{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:14:43Z","timestamp":1793459683606,"version":"4.5.0"},"reference-count":27,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec id=\"ab-noi220046-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>National Institute on Aging\u2013Alzheimer\u2019s Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi220046-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi220046-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This longitudinal cohort study used data from 4 independent population-based cohorts (PREVENT-AD, HABS, AIBL, and Knight ADRC) collected between 2003 and 2021. Participants were older adults without cognitive impairment with 1 year or more of clinical observation after amyloid \u03b2 and tau positron emission tomography (PET). Median clinical follow-up after PET ranged from 1.94 to 3.66 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi220046-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Based on binary assessment of global amyloid burden (A) and a composite temporal region of tau PET uptake (T), participants were stratified into 4 groups (A+T+, A+T\u2212, A\u2212T+, A\u2212T\u2212). Presence (+) or absence (\u2212) of neurodegeneration (N) was assessed using temporal cortical thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi220046-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Each cohort was analyzed separately. Primary outcome was clinical progression to mild cognitive impairment (MCI), identified by a Clinical Dementia Rating score of 0.5 or greater in Knight ADRC and by consensus committee review in the other cohorts. Clinical raters were blind to imaging, genetic, and fluid biomarker data. A secondary outcome was cognitive decline, based on a slope greater than 1.5 SD below the mean of an independent subsample of individuals without cognitive impairment. Outcomes were compared across the biomarker groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi220046-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 580 participants (PREVENT-AD, 128; HABS, 153; AIBL, 48; Knight ADRC, 251), mean (SD) age ranged from 67 (5) to 76 (6) years across cohorts, with between 55% (137\/251) and 74% (95\/128) female participants. Across cohorts, 33% to 83% of A+T+ participants progressed to MCI during follow-up (mean progression time, 2-2.72 years), compared with less than 20% of participants in other biomarker groups. Progression further increased to 43% to 100% when restricted to A+T+(N+) individuals. Cox proportional hazard ratios for progression to MCI in the A+T+ group vs other biomarker groups were all 5 or greater. Many A+T+ nonprogressors also showed longitudinal cognitive decline, while cognitive trajectories in other groups remained predominantly stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi220046-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>The clinical prognostic value of NIA-AA research criteria was confirmed in 4 independent cohorts, with most A+T+(N+) older individuals without cognitive impairment developing AD symptoms within 2 to 3 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamaneurol.2022.2379","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T14:30:29Z","timestamp":1659191429000},"page":"975","source":"Crossref","is-referenced-by-count":123,"title":["Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment"],"prefix":"10.1001","volume":"79","author":[{"given":"Cherie","family":"Strikwerda-Brown","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana A.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gonneaud","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"},{"name":"Inserm, Inserm UMR-S U1237, Universit\u00e9 de Caen-Normandie, GIP Cyceron, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"St-Onge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa Pichet","family":"Binette","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"},{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazal","family":"Ozlen","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Provost","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Soucy","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel F.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston"},{"name":"Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L. S.","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston"},{"name":"Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston"},{"name":"Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C. S.","family":"Breitner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"},{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PREVENT-AD, HABS, and AIBL Research Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tam","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Labonte","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Pichet Binette","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Anne-Marie","family":"Faubert","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Mathieu","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Madjar","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Edouard","family":"Carrier","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dansereau","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kazazian","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Lepage","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Picard","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Maillet","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Michaud","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Couture","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Dea","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cuello","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Barkun","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Evans","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Courcot","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tardif","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Debacker","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Jack","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fontaine","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Knopman","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Multhaup","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Near","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie-Marie","family":"Leoutsakos","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Robert","family":"Maltais","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Brandt","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Pruessner","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Morris","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Breitner","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laksanun","family":"Cheewakriengkrai","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa-Marie","family":"M\u00c3\u00bcnter","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Collins","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallar","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sager","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Dauar-Tedeschi","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Rajah","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Aisen","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paule-Joanne","family":"Toussaint","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bellec","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Kostopoulos","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Etienne","