{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:31:26Z","timestamp":1790829086970,"version":"4.1.0"},"reference-count":52,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"Importance<\/jats:title>Physical activity is associated with cognitive health, even in autosomal dominant forms of dementia. Higher physical activity is associated with slowed cognitive and functional declines over time in adults carrying autosomal dominant variants for frontotemporal lobar degeneration (FTLD), but whether axonal degeneration is a potential neuroprotective target of physical activity in individuals with FTLD is unknown.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine the association between physical activity and longitudinal neurofilament light chain (NfL) trajectories in individuals with autosomal dominant forms of FTLD.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study included individuals from the ALLFTD Consortium, which recruited patients from sites in the US and Canada. Symptomatic and asymptomatic adults with pathogenic variants in one of 3 common genes associated with FTLD (GRN<\/jats:italic>, C9orf72<\/jats:italic>, or MAPT<\/jats:italic>) who reported baseline physical activity levels and completed annual blood draws were assessed annually for up to 4 years. Genotype, clinical measures, and blood draws were collected between December 2014 and June 2019; data were analyzed from August 2021 to January 2022. Associations between reported baseline physical activity and longitudinal plasma NfL changes were assessed using generalized linear mixed-effects models adjusting for baseline age, sex, education, functional severity, and motor symptoms.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Baseline physical activity levels reported via the Physical Activity Scale for the Elderly. To estimate effect sizes, marginal means were calculated at 3 levels of physical activity: 1 SD above the mean represented high physical activity, 0 SD represented average physical activity, and 1 SD below the mean represented low physical activity.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Annual plasma NfL concentrations were measured with single-molecule array technology.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 160 included FTLD variant carriers, 84 (52.5%) were female, and the mean (SD) age was 50.7 (14.7) years. A total of 51 (31.8%) were symptomatic, and 77 carried the C9orf72<\/jats:italic> variant; 39, GRN<\/jats:italic> variant; and 44, MAPT<\/jats:italic> variant. Higher baseline physical activity was associated with slower NfL trajectories over time. On average, NfL increased 45.8% (95% CI, 22.5 to 73.7) over 4 years in variant carriers. Variant carriers with high physical activity demonstrated 14.0% (95% CI, \u221222.7 to \u22124.3) slower NfL increases compared with those with average physical activity and 30% (95% CI, \u221252.2 to \u22128.8) slower NfL increases compared with those with low physical activity. Within genotype, C9orf72<\/jats:italic> and MAPT<\/jats:italic> carriers with high physical activity evidenced 18% to 21% (95% CI, \u221243.4 to \u22127.2) attenuation in NfL, while the association between physical activity and NfL trajectory was not statistically significant in GRN<\/jats:italic> carriers. Activities associated with higher cardiorespiratory and cognitive demands (sports, housework, and yardwork) were most strongly correlated with slower NfL trajectories (vs walking and strength training).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this study, higher reported physical activity was associated with slower progression of an axonal degeneration marker in individuals with autosomal dominant FTLD. Physical activity may serve as a primary prevention target in FTLD.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaneurol.2022.4178","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T16:02:48Z","timestamp":1668441768000},"page":"82","source":"Crossref","is-referenced-by-count":24,"title":["Association of Physical Activity With Neurofilament Light Chain Trajectories in Autosomal Dominant Frontotemporal Lobar Degeneration Variant Carriers"],"prefix":"10.1001","volume":"80","author":[{"given":"Kaitlin B.","family":"Casaletto","sequence":"first","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kornack","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily W.","family":"Paolillo","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"VandeBunte","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Lee","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Heuer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana M.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Petrucelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, Florida"},{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Boxer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania F.","family":"Gendron","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic, Jacksonville, Florida"},{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Rosen","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ALLFTD Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Apostolova","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Appleby","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Barmada","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Boeve","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Bordelon","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Botha","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bozoki","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Brushaber","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Clark","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Coppola","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Darby","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford C.