{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:24:59Z","timestamp":1792729499587,"version":"4.5.0"},"reference-count":10,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>This cohort study examines data for a large population-based cohort to identify and characterize any cases of primary Epstein-Barr virus infection that occurred after the onset of multiple sclerosis.<\/jats:p>","DOI":"10.1001\/jamaneurol.2026.2514","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:00:53Z","timestamp":1785769253000},"page":"1027","source":"Crossref","is-referenced-by-count":2,"title":["Multiple Sclerosis Onset Preceding Epstein-Barr Virus Infection"],"prefix":"10.1001","volume":"83","author":[{"given":"Dalia L.","family":"Rotstein","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"St Michael\u2019s Hospital, Unity Health Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Maxwell","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada"},{"name":"ICES, Toronto, Ontario, Canada"},{"name":"School of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Tremlett","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manav V.","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"St Michael\u2019s Hospital, Unity Health Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Everett","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Ann","family":"Marrie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"NS Health, Halifax, Nova Scotia, Canada"},{"name":"Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"nld260011r1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S1474-4422(22)00471-9","article-title":"Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy.","volume":"22","author":"Aloisi","year":"2023","journal-title":"Lancet Neurol"},{"issue":"6578","key":"nld260011r2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"issue":"5","key":"nld260011r3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1001\/jamaneurol.2026.0240","article-title":"Epstein-Barr virus antibodies to differentiate multiple sclerosis from other neuroinflammatory diseases.","volume":"83","author":"Vietzen","year":"2026","journal-title":"JAMA Neurol"},{"issue":"6","key":"nld260011r4","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1002\/ana.26062","article-title":"Multiple sclerosis is rare in Epstein-Barr virus-seronegative children with central nervous system inflammatory demyelination.","volume":"89","author":"Nourbakhsh","year":"2021","journal-title":"Ann Neurol"},{"issue":"21","key":"nld260011r5","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1056\/NEJMcp1001116","article-title":"Infectious mononucleosis.","volume":"362","author":"Luzuriaga","year":"2010","journal-title":"N Engl J Med"},{"issue":"8118","key":"nld260011r6","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/S0140-6736(79)91171-1","article-title":"False-positive serology in infectious mononucleosis.","volume":"1","author":"Schumacher","year":"1979","journal-title":"Lancet"},{"issue":"3","key":"nld260011r7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1017\/cjn.2017.301","article-title":"Establishing the incidence and prevalence of multiple sclerosis in Saskatchewan.","volume":"45","author":"Al-Sakran","year":"2018","journal-title":"Can J Neurol Sci"},{"issue":"7900","key":"nld260011r8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41586-022-04432-7","article-title":"Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.","volume":"603","author":"Lanz","year":"2022","journal-title":"Nature"},{"issue":"2","key":"nld260011r9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.cell.2025.12.046","article-title":"EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation.","volume":"189","author":"Wang","year":"2026","journal-title":"Cell"},{"issue":"1","key":"nld260011r10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/brain\/awad374","article-title":"Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis.","volume":"147","author":"Grut","year":"2024","journal-title":"Brain"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2852245\/jamaneurology_rotstein_2026_ld_260011_1790958469.97295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:00:26Z","timestamp":1791817226000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2852245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2026.2514","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}