{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:35:38Z","timestamp":1792690538355,"version":"4.5.0"},"reference-count":28,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"\n Importance<\/jats:title>\n Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score\u2013based definitions of pretreatment disabling deficits.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This is a secondary analysis of the TEMPO-2 (Tenecteplase vs Standard of Care for Minor Ischemic Stroke With Proven Occlusion) randomized clinical trial, conducted between April 27, 2015, and January 19, 2024. Patients were followed up for 90 days. The TEMPO-2 trial was conducted across 48 sites globally among patients with minor ischemic stroke (NIHSS 0-5) and proven intracranial occlusion within 12 hours of onset. Patients were divided into having nondisabling vs disabling syndromes at presentation as per the TREAT Task Force consensus. Other established definitions of disabling stroke from the ARAMIS trial and the National Institute of Neurological Disorders and Stroke trial were explored. Data analysis was completed from July 2024 to September 2024.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Intravenous tenecteplase (0.25 mg\/kg) vs nonthrombolytic standard of care.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was a return to baseline modified Rankin scale score at 90 days.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 886 enrolled patients, 2 withdrew consent and 884 were included in the secondary analysis. Among 884 patients analyzed (369 women [41.7%]; median [IQR] age, 72 [61-80] years), 100 (11.3%) had disabling and 784 (88.7%) had nondisabling deficits. Patients with disabling deficits had higher median (IQR) baseline NIHSS scores (4 [3-5] vs 2 [1-3]), later presentations (onset to hospital arrival time: 288 [153-412] minutes vs 133 [70-310] minutes), and longer onset to treatment time (411 [307-560] minutes vs 278 [170-462] minutes) than those with nondisabling deficits. In the disabling group, the primary outcome following tenecteplase, compared with standard of care, occurred in 29 patients (54.7%) vs 32 patients (68.1%) (adjusted risk ratio [aRR], 0.81; 95% CI, 0.60-1.10). This neutral treatment effect was consistent in patients without disabling deficits (280 [73.9%] vs 306 [75.6%]; aRR, 0.98; 95% CI, 0.91-1.07;\n P<\/jats:italic>\n for interaction\u2009=\u2009.32).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this secondary analysis of the TEMPO-2 randomized clinical trial, current definitions of disabling symptoms based on NIHSS score at baseline did not modify the neutral treatment effect of intravenous tenecteplase in patients with minor stroke and intracranial occlusion. Together with converging evidence comparing intravenous thrombolysis to nonthrombolytic standard of care, this analysis suggests the need to reevaluate thrombolysis in minor disabling stroke.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT02398656<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaneurol.2025.4152","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:31:26Z","timestamp":1761579086000},"page":"1243","source":"Crossref","is-referenced-by-count":9,"title":["Thrombolysis With Tenecteplase for Minor Disabling Stroke"],"prefix":"10.1001","volume":"82","author":[{"given":"Yiran","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Buck","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kausik","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Countess of Chester Hospital NHS Foundation Trust, Chester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Clarke","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospitals, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M. C.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Box Hill Hospital, Eastern Health, Melbourne, Victoria, Australia"},{"name":"Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Hunter","sequence":"additional","affiliation":[{"name":"University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"The O\u2019Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin M.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Williams","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons Ireland (RCSI) University of Medicine and Health Sciences and Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce C. V.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar","family":"Dowlatshahi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken S.","family":"Butcher","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Queen\u2019s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ivan","family":"Wiggam","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital, Belfast, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Kleinig","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith W.","family":"Muir","sequence":"additional","affiliation":[{"name":"School of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Zerna","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"St\u00e4dtisches Klinikum Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia S.","family":"Field","sequence":"additional","affiliation":[{"name":"Vancouver Stroke Program, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y. X.","family":"Yu","sequence":"additional","affiliation":[{"name":"Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Roffe","sequence":"additional","affiliation":[{"name":"Stroke Research, Keele University, Stoke-on-Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Demchuck","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Neurology, Liverpool Hospital, University of New South Wales South Western Sydney Clinical School, Liverpool, New South Wales, Australia"},{"name":"Ingham Institute of Applied Medical Research, Liverpool, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Bazan","sequence":"additional","affiliation":[{"name":"Botucatu Medical School, S\u00e3o Paulo State University, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Ankolekar","sequence":"additional","affiliation":[{"name":"Department of Neurology, King\u2019s College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Acute Multidisciplinary Imaging and Interventional Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijoy K.","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Mandzia","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Pille","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Moinhos de Vento, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Mater University Hospital, School of Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Marko","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishita","family":"Singh","sequence":"additional","affiliation":[{"name":"Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Vatanpour","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrico O.","family":"Lima","sequence":"additional","affiliation":[{"name":"Stroke Unit, Hospital Geral De Fortaleza, Fortaleza-ce, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Catanese","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MacKenzie","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Ghia","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"},{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology, St John\u2019s of God Hospital Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefen","family":"Greisenegger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelagh B.","family":"Coutts","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TEMPO-2 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Salluzzi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Blenkin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Dueck","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Doram","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Kenney","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Ryckborst","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Bohn","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Collier","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Taylor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Cord","family":"Lethebe","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Molina","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Hart","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kent","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee H.","family":"Martin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Whiteley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anitha","family":"Jambula","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Sage","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Toussaint","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Save","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Lee","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesreen","family":"Laham","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Sultan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimen","family":"Moussaddy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Deepak","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amith","family":"Sitaram","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lockey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Micielli","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babawale","family":"Arabambi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Graham","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Tham","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysi","family":"Bogiatzi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Doshi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kim","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Vasquez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Singh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Tse","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Harrison","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Smith","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka","family":"Teleg","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Klourfeld","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Klein","