{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:15:01Z","timestamp":1792703701512,"version":"4.5.0"},"reference-count":41,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:sec id=\"ab-noi240097-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>A leading cause of surgically remediable, drug-resistant focal epilepsy is focal cortical dysplasia (FCD). FCD is challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for FCD detection are limited by high numbers of false-positive predictions, hampering their clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240097-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and interpretability of graph neural networks in automatically detecting FCD lesions on MRI scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240097-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>In this multicenter diagnostic study, retrospective MRI data were collated from 23 epilepsy centers worldwide between 2018 and 2022, as part of the Multicenter Epilepsy Lesion Detection (MELD) Project, and analyzed in 2023. Data from 20 centers were split equally into training and testing cohorts, with data from 3 centers withheld for site-independent testing. A graph neural network (MELD Graph) was trained to identify FCD on surface-based features. Network performance was compared with an existing algorithm. Feature analysis, saliencies, and confidence scores were used to interpret network predictions. In total, 34 surface-based MRI features and manual lesion masks were collated from participants, 703 patients with FCD\u2013related epilepsy and 482 controls, and 57 participants were excluded during MRI quality control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240097-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Sensitivity, specificity, and positive predictive value (PPV) of automatically identified lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240097-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the test dataset, the MELD Graph had a sensitivity of 81.6% in histopathologically confirmed patients seizure-free 1 year after surgery and 63.7% in MRI\u2013negative patients with FCD. The PPV of putative lesions from the 260 patients in the test dataset (125 female [48%] and 135 male [52%]; mean age, 18.0 [IQR, 11.0-29.0] years) was 67% (70% sensitivity; 60% specificity), compared with 39% (67% sensitivity; 54% specificity) using an existing baseline algorithm. In the independent test cohort (116 patients; 62 female [53%] and 54 male [47%]; mean age, 22.5 [IQR, 13.5-27.5] years), the PPV was 76% (72% sensitivity; 56% specificity), compared with 46% (77% sensitivity; 47% specificity) using the baseline algorithm. Interpretable reports characterize lesion location, size, confidence, and salient features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-noi240097-9\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this study, the MELD Graph represented a state-of-the-art, openly available, and interpretable tool for FCD detection on MRI scans, with significant improvements in PPV. Its clinical implementation holds promise for early diagnosis and improved management of focal epilepsy, potentially leading to better patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamaneurol.2024.5406","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T11:34:59Z","timestamp":1740396899000},"page":"397","source":"Crossref","is-referenced-by-count":74,"title":["Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks"],"prefix":"10.1001","volume":"82","author":[{"given":"Mathilde","family":"Ripart","sequence":"first","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany"},{"name":"Institute of Computational Biology, Helmholtz Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan Z. J.","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering & Imaging Sciences, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Walger","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Bonn, Bonn, Germany"},{"name":"Department of Epileptology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Chen","sequence":"additional","affiliation":[{"name":"Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Bambino Ges\u00f9 Children\u2019s hospital, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Rossi-Espagnet","sequence":"additional","affiliation":[{"name":"Functional and Interventional Neuroimaging Unit, Bambino Ges\u00f9 Children\u2019s hospital, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Foldes","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhan","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Mo","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Likeman","sequence":"additional","affiliation":[{"name":"Bristol Royal Hospital for Children, Bristol, 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