{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:12:56Z","timestamp":1793776376680,"version":"4.6.1"},"reference-count":25,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:sec id=\"ab-noi240095-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240095-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare (1) medical comorbidities affecting plasma biomarker concentrations, (2) imaging and clinical features, and (3) cognitive changes between plasma biomarker and PET discordant and concordant cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240095-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This multicenter cohort study, conducted between 2016 and 2023, included individuals with unimpaired cognition, mild cognitive impairment, or Alzheimer-type dementia, who had both amyloid \u03b2 (A\u03b2) PET imaging and plasma biomarkers. A subset of participants also underwent tau PET imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240095-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Participants were categorized into 4 groups based on their plasma and PET biomarker results: plasma\u2212\/PET\u2212, plasma+\/PET\u2212, plasma\u2212\/PET+, and plasma+\/PET+.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240095-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Clinical characteristics were compared between the 4 groups, focusing on the discordant groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240095-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2611 participants (mean [SD] age was 71.2 [8.7] years; 1656 female [63.4%]), of whom 124 additionally underwent tau PET, were included. Among the plasma biomarkers, phosphorylated tau (p-tau) 217 exhibited the highest concordance rate with A\u03b2 (2326 of 2571 [90.5%]) and tau (100 of 120 [83.3%]) PET. The p-tau217+\/A\u03b2 PET\u2212 group was older (mean [SD] age, 75.8 [7.2] years vs 70.0 [8.8] years;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001) with a higher prevalence of hypertension (56 of 152 [36.8%] vs 266 of 1073 [25.0%]), diabetes (40 of 152 [26.3%] vs 156 of 1059 [14.7%]), and chronic kidney disease (17 of 152 [11.2%] vs 21 of 1073 [2.0%]) compared with the p-tau217\u2212\/A\u03b2 PET\u2212 group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001 for all). Body mass index was higher in p-tau217\u2212\/A\u03b2 PET+ than in p-tau217+\/A\u03b2 PET+ (mean [SD], 24.1\u2009[2.8] vs 23.1\u2009[3.1], respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001; calculated as weight in kilograms divided by height in meters squared). The p-tau217+\/A\u03b2 PET\u2212 group had lower hippocampal volume (mean [SD], 2555.4\u2009[576.9] vs 2979.1\u2009[545.8];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001) and worse clinical trajectory compared with p-tau217\u2212\/A\u03b2 PET\u2212 (\u03b2\u2009=\u2009\u22120.53;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001). In contrast, tau PET discordant cases did not show significant differences in medical comorbidities or clinical outcomes compared with the p-tau217\u2212\/tau PET\u2212 group. Only the p-tau 217+\/tau PET+ group demonstrated faster cognitive deterioration compared with the p-tau 217\u2212\/tau PET\u2212 group (\u03b2\u2009=\u2009\u22121.66;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240095-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Results of this cohort study suggest that the mechanisms underlying the discordance between plasma biomarkers and PET findings may be multifaceted, underscoring the need to consider the temporal dynamics and biological variability of plasma biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamaneurol.2024.5263","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T11:32:47Z","timestamp":1739791967000},"page":"384","source":"Crossref","is-referenced-by-count":28,"title":["Temporal Dynamics and Biological Variability of Alzheimer Biomarkers"],"prefix":"10.1001","volume":"82","author":[{"given":"Jihwan","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongki","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"},{"name":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul, Republic of Korea"},{"name":"Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University. Seoul, Republic of Korea"},{"name":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"},{"name":"Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"},{"name":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul, Republic of Korea"},{"name":"Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University. Seoul, Republic of Korea"},{"name":"Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"},{"name":"Happymid Clinic, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeshin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangwon National University College of Medicine, Chuncheon-si, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Yeon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden"},{"name":"Department of Neurodegenerative Disease, UCL 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