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Sebastian","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Evans","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janka","family":"Hegedus","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Kromm","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Lin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Ignacio","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Ghavami","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madawi","family":"Ismail","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Moores","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Andre","family":"Panzini","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Boyko","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Almekhlafi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Newcommon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Maraj","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oje","family":"Imoukhuede","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Volny","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stys","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Couillard","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Ojha","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Eswaradass","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Joundi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramana","family":"Appireddy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Singh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ria","family":"Asuncion","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Muir","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadanand","family":"Dey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Mansoor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchea","family":"Wasyliw","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Nagendra","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Hu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shorog","family":"Althubait","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew","family":"Chen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simerpreet","family":"Bal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Gaal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Peters","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucharita","family":"Ray","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surbhi","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Fu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Villaluna","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveva","family":"Maclean","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Princess","family":"King-Azote","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Ma","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Plecash","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Murphy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathon","family":"Gorman","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Wilson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Zhou","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Benavente","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Teal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Yip","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharan","family":"Mann","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Dewar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Demetroff","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rany","family":"Shamloul","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeccah","family":"Beardshaw","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Roberts","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Blaquiere","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Stotts","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Shamy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Bereznyakova","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fahed","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Alesefir","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Camden","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzy","family":"Lavoie","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Hache","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Collard","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Mackey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gosselin-Lefebvre","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Verreault","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Beauchamp","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Lambourn","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Khaw","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Mai","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Sposato","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Bres","family":"Bullrich","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Azarpazhooh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fridman","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Kapoor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisia","family":"Southwell","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Bardi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idris","family":"Fatakdawala","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneesha","family":"Kamra","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Lopes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla","family":"Popel","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Norouzi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Liu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Liddy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bismah","family":"Ghoari","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hawkes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Enriquez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gladstone","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Manosalva Alzate","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houman","family":"Khosravani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hopyan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim","family":"Son","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Boulos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"AlHamind","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Swartz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Murphy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Reiter","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tess","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinaya","family":"Bhandari","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Penn","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Good","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Penn","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Naylor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheilah","family":"Frost","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Casaubon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cayley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Akthar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Kalman","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Crellin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Relu","family":"Wiegner","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoba","family":"Singh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Stewart","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"To","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Pikula","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Jaigobin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico","family":"Carpani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Silver","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Janssen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Schaafsma","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"del Campo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alskaini","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phavalan","family":"Rajendram","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Fairall","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonny","family":"Granfield","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Crawford","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juline","family":"Jabs","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"White","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leka","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Piquette","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao","family":"Nguyen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nomani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wagner","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Alrohimi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Butt","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atlantic","family":"D'Souza","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikram","family":"Gajurel","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Vekhande","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha","family":"Kamble","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrapet","family":"Kalashyan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Lloret","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mowad","family":"Benguzzi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazeem","family":"Arsalan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noman","family":"Ishaque","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezan","family":"Ashayeriahmadabad","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Samiento","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed","family":"Hosseini","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharish","family":"Kazi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhabrata","family":"Das","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripthi","family":"Sugumar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Zafar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