{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:12:18Z","timestamp":1793293938887,"version":"4.5.0"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec id=\"ab-noi250016-4\"><jats:title>Importance<\/jats:title><jats:p>Diffusion-weighted imaging (DWI) lesions have been demonstrated in patients with subacute intracerebral hemorrhage (ICH), suggesting ischemic injury, which may be related to blood pressure (BP) reduction.<\/jats:p><\/jats:sec><jats:sec id=\"ab-noi250016-5\"><jats:title>Objective<\/jats:title><jats:p>To test the hypothesis that acute intensive BP lowering is associated with DWI lesions after ICH.<\/jats:p><\/jats:sec><jats:sec id=\"ab-noi250016-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial 2 (ICHADAPT-2) was a multicenter, randomized, open-label, blinded\u2013end point trial. Between November 2012 and August 2022, patients with ICH presenting within 6 hours of onset were randomized to a systolic BP (SBP) target of less than 140 mm Hg or less than 180 mm Hg. The trial was conducted at 3 comprehensive stroke centers in Canada and Australia, including 1 telestroke referral hub and 1 community stroke hospital. A total of 162 patients with acute ICH were randomized. The primary analysis population was restricted to those undergoing DWI at 48 hours.<\/jats:p><\/jats:sec><jats:sec id=\"ab-noi250016-7\"><jats:title>Intervention<\/jats:title><jats:p>Patients were randomly assigned to an acute SBP target of less than 140 mm Hg or less than 180 mm Hg.<\/jats:p><\/jats:sec><jats:sec id=\"ab-noi250016-8\"><jats:title>Main Outcome and Measure<\/jats:title><jats:p>The primary end point was the incidence of acute DWI lesions on brain magnetic resonance imaging obtained 48\u2009\u00b1\u200912 hours after randomization.<\/jats:p><\/jats:sec><jats:sec id=\"ab-noi250016-9\"><jats:title>Results<\/jats:title><jats:p>DWI was obtained in 79 (48% female) patients with a mean (SD) age of 71 (13) years and median baseline ICH volume of 11.2 (range, 0.5-122.2) mL. The median times from onset to randomization and DWI were 3.17 (range, 0.7-14.6) hours and 51.6 (range, 17.0-121.4) hours, respectively. Mean (SD) baseline SBP was 183 (22) mm Hg in the less than 140 mm Hg target group and 181 (28) mm Hg in the less than 180 mm Hg target group. Mean SBP was lower over the 48-hour period after randomization in the less than 140 mm Hg group (mean difference, 18.9 mm Hg [95% CI, 17.6-20.2]; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001). DWI lesions were detected in 13 of 42 patients (31%) in the less than 140 mm Hg group and 14 of 37 patients (38%) in the less than 180 mm Hg group (odds ratio, 0.74 [95% CI, 0.12-4.64]; <jats:italic>P<\/jats:italic>\u2009=\u2009.32). The median number of DWI lesions (1 [95% CI, 1-10] vs 1.5 [95% CI, 1-10]; <jats:italic>P<\/jats:italic>\u2009=\u2009.26) and total DWI lesion volume (0.1 [95% CI, 0.01-41.3] mL vs 0.3 [95% CI, 0.02-2.03] mL; <jats:italic>P<\/jats:italic>\u2009=\u2009.17) were not different in the less than 140 mm Hg and less than 180 mm Hg groups.<\/jats:p><\/jats:sec><jats:sec id=\"ab-noi250016-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>DWI lesion frequency and volume were unaffected by intensive antihypertensive therapy. These results support the safety of early BP reduction in acute ICH.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaneurol.2025.0586","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T15:31:16Z","timestamp":1745249476000},"page":"543","source":"Crossref","is-referenced-by-count":20,"title":["Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage"],"prefix":"10.1001","volume":"82","author":[{"given":"Ken S.","family":"Butcher","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Buck","sequence":"additional","affiliation":[{"name":"Division of Neurology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar","family":"Dowlatshahi","sequence":"additional","affiliation":[{"name":"Division of Neurology, 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