{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:38:39Z","timestamp":1787168319070,"version":"build-2736575974"},"reference-count":49,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Oncol"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"\n Importance<\/jats:title>\n Prior studies, largely among middle-aged adults, reported aspirin reduces cancer risk after 10 years, particularly for colorectal cancer (CRC). In contrast, the Aspirin in Reducing Events in the Elderly (ASPREE) randomized clinical trial (RCT) reported that low-dose aspirin (LDA) treatment for a median of 4.7 years had no effect on overall cancer incidence but increased risk of incident late-stage cancer and cancer-related mortality.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess whether LDA is associated with cancer incidence and mortality in 10 years of follow-up in older adults (aged \u226570 years) and to assess the association with cancer after prior LDA exposure (legacy effects).<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This community-based binational (Australian and US) cohort study included community-dwelling older adults (aged \u226570 years for Australian participants and \u226565 years for US minority group participants) free from overt cardiovascular disease, dementia, or independence-limiting physical disability. The cohort was derived from the ASPREE randomized clinical trial conducted from 2010 to 2017, with the observational extension study (ASPREE-XT) following up participants from 2018 to 2024. This study reports data from 2010 through 2022 (long-term outcomes) as well as reports analyses confined to the observation phase only (legacy analyses). Data were analyzed from May to November 2025.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Daily 100-mg aspirin or placebo from randomization until cessation of study drug.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Outcomes were physician-adjudicated incident cancer, type, stage at diagnosis, and cancer mortality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In 19\u202f114 community-dwelling older adults (mean [SD] age, 75.1 [4.5] years; 56.4% female), a total of 3448 incident cancers and 1173 cancer-related deaths occurred over 10 years of follow-up (median, 8.6 [IQR, 7.4-10.0] years) during ASPREE and ASPREE-XT. LDA was not associated with overall cancer incidence over the long term (hazard ratio [HR]\u2009=\u20090.98; 95% CI, 0.92-1.05), by stage at diagnosis or cancer type, including colorectal cancer (HR\u2009=\u20091.01; 95% CI, 0.84-1.21). However, LDA was associated with increased cancer-related mortality (HR\u2009=\u20091.15; 95% CI, 1.03-1.29). Among 14\u202f907 participants without cancer during the RCT and consented into ASPREE-XT (median age, 78.6 years [IQR, 76.2-82.1]; 57.5% female), 1451 incident cancers and 376 cancer deaths occurred in the post-RCT period, during which original aspirin assignment during the RCT was not associated with differences in cancer incidence (HR\u2009=\u20090.91; 95% CI, 0.82-1.01) or cancer-related mortality (HR\u2009=\u20091.02; 95% CI, 0.83-1.25) compared with original placebo assignment.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this study, over a median of 8.6 years, LDA was not associated with incident cancer among older adults, but cancer mortality risk was significantly elevated. However, the elevated cancer mortality risk seen with aspirin for participants in the RCT period did not persist into the post-RCT observation period, suggesting no legacy effect.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaoncol.2025.6196","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:30:21Z","timestamp":1769704221000},"page":"285","source":"Crossref","is-referenced-by-count":4,"title":["Cancer Incidence and Mortality With Aspirin in Older Adults"],"prefix":"10.1001","volume":"12","author":[{"given":"Suzanne G.","family":"Orchard","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Polekhina","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Zalcberg","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Uniformed Services University of Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay","family":"Macrae","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Tie","sequence":"additional","affiliation":[{"name":"Personalised Oncology Division, Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Medical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Gately","sequence":"additional","affiliation":[{"name":"Personalised Oncology Division, Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Medical Oncology, Alfred Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mar","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Millar","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"},{"name":"Department of Radiation Oncology, Alfred Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Maria","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Division of Cancer Prevention, Bethesda, Maryland"},{"name":"Department of Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"van Londen","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Alfred Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Hiscutt","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"},{"name":"Victorian Melanoma Service, Alfred Health, Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Loon","family":"Ong","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"},{"name":"Department of Radiation Oncology, Alfred Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica T.","family":"Warner","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Ford","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Division of Cancer Prevention, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Umar","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Division of Cancer Prevention, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McNeil","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nelson","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Stocks","sequence":"additional","affiliation":[{"name":"Discipline of General Practice, University of Adelaide, Adelaide SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj C.