Selchen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Kostyrko","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Muccilli","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Saposnik","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheyanne","family":"Vandervelde","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Ratnayake","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"McMillan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Katsanos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Shoamanesh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Sahlas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Medvedev","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishaya","family":"Naidoo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesselin","family":"Todorov","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassanain","family":"Toma","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskiran","family":"Brar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Horton","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Shand","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Weatherby","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Jin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Durafourt","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Jalini","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Gardner","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Tyson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Junk","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Foster","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kala","family":"Bolt","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sylvain","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharleen","family":"Maley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Urroz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissa","family":"Peeling","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kelly","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Whelan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan","family":"Cooley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Teitelbaum","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achraf","family":"Boutayeb","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Moore","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Cole","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Waxman","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Ben-Amor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Sanchez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Khalil","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Nehme","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Legault","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Tampieri","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ehrensperger","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Vieira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cortes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Angle","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Hannouche","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Badawy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Werner","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Wieszmuellner","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Langer","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gisold","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidemarie","family":"Zach","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Rommer","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Macher","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Blechinger","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Marik","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Series","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Baumgartinger","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Krebs","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Koski","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saija","family":"Eirola","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terhi","family":"Ivanoff","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Erakanto","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura-Leena","family":"Kupari","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerli","family":"Sibolt","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan","family":"Panula","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Tomppo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjaana","family":"Tiainen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Ahlstrom","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Martinez","family":"Majander","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Suomalainen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"Raty","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Levi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Spratt","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enda","family":"Kerr","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Allen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Kaauwai","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Belevski","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Russell","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Ormond","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Chew","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Loiselle","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Royan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Hughes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Garcia","family":"Esperon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pepper","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdi","family":"Miteff","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"He","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Lycett","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myintzu","family":"Min","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Murray","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Pavey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Starling","family":"de Barros","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Gangadharan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dunkerton","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Waller","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Canento","family":"Sanchez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Wellings","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Edmonds","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri-Ann","family":"Whittaker","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Ewing","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Lee","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowena","family":"Singkang","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"McDonald","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Santos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Shin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jackson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Tsoleridis","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fisicchia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Parsons","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikitha","family":"Shenoy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Smith","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos","family":"Sharobeam","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balabanski","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Park","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Pavlin-Premri","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edrich","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fana","family":"Alemseged","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Ng","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Zhao","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Beharry","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Lyn","family":"Ng","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Williamson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Wong","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Li","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kwan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Valente","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf","family":"Yassi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignan","family":"Yogendrakumar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"McNamara","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Buchanan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"McCarthy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Thomas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Stephens","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mang","family":"Chung","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Tang","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila","family":"Pachani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narelle","family":"Stuart","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Lee","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Frost","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Busch","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwathi","family":"Menon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko","family":"Borojevic","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Linton","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Callaly","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Garcia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Dewey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Liu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Chen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Nowak","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien","family":"To","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Lizak","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oneil","family":"Bhalala","