{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:07:20Z","timestamp":1793286440260,"version":"4.5.0"},"reference-count":25,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"Importance<\/jats:title>Patients with atrial fibrillation (AF) who have ischemic stroke despite taking oral anticoagulation therapy (OAT) have a very high risk of recurrence. Left atrial appendage occlusion (LAAO) is a mechanical stroke prevention strategy that may provide additional protection in patients with thromboembolic events under OAT.<\/jats:p><\/jats:sec>Objective<\/jats:title>To compare percutaneous LAAO with continuing OAT alone regarding stroke prevention in patients with AF who had a thromboembolic event despite taking OAT.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study was a propensity score\u2013matched comparison of the STR-OAC LAAO cohort, an international collaboration of 21 sites combining patients from multiple prospective registries of patients who underwent LAAO between 2010 and 2022. STR-OAC LAAO cohort patients who had follow-up longer than 3 months were propensity score\u2013matched to a previously published control cohort comprising patients from an established international collaboration of investigator-initiated prospective studies. This control cohort included patients with nonvalvular AF, recent ischemic stroke or transient ischemic attack, and follow-up longer than 3 months who were taking OAT before the index event. Analyses were adjusted for imbalances in gender, age, hypertension, diabetes, and CHA2 DS2-VASc score.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Left atrial appendage occlusion vs continuation of oral anticoagulation therapy alone (control group).<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was time to first ischemic stroke.<\/jats:p><\/jats:sec>Results<\/jats:title>Four hundred thirty-three patients from the STR-OAC LAAO cohort (mean [SD] age, 72 [9] years; 171 [39%] females and 262 [61%] males; mean [SD] CHA2 DS2-VASc score, 5.0 [1.6]) were matched to 433 of 1140 patients (38%) from the control group. During 2-year follow-up, 50 patients experienced ischemic stroke: an annualized event rate of 2.8% per patient-year in the STR-OAC LAAO group vs 8.9% per patient-year in the control group. Left atrial appendage occlusion was associated with a lower risk of ischemic stroke (hazard ratio, 0.33; 95% CI, 0.19-0.58; P<\/jats:italic>\u2009&amp;lt;\u2009.001) compared with the control group. After LAAO, OAT was discontinued in 290 patients (67%), and the remaining 143 patients (33%) continued OAT after LAAO as an adjunctive therapy.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In patients with nonvalvular AF and a prior thromboembolic event despite taking OAT, LAAO was associated with a lower risk of ischemic stroke compared with continued OAT alone. Randomized clinical trial data are needed to confirm that LAAO may be a promising treatment option for this population with a very high risk of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaneurol.2024.2882","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T15:32:10Z","timestamp":1727105530000},"page":"1150","source":"Crossref","is-referenced-by-count":33,"title":["Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation"],"prefix":"10.1001","volume":"81","author":[{"given":"Moniek","family":"Maarse","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands"},{"name":"Department of Cardiology, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Seiffge","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Werring","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology, UCL London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas V. A.","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands"},{"name":"Department of Cardiology, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"STR-OAC LAAO Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosmas","family":"Macha","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Takagi","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Tsivgoulis","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bonetti","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Arihiro","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Alberti","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"A","given":"Alexandros","family":"Polymeris","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Ambler","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Venti","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"H","given":"Leo","family":"Bonati","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"W","given":"Keith","family":"Muir","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamagami","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Thilemann","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Altavilla","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Peters","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Inoue","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bobinger","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Agnelli","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"M","given":"Martin","family":"Brown","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Sato","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Acciarresi","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"R","given":"Hans","family":"Jager","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bovi","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lyrer","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Marco","family":"De Marchis","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Peper","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Simard","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"and the STR-OAC LAAO Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen Registry, and Verona Registry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol W.","family":"Aarnink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands"},{"name":"Department of Cardiology, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Fierro","sequence":"additional","affiliation":[{"name":"De Gasperis Cardio Center, Interventional Cardiology Unit, Azienda Socio-Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, Azienda Socio-Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Beneduce","sequence":"additional","affiliation":[{"name":"IRCCS, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tondo","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology & Cardiac Pacing, Centro Cardiologico Monzino, IRCCS, Milan, Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology & Cardiac