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Dickson","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Domoto-Reilly","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Faber","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fagan","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Fields","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Forsberg","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Geschwind","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nupur","family":"Ghoshal","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Goldman","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Galasko","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitza","family":"Gavrilova","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania F.","family":"Gendron","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Grant","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew GH","family":"Hall","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Huang","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary W.","family":"Heuer","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ging-Yuek","family":"Hsiung","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Huey","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Irwin","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejal","family":"Kantarci","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kauer","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kerwin","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Knopman","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kornak","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kramer","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Kremers","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lapid","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argentina","family":"Lario Lago","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzee","family":"Lee","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Leger","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ljubenkov","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Litvan","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lucente","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Masdeux","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McGinnis","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mendez","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Mester","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi","family":"Onyike","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Belen","family":"Pascual","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Petrucelli","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Pressman","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Ramanan","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana Marisa","family":"Ramos","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghana","family":"Rao","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Rascovsky","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine P.","family":"Rankin","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Ritter","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Rojas","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Savica","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Syrjanen","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack C.","family":"Taylor","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawren","family":"VandeVrede","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weintraub","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Wong","sequence":"additional","affiliation":[{"name":"for the ALLFTD Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"10248","key":"noi220076r1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"issue":"9","key":"noi220076r2","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The projected effect of risk factor reduction on Alzheimer\u2019s disease prevalence.","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol"},{"issue":"11","key":"noi220076r3","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.jalz.2018.06.3059","article-title":"Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer\u2019s disease.","volume":"14","author":"M\u00fcller","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"1","key":"noi220076r4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/alz.v16.1","article-title":"Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.","volume":"16","author":"Casaletto","year":"2020","journal-title":"Alzheimers Dement"},{"key":"noi220076r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101591","article-title":"Optimal dose and type of exercise to improve cognitive function in older adults: a systematic review and Bayesian model-based network meta-analysis of RCTs.","volume":"76","author":"Gallardo-G\u00f3mez","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"10004","key":"noi220076r6","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia.","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"issue":"8","key":"noi220076r7","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia.","volume":"266","author":"Greaves","year":"2019","journal-title":"J Neurol"},{"issue":"1","key":"noi220076r8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00401-016-1564-y","article-title":"Neurofilament depletion improves microtubule dynamics via modulation of Stat3\/stathmin signaling.","volume":"132","author":"Yadav","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"35","key":"noi220076r9","doi-asserted-by":"publisher","first-page":"11043","DOI":"10.1523\/JNEUROSCI.1924-09.2009","article-title":"Neurofilaments bind tubulin and modulate its polymerization.","volume":"29","author":"Bocquet","year":"2009","journal-title":"J Neurosci"},{"issue":"21","key":"noi220076r10","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1212\/WNL.0000000000004667","article-title":"Serum neurofilament light in familial Alzheimer disease: a marker of early neurodegeneration.","volume":"89","author":"Weston","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"noi220076r11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13195-019-0472-5","article-title":"Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer\u2019s