{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:55:51Z","timestamp":1775087751571,"version":"3.50.1"},"reference-count":13,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2025,12,1]]},"DOI":"10.1001\/jamaneurol.2025.2419","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:30:48Z","timestamp":1759159848000},"page":"1211","source":"Crossref","is-referenced-by-count":1,"title":["Rethinking the Menopause Transition and Multiple Sclerosis Progression"],"prefix":"10.1001","volume":"82","author":[{"given":"Jennifer S.","family":"Graves","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego"},{"name":"Rady Children\u2019s Pediatric MS Center, San Diego VA MS Center, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Tintor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology and Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic\/Manresa, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"1","key":"ned250006r1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S1474-4422(22)00289-7","article-title":"Multiple sclerosis progression: time for a new mechanism-driven framework.","volume":"22","author":"Kuhlmann","year":"2023","journal-title":"Lancet Neurol"},{"issue":"1","key":"ned250006r2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S1474-4422(22)00184-3","article-title":"Ageing and multiple sclerosis.","volume":"22","author":"Graves","year":"2023","journal-title":"Lancet Neurol"},{"issue":"pt 12","key":"ned250006r3","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1093\/brain\/awt281","article-title":"Sex as a determinant of relapse incidence and progressive course of multiple sclerosis.","volume":"136","author":"Kalincik","year":"2013","journal-title":"Brain"},{"issue":"1","key":"ned250006r4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/clinem\/dgaa764","article-title":"The menopause transition: signs, symptoms, and management options.","volume":"106","author":"Santoro","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ned250006r5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1385\/ENDO:26:3:297","article-title":"Ovarian aging and the perimenopausal transition: the paradox of endogenous ovarian hyperstimulation.","volume":"26","author":"Prior","year":"2005","journal-title":"Endocrine"},{"key":"ned250006r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.07.1139","article-title":"Contribution of the rate of change of antim\u00fcllerian hormone in estimating time to menopause for late reproductive-age women.","author":"Freeman","year":"2012","journal-title":"Fertil Steril"},{"issue":"3","key":"ned250006r7","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1212\/WNL.0000000000004843","article-title":"Ovarian aging is associated with gray matter volume and disability in women with MS.","volume":"90","author":"Graves","year":"2018","journal-title":"Neurology"},{"key":"ned250006r8","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.3538","article-title":"Menopause impact on multiple sclerosis disability progression.","author":"Bridge","journal-title":"JAMA Neurol"},{"issue":"6","key":"ned250006r9","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1210\/jc.2003-030824","article-title":"Menopause transition: annual changes in serum hormonal patterns over the menstrual cycle in women during a nine-year period prior to menopause.","volume":"89","author":"Landgren","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"ned250006r10","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1093\/aje\/kwq481","article-title":"Bias due to left truncation and left censoring in longitudinal studies of developmental and disease processes.","volume":"173","author":"Cain","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"4","key":"ned250006r11","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1111\/ene.14782","article-title":"Menopause does not modify disability trajectories in a longitudinal cohort of women with clinically isolated syndrome and multiple sclerosis followed from disease onset.","volume":"29","author":"Otero-Romero","year":"2022","journal-title":"Eur J Neurol"},{"issue":"2","key":"ned250006r12","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa185","article-title":"Reproductive history and progressive multiple sclerosis risk in women.","volume":"2","author":"Zeydan","year":"2020","journal-title":"Brain Commun"},{"issue":"4","key":"ned250006r13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3109\/13697137.2015.1020484","article-title":"Long-term health consequences of premature or early menopause and considerations for management.","volume":"18","author":"Faubion","year":"2015","journal-title":"Climacteric"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2839353\/jamaneurology_graves_2025_ed_250006_1764183391.4037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:01:08Z","timestamp":1765209668000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2839353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2025.2419","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}