{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:35:29Z","timestamp":1792690529199,"version":"4.5.0"},"reference-count":39,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Neurol"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"\n Importance<\/jats:title>\n Patients with branch atheromatous disease (BAD)\u2013related stroke are predisposed to early neurological deterioration (END) and disability. However, large-scale clinical trials focused on the prevention of the deterioration and recurrent stroke in this population are currently lacking.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of intensive antiplatelet therapy combining the tirofiban with aspirin for patients with BAD-related stroke.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This randomized clinical trial was the multicenter, double-blind, randomized, placebo-controlled STRATEGY trial, conducted across 38 hospitals in China. Participants were patients with BAD-related acute ischemic stroke confirmed by magnetic resonance imaging within 48 hours of symptom onset were eligible for enrollment. Enrollment occurred from November 15, 2022, to November 19, 2024, with a 90-day follow-up period for all participants. Investigators, patients, and outcome assessors were blinded to treatment assignment.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Eligible participants were randomized to receive either intravenous tirofiban or placebo (0.4 \u00b5g\/kg\/min for 30 minutes followed by 0.1 \u00b5g\/kg\/min for 24 hours). All patients received a 300-mg loading dose of aspirin on the day of randomization, followed by 100 mg daily until day 90.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary efficacy end point was END within 7 days or new stroke within 90 days. The primary safety end point was moderate or severe bleeding.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 1378 patients with acute ischemic stroke screened for eligibility, 408 were excluded for ineligible imaging findings, other exclusion criteria, lack of consent, or additional reasons, leaving 970 participants who underwent randomization (486 assigned to tirofiban plus aspirin, 484 to placebo plus aspirin). The median (IQR) age was 63.0 (56.0-70.0) years; 607 patients (62.6%) were male and 363 (37.4%) female. The incidence of the primary efficacy end point was 79 patients (17.1%) in the tirofiban group and 89 (19.6%) in the placebo group (hazard ratio, 0.88; 95% CI, 0.65-1.19;\n P<\/jats:italic>\n \u2009=\u2009.39). The incidence of the primary safety end point was 1 of 486 patients (0.2%) in the tirofiban group and 0 patients in the placebo group (\n P<\/jats:italic>\n \u2009&amp;gt;\u2009.99).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n This study found that in patients with BAD-related stroke, intravenous tirofiban combined with aspirin did not significantly reduce the risk of END or stroke compared with aspirin alone, nor was it associated with an increased risk of moderate or severe bleeding.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT05310968<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaneurol.2026.2855","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:30:29Z","timestamp":1788190229000},"page":"956","source":"Crossref","is-referenced-by-count":3,"title":["Tirofiban for Branch Atheromatous Disease\u2013Related Stroke"],"prefix":"10.1001","volume":"83","author":[{"given":"Yicong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangxinyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Bath","sequence":"additional","affiliation":[{"name":"Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Claiborne","family":"Johnston","sequence":"additional","affiliation":[{"name":"University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"INSERM U1266, Institute of Psychiatry and Neuroscience of Paris (IPNP), Universit\u00e9 Paris Cit\u00e9, Paris, France"},{"name":"GHU Paris Psychiatrie et Neurosciences, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"National Center for Neurological Disorders, Beijing, China"},{"name":"Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Advanced Innovation Center for Human Brain Protection, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"National Center for Neurological Disorders, Beijing, China"},{"name":"Advanced Innovation Center for Human Brain Protection, Beijing, China"},{"name":"Beijing Laboratory of Oral Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"STRATEGY Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caijun","family":"Zhao","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Qiu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqin","family":"Yang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhuo","family":"Zang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Kang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panbing","family":"Huang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wusheng","family":"Lu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zheng","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Shangguan","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanwei","family":"Wang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Li","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Cui","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Fang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiting","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqi","family":"Liu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengguang","family":"Song","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huqing","family":"Li","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Shen","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfang","family":"Xie","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xing","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Li","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Du","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Ma","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Xu","sequence":"additional","affiliation":[{"name":"for the