disease.","volume":"11","author":"Weston","year":"2019","journal-title":"Alzheimers Res Ther"},{"issue":"5","key":"noi220076r12","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1001\/jamaneurol.2016.6117","article-title":"Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease.","volume":"74","author":"Mattsson","year":"2017","journal-title":"JAMA Neurol"},{"issue":"9","key":"noi220076r13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1001\/jamaneurol.2019.1534","article-title":"Diagnostic value of cerebrospinal fluid neurofilament light protein in neurology: a systematic review and meta-analysis.","volume":"76","author":"Bridel","year":"2019","journal-title":"JAMA Neurol"},{"issue":"3","key":"noi220076r14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/acn3.290","article-title":"Plasma neurofilament light chain predicts progression in progressive supranuclear palsy.","volume":"3","author":"Rojas","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"issue":"18","key":"noi220076r15","doi-asserted-by":"publisher","first-page":"e2296","DOI":"10.1212\/WNL.0000000000011848","article-title":"Plasma neurofilament light for prediction of disease progression in familial frontotemporal lobar degeneration.","volume":"96","author":"Rojas","year":"2021","journal-title":"Neurology"},{"issue":"12","key":"noi220076r16","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S1474-4422(19)30354-0","article-title":"Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.","volume":"18","author":"van der Ende","year":"2019","journal-title":"Lancet Neurol"},{"issue":"4","key":"noi220076r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100607","article-title":"Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.","volume":"3","author":"Gendron","year":"2022","journal-title":"Cell Rep Med"},{"issue":"Pt 11","key":"noi220076r19","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/brain\/awn234","article-title":"Development of methodology for conducting clinical trials in frontotemporal lobar degeneration.","volume":"131","author":"Knopman","year":"2008","journal-title":"Brain"},{"issue":"1","key":"noi220076r20","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/alz.v16.1","article-title":"Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases.","volume":"16","author":"Ramos","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"7","key":"noi220076r21","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0895-4356(99)00049-9","article-title":"The Physical Activity Scale for the Elderly (PASE): evidence for validity.","volume":"52","author":"Washburn","year":"1999","journal-title":"J Clin Epidemiol"},{"key":"noi220076r22","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1471-2474-15-46","article-title":"Validity and reproducibility of the Physical Activity Scale for the Elderly (PASE) questionnaire for the measurement of the physical activity level in patients after total knee arthroplasty.","volume":"15","author":"Bolszak","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"noi220076r23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0895-4356(93)90053-4","article-title":"The Physical Activity Scale for the Elderly (PASE): development and evaluation.","volume":"46","author":"Washburn","year":"1993","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"noi220076r24","first-page":"186","article-title":"Stability and convergent validity of the Physical Activity Scale for the Elderly (PASE).","volume":"44","author":"Dinger","year":"2004","journal-title":"J Sports Med Phys Fitness"},{"issue":"1","key":"noi220076r25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2474-13-26","article-title":"Reliability and validity of the Physical Activity Scale for the Elderly (PASE) in patients with hip osteoarthritis.","volume":"13","author":"Svege","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"noi220076r26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/ggi.2008.8.issue-3","article-title":"Validity and reliability of the Physical Activity Scale for the Elderly (PASE) in Japanese elderly people.","volume":"8","author":"Hagiwara","year":"2008","journal-title":"Geriatr Gerontol Int"},{"issue":"1","key":"noi220076r27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/alz.v16.1","article-title":"Utility of the global CDR\u00ae plus NACC FTLD rating and development of scoring rules: data from the ARTFL\/LEFFTDS Consortium.","volume":"16","author":"Miyagawa","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"10","key":"noi220076r29","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1038\/s41591-022-01942-9","article-title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia.","volume":"28","author":"Staffaroni","year":"2022","journal-title":"Nat Med"},{"issue":"10","key":"noi220076r30","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.tics.2013.08.001","article-title":"Bridging animal and human models of exercise-induced brain plasticity.","volume":"17","author":"Voss","year":"2013","journal-title":"Trends Cogn Sci"},{"issue":"1","key":"noi220076r31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","article-title":"Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo.","volume":"124","author":"Farmer","year":"2004","journal-title":"Neuroscience"},{"issue":"8","key":"noi220076r32","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1093\/gerona\/glab094","article-title":"Associations between physical activity, blood-based biomarkers of neurodegeneration, and cognition in healthy older adults: the MAPT study.","volume":"76","author":"Raffin","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"noi220076r33","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.v13.1","article-title":"Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: resistance versus resilience?","volume":"13","author":"Memel","year":"2021","journal-title":"Alzheimers Dement (Amst)"},{"issue":"19","key":"noi220076r34","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1212\/WNL.0000000000000964","article-title":"Physical