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Family & Preventive Medicine and the Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Kirpach","sequence":"additional","affiliation":[{"name":"Berman Centre for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Division of Geriatrics, Department of Medicine Hennepin HealthCare, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Murray","sequence":"additional","affiliation":[{"name":"Berman Centre for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Division of Geriatrics, Department of Medicine Hennepin HealthCare, Minneapolis, Minnesota"},{"name":"University of Minnesota, Minneapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"Woods","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Personalised Oncology Division, Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Medical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"3","key":"coi250084r1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"coi250084r2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1093\/geront\/gnz038","article-title":"Cancer Risk Among Older Adults: Time for Cancer Prevention to Go Silver.","volume":"59","author":"White","year":"2019","journal-title":"Gerontologist"},{"issue":"9826","key":"coi250084r3","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","article-title":"Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials.","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"coi250084r4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.7326\/0003-4819-159-2-201307160-00002","article-title":"Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial.","volume":"159","author":"Cook","year":"2013","journal-title":"Ann Intern Med"},{"issue":"16","key":"coi250084r5","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1056\/NEJMoa1804988","article-title":"Effects of aspirin for primary prevention in persons with diabetes mellitus.","volume":"379","author":"Bowman","year":"2018","journal-title":"N Engl J Med"},{"issue":"21","key":"coi250084r6","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.7150\/jca.49001","article-title":"Long-term aspirin use for primary cancer prevention: An updated systematic review and subgroup meta-analysis of 29 randomized clinical trials.","volume":"11","author":"Wu","year":"2020","journal-title":"J Cancer"},{"issue":"10152","key":"coi250084r7","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/S0140-6736(18)31924-X","article-title":"Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial.","volume":"392","author":"Gaziano","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"coi250084r8","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/jnci\/djaa114","article-title":"Effect of aspirin on cancer incidence and mortality in older adults.","volume":"113","author":"McNeil","year":"2021","journal-title":"J Natl Cancer Inst"},{"key":"coi250084r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.106095","article-title":"Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial.","volume":"96","author":"Orchard","year":"2020","journal-title":"Contemp Clin Trials"},{"issue":"11","key":"coi250084r10","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/gerona\/glw342","article-title":"Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study.","volume":"72","author":"McNeil","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"coi250084r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2023.107231","article-title":"Health characteristics and aspirin use in participants at the baseline of the ASPirin in Reducing Events in the Elderly - eXTension (ASPREE-XT) Observational Study.","volume":"130","author":"Ernst","year":"2023","journal-title":"Contemp Clin Trials"},{"issue":"2","key":"coi250084r14","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cct.2013.09.014","article-title":"Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial.","volume":"36","author":"ASPREE Investigator Group","year":"2013","journal-title":"Contemp Clin Trials"},{"key":"coi250084r15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/bs.acr.2021.02.007","article-title":"Racial and ethnic disparities in colorectal cancer incidence and mortality.","volume":"151","author":"Carethers","year":"2021","journal-title":"Adv Cancer Res"},{"issue":"8","key":"coi250084r16","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2337\/dc18-0368","article-title":"Effect of aspirin on cancer chemoprevention in Japanese patients with type 2 diabetes: 10-year observational follow-up of a randomized controlled trial.","volume":"41","author":"Okada","year":"2018","journal-title":"Diabetes Care"},{"issue":"9759","key":"coi250084r17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(10)62110-1","article-title":"Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.","volume":"377","author":"Rothwell","year":"2011","journal-title":"Lancet"},{"key":"coi250084r18","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.3332\/ecancer.2021.1258","article-title":"Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers.","volume":"15","author":"Elwood","year":"2021","journal-title":"Ecancermedicalscience"},{"key":"coi250084r19","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.690219","article-title":"Aspirin use and common cancer risk: a meta-analysis of cohort studies and randomized controlled trials.","volume":"11","author":"Wang","year":"2021","journal-title":"Front Oncol"},{"issue":"12","key":"coi250084r20","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1002\/ijc.35331","article-title":"Long-term use of low-dose aspirin for cancer prevention: A 20-year longitudinal cohort study of 1,506,525 Hong Kong residents.","volume":"156","author":"Lam","year":"2025","journal-title":"Int J Cancer"},{"issue":"3","key":"coi250084r21","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1053\/j.gastro.2013.11.005","article-title":"Low-dose aspirin use after diagnosis of colorectal cancer does not increase survival: a case-control analysis of a population-based