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tariot","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Orban","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa","family":"Sperling","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Hoge","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Thomas","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Craft","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Montine","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasavan","family":"Nair","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Bohbot","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Venugopalan","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Fonov","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Ituria-Medina","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaven","family":"Khachaturian","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Teigner","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Anthal","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Yu","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Ferdinand","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Pogossova","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginette","family":"Mayrand","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guerda","family":"Duclair","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guylaine","family":"Gagne","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Newbold-Fox","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illana","family":"Leppert","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Vallee","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Vogel","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Tremblay-Mercier","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Frenette","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josee","family":"Frappier","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Kat","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Miron","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Wan","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mahar","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldina","family":"Carmo","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Theroux","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Dadar","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dufour","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Elyse","family":"Lafaille-Magnan","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Appleby","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Savard","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Tuwaig","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Petkova","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rioux","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00c3\u00a7ois","family":"Meyer","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"El-Khoury","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Gordon","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Giles","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Das","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seqian","family":"Wang","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulantha","family":"Mathotaarachchi","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Dubuc","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Lee","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beaudry","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gervais","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Page","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gonneaud","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00c3\u00bclebru","family":"Ayranci","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick","family":"Pascoal","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Desautels","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Benbouhoud","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice Farah","family":"Saint-Fort","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Verfaillie","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Farzin","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Salaciak","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tullo","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Vachon-Presseau","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie-Ann","family":"Daoust","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Kobe","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Spreng","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"McSweeney","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Nilsson","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Pishnamazi","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bedetti","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Hudon","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Greco","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Chapleau","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"St-Onge","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Boutin","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiya","family":"Geddes","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Jean","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sylvain","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Josee","family":"\u00c3\u2030lie","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Leblond-Baccichet","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Soucy","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazal","family":"Ozlen","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bailly","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bery","family":"Mohammediyan","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Chen","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana","family":"Remz","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Johnson","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorene","family":"Rentz","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Amariglio","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Blacker","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Buckley","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeer P.","family":"Chhatwal","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Dickerson","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Donovan","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Farrell","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gatchel","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmarie","family":"Guzman-Velez","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Jacobs","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos","family":"Jutten","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lois