{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:56:01Z","timestamp":1794020161301,"version":"4.8.0"},"reference-count":26,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"\n Importance<\/jats:title>\n The optimal dose, safety, and efficacy of intra-arterial tenecteplase after successful reperfusion by endovascular thrombectomy for large vessel occlusion (LVO) is unknown.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the dose-dependent adverse events and signals of efficacy of intra-arterial tenecteplase in LVO after successful reperfusion with thrombectomy, defined as an Extended Treatment in Cerebral Infarction score of 2b-3.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This open-label, blinded-outcome assessment trial, incorporating a 14\u2009+\u20098 dose-escalation (phase 1b, nonrandomized) and dose-expansion (phase 2a, randomized) design, was conducted in China between 2023 and 2024, with follow-up continuing through November 2024. This was a multicenter clinical trial including patients with LVO and successful reperfusion within 24 hours of last known well.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n In phase 1b, intra-arterial tenecteplase, 0.0313, 0.0625, 0.1250, 0.1875 mg\/kg; in phase 2a, intra-arterial tenecteplase 0.0313 or 0.0625 mg\/kg, or control (without intra-arterial thrombolysis).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome in phase 1b was symptomatic intracranial hemorrhage (sICH) within 24 hours. The primary outcome in phase 2a was 90-day no-disability outcome (modified Rankin Scale score 0-1).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 205 patients (phase 1b: 48, phase 2a: 157) were enrolled and analyzed. The median (IQR) age was 71 (60-77) years, and 113 (55.1%) were male. In phase 1b, 1 of 14 and 2 of 22 patients with sICH were observed at dose tiers 0.0313 and 0.0625 mg\/kg, respectively. Three of 12 patients had sICH at dose tier 0.1250 mg\/kg, exceeding the prespecified safety threshold (\n P<\/jats:italic>\n \u2009=\u2009.04). In phase 2a, eligible patients were randomly assigned to receive tenecteplase, 0.0313 mg\/kg (n\u2009=\u200946) and 0.0625 mg\/kg (n\u2009=\u200946), and 65 patients composed the control group. The primary outcome occurred in 22 of 65 patients (33.8%) in the control group, 17 of 46 patients (37.0%) in the tenecteplase, 0.0313 mg\/kg, group (adjusted risk ratio [RR] vs control, 0.85; 95% CI, 0.54-1.35;\n P<\/jats:italic>\n \u2009=\u2009.50), and 20 of 46 patients (43.5%) in the tenecteplase, 0.0625 mg\/kg, group (adjusted RR, 1.15; 95% CI, 0.73-1.80;\n P<\/jats:italic>\n \u2009=\u2009.55). No significant difference in the safety outcomes was observed among the 3 groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Results of this phase 1 and 2 randomized clinical trial reveal that adjunctive intra-arterial tenecteplase dosages of 0.0313 mg\/kg or 0.0625 mg\/kg after successful reperfusion in patients with anterior circulation LVO showed adequate safety to advance to larger trials to determine the potential therapeutic benefits.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ChiCTR.org.cn Identifier:\n ChiCTR2300073787<\/jats:ext-link>\n and\n ChiCTR2400080624<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaneurol.2025.2036","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T03:30:16Z","timestamp":1751686216000},"page":"895","source":"Crossref","is-referenced-by-count":40,"title":["Intra-Arterial Tenecteplase After Successful Reperfusion in Large Vessel Occlusion Stroke"],"prefix":"10.1001","volume":"82","author":[{"given":"Xianhua","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"},{"name":"Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zigong Third People\u2019s Hospital, Zigong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jingzhou Central Hospital, Jingzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maojun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The People\u2019s Hospital of QianNan, Duyun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"},{"name":"Department of Neurology, Qujing First People\u2019s Hospital, Qujing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gulin People\u2019s Hospital, Gulin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Three Gorges Hospital affiliated to Chongqing University, Wanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guilin People\u2019s Hospital, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology, JiuJiang No. 1 People\u2019s Hospital, Jiujiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chongzhou People\u2019s Hospital, Chongzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xionglin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ya\u2019an People\u2019s Hospital, Ya\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Dali Prefecture, Dali, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqiang","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangyuan Central Hospital, Guangyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chengdu Second People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengguang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Puren Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunxue","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chongqing Changshou District People\u2019s Hospital, Changshou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The People\u2019s Hospital of Jianyang, Jianyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third People\u2019s Hospital of Chengdu, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qianjiang Central Hospital of Chongqing, Qianjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chongqing Hechuan District People\u2019s Hospital, Hechuan, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dazhou Central Hospital, Dazhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchuang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbo","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhou","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Health Statistics, College of Preventive Medicine, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duolao","family":"Wang","sequence":"additional","affiliation":[{"name":"Global Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"UPMC Stroke Institute, Departments of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh N.