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Park","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Tan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Martins","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Cody","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Forbes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Tu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyi","family":"Ooi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew","family":"Dang","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ling","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cranefield","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Drew","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Tan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Kurunawai","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Harvey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavenia","family":"Cagi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logesh","family":"Palanikumar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaddy","family":"El-Masri","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bailey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berzenn","family":"Urbi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Rapier","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haylee","family":"Berrill","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"McEvoy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Dunning","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumole","family":"Kuriakose","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Chad","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sapaen","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Sabet","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Shah","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Yeow","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Lilley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Ward","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Mozhy","family":"Mahizhnan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lynch","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Coveney","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Tobin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McCabe","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Marnane","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Murphy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Large","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Moynihan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Boyle","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Sanjuan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Sanchis","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olalla","family":"Pancorbo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sala","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Garcia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Garcia-Tornel","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Juega","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pagola","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Santana","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Requena","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Muchada","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Olive","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rubiera","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Deck","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prudencio","family":"Lozano","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Boned","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Arenillas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gomez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F J Reyes","family":"Munoz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Gomez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sanz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Garcia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Penacoba","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ramos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M de Lera","family":"Alfonso","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Leal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Feliu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pardo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ramirez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Murillo Hernandez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Lopez","family":"Dominguez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Terceno","family":"Izaga","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"Reina","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Viturro","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Bojaryn","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Vera","family":"molina","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Silva","family":"Blas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Siew","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherwin","family":"Agustin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Seet","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Tu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Murray","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Welch","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Hatherley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Day","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Smith","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"MacRae","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Mitchell","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammad","family":"Mahmood","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Elliot","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Neilson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viveka","family":"Biswas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Brown","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Simister","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lewis","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ashton","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Black","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Robinson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azra","family":"Banaras","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Cahoy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Raingold","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Marinescu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ndifreke","family":"Atang","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Bason","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Francia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Muhammad","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabaa","family":"Obarey","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shez","family":"Feerick","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Werring","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Perry","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeethu","family":"Joseph","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jithen","family":"Benjamin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Quinn","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Jhoots","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Teal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Ford","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Harston","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjit","family":"Bains","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivie","family":"Gbinigie","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Mathieson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Irons","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Schulz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Sim","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hayter","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Kennedy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Binnie","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Priestley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Ghatala","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Stratton","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Blight","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Davies","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Duffy","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Roberts","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Homer","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Roberts","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Dodd","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Cawley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Martin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Leason","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cotgreave","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Taylor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arumugam","family":"Nallasivan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Haider","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Webster","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Halse","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gil","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Martin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biji","family":"Joseph","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cabrera","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divia","family":"Jose","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Man","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Aquino","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leony","family":"Sebastian","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Osterdahl","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mini","family":"Matthew","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Ike","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bello","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