Gomez","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Marshall","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Oaoo","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmanuelle","family":"Pardilla-Delgado","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Price","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prokopis","family":"Prokopiou","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakeel","family":"Quiroz","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Reynolds","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schultz","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schultz","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sepulcre","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Skylar-Scott","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Vannini","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Vila-Castelar","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Sik","family":"Yang","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L","family":"Masters","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Ward","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fowler","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Martins","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Rainy-Smith","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Brown","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Laws","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Fripp","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bourgeat","sequence":"additional","affiliation":[{"name":"for the PREVENT-AD, HABS, and AIBL Research Groups"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"noi220046r1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease.","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"6","key":"noi220046r2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/S1474-4422(21)00066-1","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: recommendations of the International Working Group.","volume":"20","author":"Dubois","year":"2021","journal-title":"Lancet Neurol"},{"key":"noi220046r3","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.dadm.2018.01.005","article-title":"Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants.","volume":"10","author":"Lowe","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"issue":"4","key":"noi220046r4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.2174\/156720511795745348","article-title":"Asymptomatic Alzheimer\u2019s disease: a prodrome or a state of resilience?","volume":"8","author":"Driscoll","year":"2011","journal-title":"Curr Alzheimer Res"},{"issue":"3","key":"noi220046r5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"5","key":"noi220046r6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.acn.2008.06.004","article-title":"Utility of the RBANS in detecting cognitive impairment associated with Alzheimer\u2019s disease: sensitivity, specificity, and positive and negative predictive powers.","volume":"23","author":"Duff","year":"2008","journal-title":"Arch Clin Neuropsychol"},{"issue":"4","key":"noi220046r7","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.trci.2017.10.004","article-title":"Optimizing the preclinical Alzheimer\u2019s cognitive composite with semantic processing: the PACC5.","volume":"3","author":"Papp","year":"2017","journal-title":"Alzheimers Dement (N Y)"},{"issue":"8","key":"noi220046r8","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1001\/jamaneurol.2014.803","article-title":"The preclinical Alzheimer cognitive composite: measuring amyloid-related decline.","volume":"71","author":"Donohue","year":"2014","journal-title":"JAMA Neurol"},{"issue":"11","key":"noi220046r9","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules.","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"issue":"3","key":"noi220046r10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer's disease.","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"3","key":"noi220046r11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/ana.v62:3","article-title":"Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.","volume":"62","author":"Johnson","year":"2007","journal-title":"Ann Neurol"},{"issue":"pt 8","key":"noi220046r12","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1093\/brain\/aww139","article-title":"The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging.","volume":"139","author":"Gordon","year":"2016","journal-title":"Brain"},{"issue":"11","key":"noi220046r13","doi-asserted-by":"publisher","first-page":"e1190","DOI":"10.1212\/WNL.0000000000008905","article-title":"Intermediate flortaucipir uptake is associated with A\u00df-PET and CSF tau in asymptomatic adults.","volume":"94","author":"McSweeney","year":"2020","journal-title":"Neurology"},{"issue":"1","key":"noi220046r14","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease.","volume":"79","author":"Johnson","year":"2016","journal-title":"Ann Neurol"},{"issue":"1","key":"noi220046r15","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3233\/ADR-210005","article-title":"Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study: progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer\u2019s disease.","volume":"5","author":"Fowler","year":"2021","journal-title":"J Alzheimers Dis Rep"},{"issue":"3","key":"noi220046r16","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"noi220046r17","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.dib.2017.10.024","article-title":"Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data.","volume":"15","author":"Baker","year":"2017","journal-title":"Data Brief"},{"issue":"3","key":"noi220046r18","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease.","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"228","key":"noi220046r19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007941","article-title":"The A4 study: stopping AD before symptoms begin?","volume":"6","author":"Sperling","year":"2014","journal-title":"Sci Transl Med"},{"issue":"7618","key":"noi220046r20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u00df plaques in Alzheimer\u2019s disease.","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"issue":"5","key":"noi220046r21","doi-asserted-by":"publisher","first-page":"614","DOI":"10.2967\/jnumed.120.245423","article-title":"What is T+? a Gordian knot of tracers, thresholds, and topographies.","volume":"62","author":"Villemagne","year":"2021","journal-title":"J Nucl Med"},{"issue":"4","key":"noi220046r22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes.","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"issue":"6","key":"noi220046r23","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging.","volume":"128","author":"Crary","year":"2014","journal-title":"Acta Neuropathol"},{"key":"noi220046r24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neurobiolaging.2021.09.019","article-title":"Abnormal tau in amyloid PET negative individuals.","volume":"109","author":"Yoon","year":"2022","journal-title":"Neurobiol Aging"},{"issue":"7","key":"noi220046r25","doi-asserted-by":"publisher","first-page":"e975","DOI":"10.1212\/WNL.0000000000012586","article-title":"Frequency of biologically defined Alzheimer disease in relation to age, sex, APOE e4, and cognitive impairment.","volume":"96","author":"Therriault","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"noi220046r26","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/brain\/awz378","article-title":"Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age.","volume":"143","author":"Betthauser","year":"2020","journal-title":"Brain"},{"issue":"10","key":"noi220046r27","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1001\/jamaneurol.2019.1971","article-title":"Prevalence of biologically vs clinically defined Alzheimer spectrum entities using the National Institute on Aging-Alzheimer\u2019s Association research framework.","volume":"76","author":"Jack","year":"2019","journal-title":"JAMA Neurol"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2794941\/jamaneurology_strikwerdabrown_2022_oi_220046_1664471641.40423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T11:27:40Z","timestamp":1665401260000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2794941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2022.2379","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}