{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:04:12Z","timestamp":1793070252592,"version":"4.5.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"\n Importance<\/jats:title>\n Postherpetic neuralgia (PHN) is a refractory neuropathic pain condition with limited therapeutic options. Although electroacupuncture has demonstrated potential analgesic effects, high-quality evidence from rigorous randomized clinical trials remains limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine whether electroacupuncture reduces pain severity compared with sham electroacupuncture and evaluate its safety in patients with PHN.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This multicenter, randomized, sham-controlled clinical trial took place at 7 tertiary hospitals in China and enrolled participants from October 2020 to July 2022, with the last follow-up in September 2022. Data analyses were performed from August to December 2025. Participants with PHN aged 45 to 75 years and moderate to severe pain (11-point Numeric Rating Scale [NRS-11] score \u22654) were recruited. Of 1072 patients screened, 624 were excluded. The remaining 448 participants were randomized to electroacupuncture (n\u2009=\u2009225) or sham electroacupuncture (n\u2009=\u2009223); 383 participants (85.49%) completed the trial.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Twenty sessions of electroacupuncture or sham electroacupuncture over 4 weeks, followed by a 4-week posttreatment follow-up.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was the change in the NRS-11 scores from baseline to week 4, with responders defined as participants achieving a 30% or more reduction in NRS-11 scores.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 448 participants, the mean (SD) age was 63.19 (9.26) years, 233 (52.01%) were male, and 215 were female (47.99%). At week 4, the electroacupuncture group had a greater decrease in the NRS-11 scores (\u22121.52) than the sham electroacupuncture group (\u22120.99) with an adjusted mean difference of \u22120.53 (95% CI, \u22120.61 to \u22120.43;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001), and the responder rate was significantly higher in the electroacupuncture group (46.68%) than in the sham electroacupuncture group (24.28%) (adjusted risk difference, 22.40%; 95% CI, 13.02%-31.79%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). These treatment benefits persisted through a 1-month follow-up; no clinically significant adverse events were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Among patients with PHN in this study, electroacupuncture provided a statistically significant reduction in pain severity, increased responder rates, and improved pain-related functional outcomes. These benefits suggest that electroacupuncture may be a useful nonpharmacological option for integrated management of PHN.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT04560361<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaneurol.2026.1443","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:02:00Z","timestamp":1779807720000},"page":"667","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Electroacupuncture on Postherpetic Neuralgia"],"prefix":"10.1001","volume":"83","author":[{"given":"Lu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"},{"name":"Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, School of Acupuncture-moxibustion and 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Danyang Hospital of Traditional Chinese Medicine, Teaching Hospital of Nanjing University of Chinese Medicine, Danyang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 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Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"},{"name":"Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, School of Acupuncture-moxibustion and Tuina, Health and Prevention, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"16","key":"noi260030r1","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1056\/NEJMcp1403062","article-title":"Clinical practice. postherpetic neuralgia.","volume":"371","author":"Johnson","year":"2014","journal-title":"N Engl J 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