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Departments of Radiology & Neurology, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital (Southwest Hospital), Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"12","key":"noi250043r1","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/S1474-4422(23)00277-6","article-title":"Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission.","volume":"22","author":"Feigin","year":"2023","journal-title":"Lancet Neurol"},{"issue":"4","key":"noi250043r2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S1474-4422(18)30500-3","article-title":"Stroke in China: advances and challenges in epidemiology, prevention, and management.","volume":"18","author":"Wu","year":"2019","journal-title":"Lancet Neurol"},{"issue":"12","key":"noi250043r3","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for health care professionals from the American Heart Association\/American Stroke Association.","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"issue":"8","key":"noi250043r4","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging.","volume":"378","author":"Albers","year":"2018","journal-title":"N Engl J Med"},{"issue":"1","key":"noi250043r5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct.","volume":"378","author":"Nogueira","year":"2018","journal-title":"N Engl J Med"},{"issue":"24","key":"noi250043r6","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1056\/NEJMoa2000120","article-title":"Thrombectomy for stroke in the public health care system of Brazil.","volume":"382","author":"Martins","year":"2020","journal-title":"N Engl J Med"},{"issue":"10029","key":"noi250043r7","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischemic stroke: a meta-analysis of individual patient data from 5 randomized trials.","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"issue":"5","key":"noi250043r8","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/neurintsurg-2018-014127","article-title":"eTICI reperfusion: defining success in endovascular stroke therapy.","volume":"11","author":"Liebeskind","year":"2019","journal-title":"J Neurointerv Surg"},{"issue":"8","key":"noi250043r9","doi-asserted-by":"publisher","first-page":"e790","DOI":"10.1212\/WNL.0000000000013210","article-title":"Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow).","volume":"98","author":"Ng","year":"2022","journal-title":"Neurology"},{"issue":"2","key":"noi250043r10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/0271678X20954929","article-title":"Tissue no-reflow despite full recanalization following thrombectomy for anterior circulation stroke with proximal occlusion: a clinical study.","volume":"41","author":"Ter Schiphorst","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"noi250043r11","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14631","article-title":"No-reflow after stroke reperfusion therapy: an emerging phenomenon to be explored.","volume":"30","author":"Jia","year":"2024","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"noi250043r12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1161\/STROKEAHA.107.492348","article-title":"Comparison of intraarterial and intravenous thrombolysis for ischemic stroke with hyperdense middle cerebral artery sign.","volume":"39","author":"Mattle","year":"2008","journal-title":"Stroke"},{"issue":"9","key":"noi250043r13","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1001\/jama.2022.1645","article-title":"Effect of intra-arterial alteplase vs placebo following successful thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: the CHOICE randomized clinical trial.","volume":"327","author":"Ren\u00fa","year":"2022","journal-title":"JAMA"},{"issue":"9","key":"noi250043r14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209903","article-title":"Tenecteplase vs alteplase in acute ischemic stroke within 4.5 hours: a systematic review and meta-analysis of randomized trials.","volume":"103","author":"Palaiodimou","year":"2024","journal-title":"Neurology"},{"issue":"3","key":"noi250043r16","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/svn-2020-000385","article-title":"Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of the management of high-risk population.","volume":"5","author":"Wang","year":"2020","journal-title":"Stroke Vasc Neurol"},{"issue":"13","key":"noi250043r17","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.","volume":"359","author":"Hacke","year":"2008","journal-title":"N Engl J Med"},{"issue":"9","key":"noi250043r18","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1161\/STROKEAHA.120.030173","article-title":"Symptomatic intracranial hemorrhage after mechanical thrombectomy in Chinese ischemic stroke patients: the ASIAN score.","volume":"51","author":"Zhang","year":"2020","journal-title":"Stroke"},{"key":"noi250043r19","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2147\/DDDT.S76135","article-title":"Sample sizes in dosage investigational clinical trials: a systematic evaluation.","volume":"9","author":"Huang","year":"2015","journal-title":"Drug Des Dev Ther"},{"issue":"17","key":"noi250043r20","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1158\/1078-0432.CCR-16-0592","article-title":"Bayesian optimal interval design: a simple and well-performing design for phase 1 oncology trials.","volume":"22","author":"Yuan","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"7","key":"noi250043r21","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A modified Poisson regression approach to prospective studies with binary data.","volume":"159","author":"Zou","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"8","key":"noi250043r22","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/ijs.12364","article-title":"An improved method for simple, assumption-free ordinal analysis of the modified Rankin Scale using generalized odds ratios.","volume":"9","author":"Churilov","year":"2014","journal-title":"Int J Stroke"},{"issue":"1","key":"noi250043r23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/10543406.2023.2275759","article-title":"Adjusted win ratio using the inverse probability of treatment weighting.","volume":"35","author":"Wang","year":"2025","journal-title":"J Biopharm Stat"},{"key":"noi250043r24","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241286983","article-title":"Adjunctive intra-arterial tenecteplase after successful endovascular thrombectomy in patients with large vessel occlusion stroke (POST-TNK): dtudy rationale and design.","author":"Huang","journal-title":"Eur Stroke J"},{"key":"noi250043r25","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2024-003318","article-title":"Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicenter, open-label, blinded end-point, prospective, randomized trial.","author":"Huo","journal-title":"Stroke Vasc Neurol"},{"issue":"2","key":"noi250043r26","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/STROKEAHA.124.048846","article-title":"Safety of adjunctive intraarterial tenecteplase following mechanical thrombectomy: the ALLY pilot trial.","volume":"56","author":"Zaidi","year":"2025","journal-title":"Stroke"},{"key":"noi250043r15","doi-asserted-by":"crossref","unstructured":"Hou? X, Huang? J, Guo? C, . Safety and efficacy of adjunctive intra-arterial tenecteplase following successful thrombectomy in patients with large vessel occlusion: a phase 1\/2 randomized clinical trial.? medRxiv Preprint posted online November 18, 2024. doi:10.1101\/2024.11.17.24317449","DOI":"10.1101\/2024.11.17.24317449"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2836176\/jamaneurology_hou_2025_oi_250043_1756927756.90411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:01:20Z","timestamp":1757343680000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2836176"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2025.2036","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}