{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:32:27Z","timestamp":1790951547731,"version":"4.1.0"},"reference-count":24,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Oncol"],"published-print":{"date-parts":[[2021,11,1]]},"DOI":"10.1001\/jamaoncol.2021.3701","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T15:06:12Z","timestamp":1631804772000},"page":"1664","source":"Crossref","is-referenced-by-count":94,"title":["Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the <i>ATM<\/i> Gene"],"prefix":"10.1001","volume":"7","author":[{"given":"Fang-Chi","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"},{"name":"Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Childs","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari G.","family":"Rabe","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Borgida","sequence":"additional","affiliation":[{"name":"Divison of General Surgery, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinedu","family":"Ukaegbu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Goggins","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"},{"name":"Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland"},{"name":"Division of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H.","family":"Hruban","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"},{"name":"Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Zogopoulos","sequence":"additional","affiliation":[{"name":"The Research Institute of the McGill University Health Centre and the Rosalind and Morris Goodman Cancer Research Centre of McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Syngal","sequence":"additional","affiliation":[{"name":"Population Sciences Division, Dana-Farber Cancer Institute, Boston, Massachusetts"},{"name":"Gastroenterology Division, Brigham and Women's Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Divison of General Surgery, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria M.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison P.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland"},{"name":"Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland"},{"name":"Division of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"coi210057r1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.v71.1","article-title":"Cancer statistics, 2021.","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"coi210057r2","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1093\/jnci\/djaa004","article-title":"Recent trends in the incidence and survival of stage 1a pancreatic cancer: a surveillance, epidemiology, and end results analysis.","volume":"112","author":"Blackford","year":"2020","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"coi210057r3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.6004\/jnccn.2020.0017","article-title":"NCCN Guidelines insights: genetic\/familial high-risk assessment: breast, ovarian, and pancreatic, version 1.2020.","volume":"18","author":"Daly","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"issue":"30","key":"coi210057r4","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.1200\/JCO.2017.72.3502","article-title":"Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma.","volume":"35","author":"Shindo","year":"2017","journal-title":"J Clin Oncol"},{"issue":"1","key":"coi210057r5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s41436-018-0009-5","article-title":"Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.","volume":"21","author":"Yurgelun","year":"2019","journal-title":"Genet Med"},{"issue":"23","key":"coi210057r6","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1001\/jama.2018.6228","article-title":"Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer.","volume":"319","author":"Hu","year":"2018","journal-title":"JAMA"},{"issue":"1","key":"coi210057r7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/nrc3420","article-title":"Identifying people at a high risk of developing pancreatic cancer.","volume":"13","author":"Klein","year":"2013","journal-title":"Nat Rev Cancer"},{"issue":"15","key":"coi210057r8","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1093\/jnci\/91.15.1310","article-title":"Cancer risks in BRCA2 mutation carriers.","volume":"91","author":"Breast Cancer Linkage Consortium","year":"1999","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"coi210057r9","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1158\/1055-9965.EPI-12-0195","article-title":"Risk of pancreatic cancer in breast cancer families from the breast cancer family registry.","volume":"22","author":"Mocci","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"18","key":"coi210057r10","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1093\/jnci\/94.18.1358","article-title":"Cancer incidence in BRCA1 mutation carriers.","volume":"94","author":"Thompson","year":"2002","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"coi210057r11","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1038\/s41379-020-0629-6","article-title":"The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go.","volume":"33","author":"Thompson","year":"2020","journal-title":"Mod Pathol"},{"issue":"1","key":"coi210057r12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1158\/2159-8290.CD-11-0194","article-title":"ATM mutations in patients with hereditary pancreatic cancer.","volume":"2","author":"Roberts","year":"2012","journal-title":"Cancer Discov"},{"issue":"2","key":"coi210057r13","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1158\/2159-8290.CD-15-0402","article-title":"Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer.","volume":"6","author":"Roberts","year":"2016","journal-title":"Cancer Discov"},{"issue":"3","key":"coi210057r14","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/jnci\/djaa095","article-title":"Pathogenic ATM mutations in cancer and a genetic basis for radiotherapeutic efficacy.","volume":"113","author":"Pitter","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"coi210057r15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrm2514","article-title":"Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.","volume":"9","author":"Lavin","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"coi210057r16","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/jnci\/dji141","article-title":"Cancer risks and mortality in heterozygous ATM mutation carriers.","volume":"97","author":"Thompson","year":"2005","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"coi210057r17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1136\/gutjnl-2019-319352","article-title":"Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.","volume":"69","author":"Goggins","year":"2020","journal-title":"Gut"},{"issue":"7","key":"coi210057r18","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/gim.2014.153","article-title":"BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.","volume":"17","author":"Zhen","year":"2015","journal-title":"Genet Med"},{"issue":"3","key":"coi210057r19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1053\/j.gastro.2014.11.042","article-title":"Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.","volume":"148","author":"Grant","year":"2015","journal-title":"Gastroenterology"},{"issue":"12","key":"coi210057r20","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1093\/bioinformatics\/btt187","article-title":"Mendel: the Swiss army knife of genetic analysis programs.","volume":"29","author":"Lange","year":"2013","journal-title":"Bioinformatics"},{"issue":"6","key":"coi210057r22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1159\/000152448","article-title":"A general model for the genetic analysis of pedigree data.","volume":"21","author":"Elston","year":"1971","journal-title":"Hum Hered"},{"issue":"8","key":"coi210057r23","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1073\/pnas.84.8.2363","article-title":"Construction of multilocus genetic linkage maps in humans.","volume":"84","author":"Lander","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"coi210057r24","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1038\/bjc.2012.483","article-title":"The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers.","volume":"107","author":"Iqbal","year":"2012","journal-title":"Br J Cancer"},{"key":"coi210057r21","unstructured":"National Cancer Institute. Surveillance, Epidemiology, and End Results Program, 2000-2017. Accessed August 17, 2021. https:\/\/seer.cancer.gov\/"}],"container-title":["JAMA Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/articlepdf\/2783767\/jamaoncology_hsu_2021_oi_210057_1636656360.56599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T16:48:02Z","timestamp":1637254082000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2783767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoncol.2021.3701","relation":{},"ISSN":["2374-2437"],"issn-type":[{"value":"2374-2437","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,1]]}}}