{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:58:05Z","timestamp":1791622685146,"version":"4.3.4"},"reference-count":15,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:sec id=\"ab-nbr230003-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-nbr230003-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the frequency of MOG-IgA and associated clinical features in patients with demyelinating CNS disease and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-nbr230003-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This longitudinal study comprised 1 discovery and 1 confirmation cohort derived from 5 centers. Participants included patients with suspected or confirmed demyelinating diseases and healthy controls. MOG-IgA, MOG-IgG, and MOG-IgM were measured in serum samples and cerebrospinal fluid (CSF) of patients, who were assessed from September 2012 to April 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-nbr230003-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Frequency and clinical features of patients who were seropositive for MOG-IgA and double-seronegative for aquaporin 4 (AQP4) IgG and MOG-IgG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-nbr230003-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After the exclusion of 5 participants with coexisting AQP4-IgG and MOG-IgA, MOG-IgG, and\/or MOG-IgM, 1339 patients and 110 healthy controls were included; the median follow-up time was 39 months (range, 0-227 months). Of included patients with isolated MOG-IgA, 11 of 18 were female (61%), and the median age was 31.5 years (range, 3-76 years). Among patients double-seronegative for AQP4-IgG and MOG-IgG (1126\/1339; 84%), isolated MOG-IgA was identified in 3 of 50 patients (6%) with neuromyelitis optica spectrum disorder, 5 of 228 patients (2%) with other CNS demyelinating diseases, and 10 of 848 patients (1%) with multiple sclerosis but in none of the healthy controls (0\/110). The most common disease manifestation in patients seropositive for isolated MOG-IgA was myelitis (11\/17 [65%]), followed by more frequent brainstem syndrome (7\/16 [44%] vs 14\/75 [19%], respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.048), and infrequent manifestation of optic neuritis (4\/15 [27%] vs 46\/73 [63%], respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02) vs patients with MOG-IgG. Among patients fulfilling 2017 McDonald criteria for multiple sclerosis, MOG-IgA was associated with less frequent CSF-specific oligoclonal bands (4\/9 [44%] vs 325\/351 [93%], respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001) vs patients with multiple sclerosis who were MOG-IgG\/IgA seronegative. Further, most patients with isolated MOG-IgA presented clinical attacks after recent infection or vaccination (7\/11 [64%]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-nbr230003-9\">\n                    <jats:title>Conclusion and Relevance<\/jats:title>\n                    <jats:p>In this study, MOG-specific IgA was identified in a subgroup of patients who were double-seronegative for AQP4-\/MOG-IgG, suggesting that MOG-IgA may be a novel diagnostic biomarker for patients with CNS demyelination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamaneurol.2023.2523","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:00:44Z","timestamp":1691406044000},"page":"989","source":"Crossref","is-referenced-by-count":41,"title":["Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination"],"prefix":"10.1001","volume":"80","author":[{"given":"Ana Beatriz","family":"Ayroza Galv\u00e3o Ribeiro Gomes","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland"},{"name":"Departments of Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland"},{"name":"Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland"},{"name":"Departamento de Neurologia, Instituto Central, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Kulsvehagen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland"},{"name":"Departments of Biomedicine and 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