STRATEGY Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"noi260054r1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.","volume":"23","author":"GBD 2021 Nervous System Disorders Collaborators","year":"2024","journal-title":"Lancet Neurol"},{"issue":"3","key":"noi260054r2","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1161\/STROKEAHA.114.007466","article-title":"Neuroimaging markers for early neurologic deterioration in single small subcortical infarction.","volume":"46","author":"Jeong","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"noi260054r3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/1747493016677982","article-title":"Blood biomarkers associated with neurological deterioration in patients with acute penetrating artery territory infarction: a multicenter prospective observational study.","volume":"13","author":"Kawano","year":"2018","journal-title":"Int J Stroke"},{"issue":"1","key":"noi260054r4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/17474930241273685","article-title":"Early neurological deterioration in acute lacunar ischemic stroke: systematic review of incidence, mechanisms, and prospects for treatment.","volume":"20","author":"Werring","year":"2025","journal-title":"Int J Stroke"},{"issue":"9","key":"noi260054r5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1056\/NEJMoa1204133","article-title":"Effects of clopidogrel added to aspirin in patients with recent lacunar stroke.","volume":"367","author":"Benavente","year":"2012","journal-title":"N Engl J Med"},{"issue":"11","key":"noi260054r6","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1105335","article-title":"Stenting versus aggressive medical therapy for intracranial arterial stenosis.","volume":"365","author":"Chimowitz","year":"2011","journal-title":"N Engl J Med"},{"issue":"9","key":"noi260054r7","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1212\/WNL.39.9.1246","article-title":"Intracranial branch atheromatous disease: a neglected, understudied, and underused concept.","volume":"39","author":"Caplan","year":"1989","journal-title":"Neurology"},{"issue":"9","key":"noi260054r8","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1212\/WNL.21.9.900","article-title":"Basilar artery branch occlusion: a cause of pontine infarction.","volume":"21","author":"Fisher","year":"1971","journal-title":"Neurology"},{"issue":"1","key":"noi260054r9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000341399","article-title":"Branch atheromatous plaque: a major cause of lacunar infarction (high-resolution MRI study).","volume":"2","author":"Chung","year":"2012","journal-title":"Cerebrovasc Dis Extra"},{"issue":"7","key":"noi260054r10","doi-asserted-by":"publisher","first-page":"701","DOI":"10.5551\/jat.RV22003","article-title":"Pathophysiology and optimal treatment of intracranial branch atheromatous disease.","volume":"30","author":"Deguchi","year":"2023","journal-title":"J Atheroscler Thromb"},{"issue":"10","key":"noi260054r11","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1161\/STROKEAHA.124.047688","article-title":"Clinical and prognostic characteristics of acute BAD-related stroke: a multicenter MRI-based prospective study.","volume":"55","author":"Li","year":"2024","journal-title":"Stroke"},{"issue":"1-2","key":"noi260054r12","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jns.2011.01.008","article-title":"Ischemic stroke related to intracranial branch atheromatous disease and comparison with large and small artery diseases.","volume":"303","author":"Kwan","year":"2011","journal-title":"J Neurol Sci"},{"issue":"9","key":"noi260054r13","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1177\/1747493019852177","article-title":"Branch atheromatous disease diagnosed as embolic stroke of undetermined source: a sub-analysis of NAVIGATE ESUS.","volume":"14","author":"Uchiyama","year":"2019","journal-title":"Int J Stroke"},{"issue":"6","key":"noi260054r14","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1001\/jamaneurol.2018.0247","article-title":"Dual antiplatelet therapy in transient ischemic attack and minor stroke with different infarction patterns: subgroup analysis of the CHANCE randomized clinical trial.","volume":"75","author":"Jing","year":"2018","journal-title":"JAMA Neurol"},{"key":"noi260054r15","doi-asserted-by":"publisher","DOI":"10.1177\/17562864251357274","article-title":"Early intensive therapy for preventing neurological deterioration in branch atheromatous disease.","volume":"18","author":"Huang","year":"2025","journal-title":"Ther Adv Neurol Disord"},{"issue":"5","key":"noi260054r16","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520926298","article-title":"Early administration of tirofiban after urokinase-mediated intravenous thrombolysis reduces early neurological deterioration in patients with branch atheromatous disease.","volume":"48","author":"Liu","year":"2020","journal-title":"J Int Med Res"},{"issue":"20","key":"noi260054r17","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.2169\/internalmedicine.1209-22","article-title":"Efficacy of treatment with and without initial clopidogrel loading in branch atheromatous disease.","volume":"62","author":"Deguchi","year":"2023","journal-title":"Intern Med"},{"issue":"3","key":"noi260054r18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000450835","article-title":"Ultra-early combination antiplatelet therapy with cilostazol for the prevention of branch atheromatous disease: a multicenter prospective study.","volume":"6","author":"Kimura","year":"2016","journal-title":"Cerebrovasc Dis Extra"},{"issue":"6","key":"noi260054r19","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.2165\/00003495-199856060-00017","article-title":"Tirofiban: a review of its use in acute coronary syndromes.","volume":"56","author":"McClellan","year":"1998","journal-title":"Drugs"},{"issue":"5","key":"noi260054r20","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s40265-019-01078-0","article-title":"Platelet glycoprotein IIb\/IIIa receptor inhibitor tirofiban in acute ischemic stroke.","volume":"79","author":"Yang","year":"2019","journal-title":"Drugs"},{"issue":"19","key":"noi260054r21","doi-asserted-by":"publisher","first-page":"e1996","DOI":"10.1212\/WNL.0000000000207194","article-title":"Association