD. Doing meta-analysis in R. Accessed April 29, 2021. https:\/\/bookdown.org\/MathiasHarrer\/Doing_Meta_Analysis_in_R\/","DOI":"10.1201\/9781003107347-3"},{"key":"noi210078r21","unstructured":"Dias? S, Welton? NJ, Sutton? AJ, Caldwell? DM, Lu? G, Ades? AE. NICE DSU technical support document 4: inconsistency in networks of evidence based on randomised controlled trials. Accessed March 10, 2021. https:\/\/research-information.bris.ac.uk\/en\/publications\/nice-dsu-technical-support-document-4-inconsistency-in-networks-o"},{"key":"noi210078r40","unstructured":"Clopidogrel with aspirin in high-risk patients with acute non-disabling cerebrovascular events II (CHANCE-2). ClinicalTrials.gov identifier: NCT04078737. Updated August 3, 2021. Accessed August 3, 2021. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04078737"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2786578\/jamaneurology_lun_2021_oi_210078_1644604380.20109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T17:47:05Z","timestamp":1726249625000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2786578"}},"subtitle":["A Network Meta-analysis"],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2021.4514","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}