Pacing, Centro Cardiologico Monzino, IRCCS, Milan, Italy"},{"name":"Department of Cardiology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslaw","family":"Pracon","sequence":"additional","affiliation":[{"name":"Department of Coronary and Structural Heart Diseases, National Institute of Cardiology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Demkow,","sequence":"additional","affiliation":[{"name":"Department of Coronary and Structural Heart Diseases, National Institute of Cardiology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Zieli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Coronary and Structural Heart Diseases, National Institute of Cardiology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"de Backer","sequence":"additional","affiliation":[{"name":"Heart Center, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Korsholm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Erik","family":"Nielsen-Kudsk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Est\u00e9vez-Loureiro","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, University Hospital \u00c1lvaro Cunqueiro, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Caneiro-Queija","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, University Hospital \u00c1lvaro Cunqueiro, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Benito-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Le\u00f3n, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando P\u00e9rez","family":"de Prado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Le\u00f3n, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Salinas","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul H.","family":"Almakadma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[{"name":"Fondazione Toscana \u201cG. Monasterio,\u201d Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Romeo","sequence":"additional","affiliation":[{"name":"Fondazione Toscana \u201cG. Monasterio,\u201d Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Millan","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sant Pau Research institute (IIB Sant Pau), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabit","family":"Arzamendi","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sant Pau Research institute (IIB Sant Pau), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata M.","family":"Alla","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"Medical Clinic II, University Heart Center L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg \u2013 Kiel \u2013 L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Paitazoglou","sequence":"additional","affiliation":[{"name":"Medical Clinic II, University Heart Center L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg \u2013 Kiel \u2013 L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institut Clinic Cardiovascular, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cepas-Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institut Clinic Cardiovascular, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashaad","family":"Chothia","sequence":"additional","affiliation":[{"name":"St Joseph\u2019s Medical Center, Stockton, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon O.","family":"Badejoko","sequence":"additional","affiliation":[{"name":"St Joseph\u2019s Medical Center, Stockton, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AK Altona, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Spoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Providence Heart Institute, Missoula, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Maddux","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Providence Heart Institute, Missoula, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhael","family":"El-Chami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Emory University Hospital, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradhum","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Emory University Hospital, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Branca","sequence":"additional","affiliation":[{"name":"Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam S.","family":"Suradi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent F.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno J. W. M.","family":"Rensing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annaelle","family":"Zietz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Stroke Unit \u2013 Internal Vascular and Emergency Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Caso","sequence":"additional","affiliation":[{"name":"Stroke Unit \u2013 Internal Vascular and Emergency Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kallm\u00fcnzer","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neuroscience, Azienda Ospedaliera Universitaria Integrata, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen \u2013 Nuremberg (FAU), Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christchurch Hospital, Christchurch, New Zealand"},{"name":"New Zealand Brain Research Institute, Christchurch, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Engelter","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel, Switzerland"},{"name":"Neurology and Neurorehabilitation, University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Swaans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"5","key":"noi240055r1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in colaboration with the European Association of Cardio-Thoracic Surgery (EACTS).","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"issue":"1","key":"noi240055r2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/ana.25917","article-title":"Prior anticoagulation in patients with ischemic stroke and atrial fibrillation.","volume":"89","author":"Meinel","year":"2021","journal-title":"Ann Neurol"},{"issue":"6","key":"noi240055r3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1136\/jnnp-2021-328391","article-title":"Aetiology, secondary prevention strategies and outcomes of ischaemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation.","volume":"93","author":"Polymeris","year":"2022","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"noi240055r4","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/ana.25700","article-title":"Ischemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation.","volume":"87","author":"Seiffge","year":"2020","journal-title":"Ann Neurol"},{"issue":"20","key":"noi240055r5","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1093\/eurheartj\/ehad200","article-title":"Outcomes of patients with atrial fibrillation and ischemic stroke while on oral