activity attenuates age-related biomarker alterations in preclinical AD.","volume":"83","author":"Okonkwo","year":"2014","journal-title":"Neurology"},{"issue":"7","key":"noi220076r35","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/s41374-019-0232-y","article-title":"The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases.","volume":"99","author":"Liu","year":"2019","journal-title":"Lab Invest"},{"issue":"3","key":"noi220076r36","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1007\/s13311-019-00749-w","article-title":"Exercise for brain health: an investigation into the underlying mechanisms guided by dose.","volume":"16","author":"Cabral","year":"2019","journal-title":"Neurotherapeutics"},{"key":"noi220076r37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3389\/fnhum.2016.00626","article-title":"Mediators of physical activity on neurocognitive function: a review at multiple levels of analysis.","volume":"10","author":"Stillman","year":"2016","journal-title":"Front Hum Neurosci"},{"key":"noi220076r38","doi-asserted-by":"publisher","DOI":"10.1002\/alz.v18.11","article-title":"Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.","author":"Casaletto","journal-title":"Alzheimers Dement"},{"issue":"2","key":"noi220076r39","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1523\/JNEUROSCI.1483-21.2021","article-title":"Microglial correlates of late life physical activity: relationship with synaptic and cognitive aging in older adults.","volume":"42","author":"Casaletto","year":"2022","journal-title":"J Neurosci"},{"issue":"6500","key":"noi220076r40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1126\/science.aaw2622","article-title":"Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.","volume":"369","author":"Horowitz","year":"2020","journal-title":"Science"},{"issue":"7889","key":"noi220076r41","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-021-04183-x","article-title":"Exercise plasma boosts memory and dampens brain inflammation via clusterin.","volume":"600","author":"De Miguel","year":"2021","journal-title":"Nature"},{"issue":"1","key":"noi220076r42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002487","article-title":"Immune-related genetic enrichment in frontotemporal dementia: an analysis of genome-wide association studies.","volume":"15","author":"Broce","year":"2018","journal-title":"PLoS Med"},{"issue":"2","key":"noi220076r43","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/WCO.0000000000000665","article-title":"Immunological signatures in frontotemporal lobar degeneration.","volume":"32","author":"Sirkis","year":"2019","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"noi220076r44","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3233\/JAD-180897","article-title":"Cardiorespiratory fitness and cognition: longitudinal associations in the FINGER study.","volume":"68","author":"Pentik\u00e4inen","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"noi220076r45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131647","article-title":"Dose-response of aerobic exercise on cognition: a community-based, pilot randomized controlled trial.","volume":"10","author":"Vidoni","year":"2015","journal-title":"PLoS One"},{"issue":"15","key":"noi220076r46","doi-asserted-by":"publisher","first-page":"e1298","DOI":"10.1212\/WNL.0000000000005290","article-title":"Midlife cardiovascular fitness and dementia: a 44-year longitudinal population study in women.","volume":"90","author":"H\u00f6rder","year":"2018","journal-title":"Neurology"},{"issue":"14","key":"noi220076r47","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1001\/archinte.161.14.1703","article-title":"A prospective study of physical activity and cognitive decline in elderly women: women who walk.","volume":"161","author":"Yaffe","year":"2001","journal-title":"Arch Intern Med"},{"key":"noi220076r48","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/(ISSN)1096-9861","article-title":"The effects of an enriched environment on the histology of the rat cerebral cortex.","volume":"123","author":"Diamond","year":"1964","journal-title":"J Comp Neurol"},{"key":"noi220076r49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-3-642-36232-3","article-title":"All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis.","volume":"15","author":"Vivar","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"issue":"8","key":"noi220076r50","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/cercor\/13.8.845","article-title":"Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex.","volume":"13","author":"Ehninger","year":"2003","journal-title":"Cereb Cortex"},{"issue":"1","key":"noi220076r51","doi-asserted-by":"publisher","first-page":"7841","DOI":"10.1038\/s41598-022-11557-2","article-title":"Circulating neurofilament is linked with morbid obesity, renal function, and brain density.","volume":"12","author":"Rebelos","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"noi220076r52","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.v14.1","article-title":"Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.","volume":"14","author":"Berry","year":"2022","journal-title":"Alzheimers Dement (Amst)"},{"key":"noi220076r28","first-page":"153","volume-title":"Unified Parkinson\u2019s Disease Rating Scale","author":"Fahn","year":"1987"},{"key":"noi220076r18","unstructured":"ARTFL LEFFTDS longitudinal frontotemporal lobar degeneration (ALLFTD). ClinicalTrials.gov identifier: NCT04363684. Updated May 12, 2022. Accessed June 12, 2022. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04363684"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2798586\/jamaneurology_casaletto_2022_oi_220076_1699042986.11384.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T16:04:13Z","timestamp":1699286653000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2798586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2022.4178","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}