wilding","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodel","family":"Fuentes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupal","family":"Shah","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Mashate","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulsi","family":"Patel","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchechi","family":"Nwanguma","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Dave","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El-Masry","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambreen","family":"Sheikh","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Dawson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Haber","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Lee","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Drumm","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Roberts","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Kalladka","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Taylor","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Rounis","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Vonberg","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieuan","family":"Jenkins","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Blagojevic","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jithin","family":"George","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kwan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoun","family":"Saeed","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Evans","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haji-Coll","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Tsuda","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Sayed","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narmathey","family":"Thanbirajah","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Winterkron","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oishik","family":"Raha","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Vittay","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabail","family":"Karim","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaridh","family":"Smail","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabaa","family":"Gauhar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Kalam","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa","family":"Elmamoun","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangam","family":"Malani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Pralhad","family":"Kelavkar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohaa","family":"Jamil","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Auger","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Matar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Hiden","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resti","family":"Varquez","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Ferdinand","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan","family":"Sanyal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernie","family":"Smith","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidiogo","family":"Okechukwu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elieen","family":"Fox","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Collins","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Courtney","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Tauro","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Patterson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McShane","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerallt","family":"Roberts","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"McIImoyle","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"McGuire","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fearon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gordon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Willmot","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Isaacs","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lucas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Smith","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Dews","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Bates","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Lawrence","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Heeley","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vruti","family":"Patel","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Chin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Sims","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Littleton","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jattinder","family":"Khaira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurdow","family":"Nadar","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kieliszkowska","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Sari","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Domingos","family":"Belo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Manolo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Aeron-Thomas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Doheny","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Garcia","family":"Pardo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Recaman","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tibajia","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Aissa","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Bayhonan","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"Conway","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Bhalla","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushka","family":"Engineer","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Nouvakis","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Theochari","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Boyle","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Teo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"King-Robson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar","family":"Law","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Sztriha","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Benger","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mena","family":"Farag","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owain","family":"Williams","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Alsukhni","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Heller","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas","family":"Meenakshisundaram","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Yu","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee","family":"Mah","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Zachariah","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"McGovern","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshi","family":"Iqbal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Day","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mitchell-Douglas","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobbin","family":"Francis","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Punjabivaryani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Anonuevo","family":"Reyes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathide","family":"Pauls","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Anonuevo","family":"Reyes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Buck","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hedstrom","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Kirkland","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen","family":"Wilkes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Newham","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Fleming","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Martins","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Fleck","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Franca","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Chwal","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Oldoni","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mantovani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovani","family":"Noll","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laisa","family":"Zanella","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Soma","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Secchi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyllians","family":"Borelli","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Marques Pontes Neto","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunna","family":"Rimoli","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Henrique","family":"da Cunha Silva","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila Aparecida","family":"Machado Galvao Mondin","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Barbosa Cerantola","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Imthon","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Esaki","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Leticia Amorim","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Pazini","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Massote Fontanini","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Matinez Rubio","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Milani","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Teixeira","family":"dos Santos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Dias","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico","family":"Alves","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Gustavo","family":"Riccioppa Rodrigues","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Santos Ferreira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Pena Pereira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"Morillos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millene","family":"Camilo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otavio","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"ds Cruz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pegorer