{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:46:04Z","timestamp":1793619964872,"version":"4.5.0"},"reference-count":6,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>This cohort study evaluates the association between age at onset and family history of Parkinson disease in patients who carry pathogenic variants.<\/jats:p>","DOI":"10.1001\/jamaneurol.2026.1112","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:30:20Z","timestamp":1778513420000},"page":"711","source":"Crossref","is-referenced-by-count":5,"title":["Genetic Testing by Age at Onset in Parkinson Disease"],"prefix":"10.1001","volume":"83","author":[{"given":"Alexander","family":"Balck","sequence":"first","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"Section for Movement Disorders, Department of Neurology, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Juliane","family":"Vollstedt","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Westenberger","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M.","family":"Lange","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Trinh","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Kasten","sequence":"additional","affiliation":[{"name":"University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Lohmann","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"Section for Movement Disorders, Department of Neurology, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Trenkwalder","sequence":"additional","affiliation":[{"name":"Paracelsus-Elena-Klinik, Kassel, Germany"},{"name":"Department of Neurology, University Medical Center G\u00f6ttingen, Germany"},{"name":"Department of Neurosurgery, University Medical Center, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brit","family":"Mollenhauer","sequence":"additional","affiliation":[{"name":"Paracelsus-Elena-Klinik, Kassel, Germany"},{"name":"Department of Neurology, University Medical Center G\u00f6ttingen, Germany"},{"name":"Department of Neurosurgery, University Medical Center, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Alcalay","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamalini Ghosh","family":"Galvelis","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Foundation, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Beck","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Foundation, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bauer","sequence":"additional","affiliation":[{"name":"CENTOGENE, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inke R.","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Biometrie und Statistik, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the Global Parkinson\u2019s Genetics Program (GP2), the ROPAD Study Group, and the PDGENEration Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"8","key":"nld260006r1","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1002\/mds.29500","article-title":"Genetic testing in Parkinson\u2019s disease.","volume":"38","author":"Pal","year":"2023","journal-title":"Mov Disord"},{"issue":"1","key":"nld260006r2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/ene.12022","article-title":"EFNS\/MDS-ES\/ENS [corrected] recommendations for the diagnosis of Parkinson\u2019s disease.","volume":"20","author":"Berardelli","year":"2013","journal-title":"Eur J Neurol"},{"issue":"8","key":"nld260006r3","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1093\/brain\/awae188","article-title":"Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson\u2019s disease study.","volume":"147","author":"Westenberger","year":"2024","journal-title":"Brain"},{"issue":"8","key":"nld260006r4","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1093\/brain\/awae142","article-title":"Parkinson\u2019s disease variant detection and disclosure: PD GENEration, a North American study.","volume":"147","author":"Cook","year":"2024","journal-title":"Brain"},{"issue":"5","key":"nld260006r5","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/mds.27352","article-title":"Genotype-phenotype relations for the parkinson\u2019s disease genes parkin, PINK1, DJ1: MDSGene systematic review.","volume":"33","author":"Kasten","year":"2018","journal-title":"Mov Disord"},{"issue":"1","key":"nld260006r6","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41531-023-00526-9","article-title":"Elucidating causative gene variants in hereditary Parkinson\u2019s disease in the Global Parkinson\u2019s Genetics Program (GP2).","volume":"9","author":"Lange","year":"2023","journal-title":"NPJ Parkinsons Dis"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2848939\/jamaneurology_balck_2026_ld_260006_1782409434.74479.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:00:27Z","timestamp":1783954827000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2848939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2026.1112","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}