of tirofiban with functional outcomes after thrombectomy in acute ischemic stroke due to intracranial atherosclerotic disease.","volume":"100","author":"Sang","year":"2023","journal-title":"Neurology"},{"issue":"6","key":"noi260054r22","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1001\/jama.2022.12584","article-title":"Effect of intravenous tirofiban vs placebo before endovascular thrombectomy on functional outcomes in large vessel occlusion stroke: the RESCUE BT randomized clinical trial.","volume":"328","author":"Qiu","year":"2022","journal-title":"JAMA"},{"issue":"4","key":"noi260054r23","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.5308","article-title":"Tirofiban on first-pass recanalization in acute stroke endovascular thrombectomy: the OPTIMISTIC randomized clinical trial.","volume":"8","author":"Lin","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"6","key":"noi260054r24","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1001\/jamaneurol.2024.0868","article-title":"Effects of tirofiban on neurological deterioration in patients with acute ischemic stroke: a randomized clinical trial.","volume":"81","author":"Zhao","year":"2024","journal-title":"JAMA Neurol"},{"issue":"22","key":"noi260054r25","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1056\/NEJMoa2214299","article-title":"Tirofiban for stroke without large or medium-sized vessel occlusion.","volume":"388","author":"Zi","year":"2023","journal-title":"N Engl J Med"},{"issue":"1","key":"noi260054r26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1136\/svn-2022-002284","article-title":"Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY): protocol for a multicentre, randomised controlled trial.","volume":"9","author":"Liao","year":"2024","journal-title":"Stroke Vasc Neurol"},{"issue":"22","key":"noi260054r27","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1001\/jama.2025.4347","article-title":"CONSORT 2025 statement: updated guideline for reporting randomized trials.","volume":"333","author":"Hopewell","year":"2025","journal-title":"JAMA"},{"issue":"2","key":"noi260054r28","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1136\/svn-2020-000378","article-title":"Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases.","volume":"5","author":"Liu","year":"2020","journal-title":"Stroke Vasc Neurol"},{"issue":"10","key":"noi260054r29","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1097\/HJH.0000000000000675","article-title":"Blood pressure variability and the development of early neurological deterioration following acute ischemic stroke.","volume":"33","author":"Chung","year":"2015","journal-title":"J Hypertens"},{"issue":"3","key":"noi260054r30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.07.018","article-title":"Demographic, clinical, and radiologic predictors of neurologic deterioration in patients with acute ischemic stroke.","volume":"22","author":"Miyamoto","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"2","key":"noi260054r31","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1161\/STROKEAHA.125.053320","article-title":"Management strategies for early neurological deterioration in noncardioembolic ischemic stroke.","volume":"57","author":"Kim","year":"2026","journal-title":"Stroke"},{"issue":"26","key":"noi260054r32","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1056\/NEJMoa2309137","article-title":"Dual antiplatelet treatment up to 72 hours after ischemic stroke.","volume":"389","author":"Gao","year":"2023","journal-title":"N Engl J Med"},{"issue":"12","key":"noi260054r33","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1161\/STROKEAHA.110.599464","article-title":"Diversity of single small subcortical infarctions according to infarct location and parent artery disease: analysis of indicators for small vessel disease and atherosclerosis.","volume":"41","author":"Nah","year":"2010","journal-title":"Stroke"},{"issue":"1","key":"noi260054r34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1215340","article-title":"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"issue":"27","key":"noi260054r35","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1056\/NEJMoa2111749","article-title":"Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA.","volume":"385","author":"Wang","year":"2021","journal-title":"N Engl J Med"},{"issue":"3","key":"noi260054r36","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1056\/NEJMoa1800410","article-title":"Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA.","volume":"379","author":"Johnston","year":"2018","journal-title":"N Engl J Med"},{"issue":"13","key":"noi260054r37","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1212\/WNL.0000000000001972","article-title":"Dual antiplatelet therapy in stroke and ICAS: subgroup analysis of CHANCE.","volume":"85","author":"Liu","year":"2015","journal-title":"Neurology"},{"issue":"12","key":"noi260054r38","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1161\/STROKEAHA.120.032239","article-title":"Ticagrelor added to aspirin in acute nonsevere ischemic stroke or transient ischemic attack of atherosclerotic origin.","volume":"51","author":"Amarenco","year":"2020","journal-title":"Stroke"},{"issue":"3","key":"noi260054r39","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/jmri.28839","article-title":"Evaluating middle cerebral artery plaque characteristics and lenticulostriate artery morphology associated with subcortical infarctions at 7T MRI.","volume":"59","author":"Bai","year":"2024","journal-title":"J Magn Reson Imaging"}],"container-title":["JAMA Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/articlepdf\/2853598\/jamaneurology_wang_2026_oi_260054_1790958454.50263.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:00:22Z","timestamp":1791817222000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2853598"}},"subtitle":["The STRATEGY Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaneurol.2026.2855","relation":{},"ISSN":["2168-6149"],"issn-type":[{"value":"2168-6149","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}