anticoagulation.","volume":"44","author":"Benz","year":"2023","journal-title":"Eur Heart J"},{"issue":"4","key":"noi240055r6","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1161\/STROKEAHA.119.027275","article-title":"Atrial fibrillation-associated ischemic stroke patients with prior anticoagulation have higher risk for recurrent stroke.","volume":"51","author":"Tanaka","year":"2020","journal-title":"Stroke"},{"issue":"10","key":"noi240055r7","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1136\/jnnp-2021-326166","article-title":"Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study.","volume":"92","author":"Yaghi","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"noi240055r8","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1161\/STROKEAHA.121.038239","article-title":"Recurrent ischemic stroke and bleeding in patients with atrial fibrillation who suffered an acute stroke while on treatment with nonvitamin K antagonist oral anticoagulants: the RENO-EXTEND study.","volume":"53","author":"Paciaroni","year":"2022","journal-title":"Stroke"},{"key":"noi240055r9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.575634","article-title":"Long-term anticoagulation in secondary ischemic stroke prevention: the prospective multicenter RESTAIC registry.","volume":"11","author":"Guti\u00e9rrez-Z\u00fa\u00f1iga","year":"2020","journal-title":"Front Neurol"},{"issue":"4","key":"noi240055r10","doi-asserted-by":"publisher","first-page":"e358","DOI":"10.1212\/WNL.0000000000207422","article-title":"Association of alternative anticoagulation strategies and outcomes in patients with ischemic stroke while taking a direct oral anticoagulant.","volume":"101","author":"Bonaventure Ip","year":"2023","journal-title":"Neurology"},{"issue":"2","key":"noi240055r11","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/0003-4975(95)00887-X","article-title":"Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation.","volume":"61","author":"Blackshear","year":"1996","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"noi240055r12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40001-018-0350-9","article-title":"Frequency of atrial thrombus formation in patients with atrial fibrillation under treatment with non-vitamin K oral anticoagulants in comparison to vitamin K antagonists: a systematic review and meta-analysis.","volume":"23","author":"Reers","year":"2018","journal-title":"Eur J Med Res"},{"issue":"11","key":"noi240055r13","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.echo.2014.08.016","article-title":"Prognostic significance of left atrial appendage \u201csludge\u201d in patients with atrial fibrillation: a new transesophageal echocardiographic thromboembolic risk factor.","volume":"27","author":"Lowe","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"issue":"5","key":"noi240055r14","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S0002-9149(96)00828-4","article-title":"Thromboembolic risks of left atrial thrombus detected by transesophageal echocardiogram.","volume":"79","author":"Leung","year":"1997","journal-title":"Am J Cardiol"},{"issue":"1","key":"noi240055r15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.rec.2019.02.013","article-title":"Left atrial appendage occlusion for stroke despite oral anticoagulation (resistant stroke): results from the Amplatzer Cardiac Plug registry.","volume":"73","author":"Cruz-Gonz\u00e1lez","year":"2020","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"8","key":"noi240055r16","first-page":"212","article-title":"Left atrial appendage occlusion as adjunctive therapy to anticoagulation for stroke recurrence.","volume":"31","author":"Freixa","year":"2019","journal-title":"J Invasive Cardiol"},{"key":"noi240055r17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijcard.2022.02.030","article-title":"Residual stroke risk after left atrial appendage closure in patients with prior oral anticoagulation failure.","volume":"354","author":"Pracon","year":"2022","journal-title":"Int J Cardiol"},{"issue":"3","key":"noi240055r18","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/joa3.12838","article-title":"Left atrial appendage occlusion after thromboembolic events or left atrial appendage sludge during anticoagulation therapy: is two better than one? real-world experience from a tertiary care hospital.","volume":"39","author":"Margonato","year":"2023","journal-title":"J Arrhythm"},{"issue":"13","key":"noi240055r19","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.4244\/EIJY19M08_01","article-title":"EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion: an update.","volume":"15","author":"Glikson","year":"2020","journal-title":"EuroIntervention"},{"issue":"1","key":"noi240055r20","first-page":"4","article-title":"Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies.","volume":"19","author":"Tzikas","year":"2017","journal-title":"Europace"},{"issue":"12","key":"noi240055r21","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1093\/eurheartj\/ehr488","article-title":"Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study.","volume":"33","author":"Friberg","year":"2012","journal-title":"Eur Heart J"},{"issue":"2","key":"noi240055r22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jacc.2010.09.024","article-title":"Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal\/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs\/Alcohol Concomitantly) score.","volume":"57","author":"Lip","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"noi240055r23","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1056\/NEJMoa2101897","article-title":"Left atrial appendage occlusion during cardiac surgery to prevent stroke.","volume":"384","author":"Whitlock","year":"2021","journal-title":"N Engl J Med"},{"issue":"13","key":"noi240055r24","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.jacc.2019.12.040","article-title":"The NCDR left atrial appendage occlusion registry.","volume":"75","author":"Freeman","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"noi240055r25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/S1474-4422(24)00037-1","article-title":"Secondary stroke prevention in people with atrial fibrillation: treatments and trials.","volume":"23","author":"Seiffge","year":"2024","journal-title":"Lancet Neurol"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2824065\/jamaneurology_maarse_2024_oi_240055_1731516279.70918.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T17:00:23Z","timestamp":1731517223000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2824065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2024.2882","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,1]]}}}