{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:15:11Z","timestamp":1790338511771,"version":"4.1.0"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Oncol"],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1001\/jamaoncol.2018.2583","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T07:32:28Z","timestamp":1532071948000},"page":"1751","source":"Crossref","is-referenced-by-count":43,"title":["Association of Transforming Growth Factor \u03b2 Polymorphism C\u2212509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer"],"prefix":"10.1001","volume":"4","author":[{"given":"Aaron J.","family":"Grossberg","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"},{"name":"Department of Radiation Medicine, Oregon Health and Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiudong","family":"Lei","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona F.","family":"Shaitelman","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Stauder","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Welela","family":"Tereffe","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Schlembach","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Woodward","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"coi180053r1","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/S0093-7754(01)90133-2","article-title":"Prevention of invasive breast cancer in women with ductal carcinoma in situ.","volume":"28","author":"Fisher","year":"2001","journal-title":"Semin Oncol"},{"issue":"21","key":"coi180053r2","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1200\/JCO.2006.06.1366","article-title":"Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ.","volume":"24","author":"Bijker","year":"2006","journal-title":"J Clin Oncol"},{"issue":"5","key":"coi180053r3","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1080\/02841860600681569","article-title":"SweDCIS: radiotherapy after sector resection for ductal carcinoma in situ of the breast.","volume":"45","author":"Emdin","year":"2006","journal-title":"Acta Oncol"},{"issue":"9378","key":"coi180053r4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0140-6736(03)13859-7","article-title":"Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand.","volume":"362","author":"Houghton","year":"2003","journal-title":"Lancet"},{"issue":"9503","key":"coi180053r5","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","article-title":"Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival.","volume":"366","author":"Clarke","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"coi180053r6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.radonc.2009.12.007","article-title":"Establishment of a radiogenomics consortium.","volume":"94","author":"West","year":"2010","journal-title":"Radiother Oncol"},{"issue":"24","key":"coi180053r7","first-page":"8717","article-title":"ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.","volume":"63","author":"Ang\u00e8le","year":"2003","journal-title":"Cancer Res"},{"issue":"8","key":"coi180053r8","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1158\/1078-0432.CCR-05-2703","article-title":"Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.","volume":"12","author":"Damaraju","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"3","key":"coi180053r9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ijrobp.2007.04.012","article-title":"Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy.","volume":"69","author":"Ho","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"20","key":"coi180053r10","doi-asserted-by":"publisher","first-page":"6683","DOI":"10.1158\/1078-0432.CCR-07-4389","article-title":"IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.","volume":"14","author":"Isomura","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"1","key":"coi180053r11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.radonc.2004.12.012","article-title":"TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer.","volume":"75","author":"Andreassen","year":"2005","journal-title":"Radiother Oncol"},{"issue":"2","key":"coi180053r12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.radonc.2003.09.010","article-title":"Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes.","volume":"69","author":"Andreassen","year":"2003","journal-title":"Radiother Oncol"},{"issue":"8","key":"coi180053r13","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/09553000600876637","article-title":"Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM.","volume":"82","author":"Andreassen","year":"2006","journal-title":"Int J Radiat Biol"},{"issue":"10","key":"coi180053r14","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1038\/sj.bjc.6605036","article-title":"Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.","volume":"100","author":"Chang-Claude","year":"2009","journal-title":"Br J Cancer"},{"issue":"6","key":"coi180053r15","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/sj.bjc.6603637","article-title":"The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes.","volume":"96","author":"Giotopoulos","year":"2007","journal-title":"Br J Cancer"},{"issue":"2","key":"coi180053r16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/0955300021000045673","article-title":"Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients.","volume":"79","author":"Quarmby","year":"2003","journal-title":"Int J Radiat Biol"},{"issue":"1","key":"coi180053r17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1084\/jem.165.1.251","article-title":"Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.","volume":"165","author":"Postlethwaite","year":"1987","journal-title":"J Exp Med"},{"issue":"7","key":"coi180053r18","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1001\/jama.1989.03430070086036","article-title":"Transforming growth factor\u2013\u00df: multiple actions and potential clinical applications.","volume":"262","author":"Sporn","year":"1989","journal-title":"JAMA"},{"issue":"1","key":"coi180053r19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/hmg\/8.1.93","article-title":"Genetic control of the circulating concentration of transforming growth factor type beta1.","volume":"8","author":"Grainger","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"2","key":"coi180053r20","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ijrobp.2011.06.2012","article-title":"Common variants of GSTP1, GSTA1, and TGF\u00df1 are associated with the risk of radiation-induced fibrosis in breast cancer patients.","volume":"83","author":"Terrazzino","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"coi180053r21","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.ijrobp.2005.09.014","article-title":"ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy.","volume":"64","author":"Andreassen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"coi180053r22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.radonc.2010.01.016","article-title":"Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.","volume":"97","author":"Zschenker","year":"2010","journal-title":"Radiother Oncol"},{"issue":"1","key":"coi180053r23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S1470-2045(11)70302-3","article-title":"Independent validation of genes and polymorphisms reported to be associated with radiation toxicity.","volume":"13","author":"Barnett","year":"2012","journal-title":"Lancet Oncol"},{"issue":"1","key":"coi180053r24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.radonc.2009.12.006","article-title":"No association between SNPs regulating TGF-\u00df1 secretion and late radiotherapy toxicity to the breast.","volume":"97","author":"Barnett","year":"2010","journal-title":"Radiother Oncol"},{"issue":"1","key":"coi180053r25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0167-8140(95)97448-M","article-title":"Late effects toxicity scoring.","volume":"35","author":"Pavy","year":"1995","journal-title":"Radiother Oncol"},{"issue":"4","key":"coi180053r26","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0360-3016(02)04202-5","article-title":"Increasing the rate of late toxicity by changing the score?.","volume":"55","author":"Hoeller","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"coi180053r27","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1001\/jamaoncol.2015.2666","article-title":"Acute and short-term toxic effects of conventionally fractionated vs hypofractionated whole-breast irradiation.","volume":"1","author":"Shaitelman","year":"2015","journal-title":"JAMA Oncol"},{"issue":"12","key":"coi180053r28","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/(ISSN)1097-0142","article-title":"Form or function? part 1: subjective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy.","volume":"91","author":"Stanton","year":"2001","journal-title":"Cancer"},{"issue":"2","key":"coi180053r29","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0959-8049(00)00353-1","article-title":"A body image scale for use with cancer patients.","volume":"37","author":"Hopwood","year":"2001","journal-title":"Eur J Cancer"},{"issue":"3","key":"coi180053r30","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1200\/JCO.1997.15.3.974","article-title":"Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.","volume":"15","author":"Brady","year":"1997","journal-title":"J Clin Oncol"},{"issue":"2","key":"coi180053r31","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0360-3016(79)90729-6","article-title":"Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast.","volume":"5","author":"Harris","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"coi180053r32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","article-title":"Bias reduction of maximum likelihood estimates.","volume":"80","author":"Firth","year":"1993","journal-title":"Biometrika"}],"container-title":["JAMA Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2687973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T17:14:55Z","timestamp":1544721295000},"score":1,"resource":{"primary":{"URL":"http:\/\/oncology.jamanetwork.com\/article.aspx?doi=10.1001\/jamaoncol.2018.2583"}},"subtitle":["A Secondary Analysis of a Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoncol.2018.2583","relation":{},"ISSN":["2374-2437"],"issn-type":[{"value":"2374-2437","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,1]]}}}