Santos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Winckler","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli Thomaz","family":"De Souza","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Aparecido Muondo","family":"Bonome","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Fabiano","family":"Barbosa dos Santos","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Modolo","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Cesar","family":"dos Santos Moreira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Teodoro","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Cury Silva","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Braga","family":"Cruz Guedes de Morais","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Vieira","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mendes","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Paulo","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"for the TEMPO-2 Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"11","key":"noi250073r1","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1161\/STROKEAHA.111.613208","article-title":"Outcomes in mild or rapidly improving stroke not treated with intravenous recombinant tissue-type plasminogen activator: findings from Get With The Guidelines-Stroke.","volume":"42","author":"Smith","year":"2011","journal-title":"Stroke"},{"issue":"11","key":"noi250073r2","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nrneurol.2013.174","article-title":"Mild acute ischaemic stroke\u2013the case for thrombolytic therapy.","volume":"9","author":"Guerrero","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"9958","key":"noi250073r3","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0140-6736(14)60584-5","article-title":"Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.","volume":"384","author":"Emberson","year":"2014","journal-title":"Lancet"},{"issue":"2","key":"noi250073r4","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1001\/jama.2018.8496","article-title":"Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits: the PRISMS randomized clinical trial.","volume":"320","author":"Khatri","year":"2018","journal-title":"JAMA"},{"issue":"24","key":"noi250073r5","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1001\/jama.2023.7827","article-title":"Dual antiplatelet therapy vs alteplase for patients with minor nondisabling acute ischemic stroke: the ARAMIS randomized clinical trial.","volume":"329","author":"Chen","year":"2023","journal-title":"JAMA"},{"issue":"12","key":"noi250073r7","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association.","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"issue":"1","key":"noi250073r8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/cjn.2022.344","article-title":"Canadian stroke best practice recommendations: acute stroke management, 7th edition practice guidelines update, 2022.","volume":"51","author":"Heran","year":"2024","journal-title":"Can J Neurol Sci"},{"issue":"1","key":"noi250073r9","doi-asserted-by":"publisher","first-page":"I","DOI":"10.1177\/2396987321989865","article-title":"European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke.","volume":"6","author":"Berge","year":"2021","journal-title":"Eur Stroke J"},{"issue":"10444","key":"noi250073r10","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1016\/S0140-6736(24)00921-8","article-title":"Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial.","volume":"403","author":"Coutts","year":"2024","journal-title":"Lancet"},{"issue":"7","key":"noi250073r11","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1136\/jnnp-2014-308401","article-title":"Outcome of patients with occlusions of the internal carotid artery or the main stem of the middle cerebral artery with NIHSS score of less than 5: comparison between thrombolysed and non-thrombolysed patients.","volume":"86","author":"Heldner","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"noi250073r12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070996","article-title":"Proximal arterial occlusion in acute ischemic stroke with low NIHSS scores should not be considered as mild stroke.","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS ONE"},{"issue":"7","key":"noi250073r13","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1177\/17474930241253702","article-title":"A randomized controlled trial of tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2): rational and design of a multicenter, randomized open-label clinical trial.","volume":"19","author":"Singh","year":"2024","journal-title":"Int J Stroke"},{"issue":"24","key":"noi250073r14","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke.","volume":"333","author":"National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group","year":"1995","journal-title":"N Engl J Med"},{"issue":"9","key":"noi250073r15","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1161\/STROKEAHA.113.000878","article-title":"Review, historical context, and clarifications of the NINDS rt-PA stroke trials exclusion criteria: part 1: rapidly improving stroke symptoms.","volume":"44","author":"Levine","year":"2013","journal-title":"Stroke"},{"issue":"5","key":"noi250073r16","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1161\/01.CIR.94.5.1167","article-title":"Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. a statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association.","volume":"94","author":"Adams","year":"1996","journal-title":"Circulation"},{"issue":"3","key":"noi250073r17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.annemergmed.2005.02.013","article-title":"Recombinant tissue plasminogen activator for minor strokes: the National Institute of Neurological Disorders and stroke rt-PA stroke study experience.","volume":"46","author":"National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group","year":"2005","journal-title":"Ann Emerg Med"},{"issue":"3","key":"noi250073r18","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1001\/jamaneurol.2024.4688","article-title":"Prourokinase vs standard care for patients with mild ischemic stroke: the PUMICE randomized clinical trial.","volume":"82","author":"Xiong","year":"2025","journal-title":"JAMA Neurol"},{"key":"noi250073r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2023.120706","article-title":"Best medical management versus intravenous thrombolysis for mild non-disabling ischemic stroke: a prospective noninferiority registry study.","volume":"451","author":"Cao","year":"2023","journal-title":"J Neurol Sci"},{"issue":"1","key":"noi250073r20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001306","article-title":"Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.","volume":"4","author":"Choi","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"noi250073r21","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1111\/cns.14124","article-title":"Intravenous thrombolysis versus antiplatelet therapy in minor stroke patients with large vessel occlusion.","volume":"29","author":"Duan","year":"2023","journal-title":"CNS Neurosci Ther"},{"issue":"9065","key":"noi250073r22","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/S0140-6736(97)04011-7","article-title":"The international stroke trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke.","volume":"349","author":"International Stroke Trial Collaborative Group","year":"1997","journal-title":"Lancet"},{"issue":"9066","key":"noi250073r23","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0140-6736(97)04010-5","article-title":"CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke.","volume":"349","author":"Chen","year":"1997","journal-title":"Lancet"},{"issue":"6","key":"noi250073r24","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1161\/01.STR.31.6.1240","article-title":"Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40 000 randomized patients from the Chinese acute stroke trial and the international stroke trial. on behalf of the CAST and IST collaborative groups.","volume":"31","author":"Chen","year":"2000","journal-title":"Stroke"},{"issue":"12","key":"noi250073r25","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1001\/jamaneurol.2019.2531","article-title":"Outcomes associated with clopidogrel-aspirin use in minor stroke or transient ischemic attack: a pooled analysis of clopidogrel in high-risk patients with acute non-disabling cerebrovascular events (CHANCE) and platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trials.","volume":"76","author":"Pan","year":"2019","journal-title":"JAMA Neurol"},{"issue":"2","key":"noi250073r26","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/01.STR.0000110219.67054.BF","article-title":"Differential pattern of tissue plasminogen activator-induced proximal middle cerebral artery recanalization among stroke subtypes.","volume":"35","author":"Molina","year":"2004","journal-title":"Stroke"},{"issue":"6","key":"noi250073r27","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1161\/STROKEAHA.117.016728","article-title":"\u201cGood outcome\u201d isn\u2019t good enough: cognitive impairment, depressive symptoms, and social restrictions in physically recovered stroke patients.","volume":"48","author":"Kapoor","year":"2017","journal-title":"Stroke"},{"issue":"7","key":"noi250073r28","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1161\/STROKEAHA.125.049454","article-title":"COSMOS: interrater and intrarater reliability study of a novel outcome measure.","volume":"56","author":"Goyal","year":"2025","journal-title":"Stroke"},{"key":"noi250073r6","unstructured":"Stroke Foundation. Australian and New Zealand living clinical guidelines for stroke management. Accessed March 21, 2025. https:\/\/informme.org.au\/en\/Guidelines\/Clinical-Guidelines-for-Stroke-Management"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2840388\/jamaneurology_zhang_2025_oi_250073_1764183363.43166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:01:18Z","timestamp":1765209678000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2840388"}},"subtitle":["Secondary Analysis of the TEMPO-2 Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2025.4152","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}