cohort.","volume":"146","author":"Cardwell","year":"2014","journal-title":"Gastroenterology"},{"issue":"4","key":"coi250084r22","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/jnci\/djad231","article-title":"Long-term aspirin use and cancer risk: a 20-year cohort study.","volume":"116","author":"Skriver","year":"2024","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"coi250084r23","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1001\/jamaoncol.2020.7338","article-title":"Aspirin Use and Risk of Colorectal Cancer Among Older Adults.","volume":"7","author":"Guo","year":"2021","journal-title":"JAMA Oncol"},{"key":"coi250084r24","article-title":"Role of aspirin in cancer prevention.","volume":"43","author":"Sun","year":"2025","journal-title":"Cancer Treat Res Commun"},{"issue":"8060","key":"coi250084r25","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/s41586-025-08626-7","article-title":"Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity.","volume":"640","author":"Yang","year":"2025","journal-title":"Nature"},{"key":"coi250084r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2025.110486","article-title":"T cell aging and exhaustion: Mechanisms and clinical implications.","volume":"275","author":"Zhang","year":"2025","journal-title":"Clin Immunol"},{"issue":"10","key":"coi250084r27","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1001\/jamaoncol.2022.2967","article-title":"Aspirin and the USPSTF-what about cancer?","volume":"8","author":"Chan","year":"2022","journal-title":"JAMA Oncol"},{"key":"coi250084r28","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1146\/annurev-med-060319-120913","article-title":"Aspirin in the prevention of colorectal neoplasia.","volume":"72","author":"Drew","year":"2021","journal-title":"Annu Rev Med"},{"issue":"1","key":"coi250084r29","doi-asserted-by":"publisher","first-page":"3722","DOI":"10.1038\/s41467-019-11530-0","article-title":"Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients.","volume":"10","author":"Serebriiskii","year":"2019","journal-title":"Nat Commun"},{"issue":"7","key":"coi250084r30","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1002\/cam4.1544","article-title":"Molecular features in young vs elderly breast cancer patients and the impacts on survival disparities by age at diagnosis.","volume":"7","author":"Wang","year":"2018","journal-title":"Cancer Med"},{"issue":"1","key":"coi250084r31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/DCR.0b013e3181bc01d1","article-title":"Evaluating the age distribution of patients with colorectal cancer: are the United States Preventative Services Task Force guidelines for colorectal cancer screening appropriate?","volume":"53","author":"Shellnut","year":"2010","journal-title":"Dis Colon Rectum"},{"issue":"4","key":"coi250084r32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jgo.2014.08.002","article-title":"High prevalence of deficient mismatch repair phenotype and the V600E BRAF mutation in elderly patients with colorectal cancer.","volume":"5","author":"Aparicio","year":"2014","journal-title":"J Geriatr Oncol"},{"issue":"2","key":"coi250084r33","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/carcin\/bgt391","article-title":"Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer.","volume":"35","author":"Xu","year":"2014","journal-title":"Carcinogenesis"},{"issue":"11","key":"coi250084r34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078093","article-title":"The association of four common polymorphisms from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity: a meta-analysis.","volume":"8","author":"Weng","year":"2013","journal-title":"PLoS One"},{"issue":"10240","key":"coi250084r35","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/S0140-6736(20)30366-4","article-title":"Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial.","volume":"395","author":"Burn","year":"2020","journal-title":"Lancet"},{"issue":"9754","key":"coi250084r36","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(10)61543-7","article-title":"Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials.","volume":"376","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"issue":"5","key":"coi250084r37","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.annonc.2020.02.012","article-title":"Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019.","volume":"31","author":"Bosetti","year":"2020","journal-title":"Ann Oncol"},{"issue":"16","key":"coi250084r38","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1001\/jama.2022.3337","article-title":"Aspirin use to prevent cardiovascular disease and colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force.","volume":"327","author":"Guirguis-Blake","year":"2022","journal-title":"JAMA"},{"key":"coi250084r39","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1505904","article-title":"Ultraviolet and infrared radiation in Australia: assessing the benefits, risks, and optimal exposure guidelines.","volume":"12","author":"Sharma","year":"2024","journal-title":"Front Public Health"},{"issue":"8","key":"coi250084r40","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1002\/cncr.27817","article-title":"Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women\u2019s Health Initiative.","volume":"119","author":"Gamba","year":"2013","journal-title":"Cancer"},{"issue":"7","key":"coi250084r41","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1038\/jid.2011.58","article-title":"Long-term use of nonsteroidal anti-inflammatory drugs decreases the risk of cutaneous melanoma: results of a United States case-control study.","volume":"131","author":"Curiel-Lewandrowski","year":"2011","journal-title":"J Invest Dermatol"},{"issue":"11","key":"coi250084r42","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1038\/jid.2009.201","article-title":"Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study.","volume":"129","author":"Joosse","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"7","key":"coi250084r43","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00403-024-03056-3","article-title":"Aspirin as a chemopreventive agent for cutaneous melanoma: a literature review.","volume":"316","author":"Pulumati","year":"2024","journal-title":"Arch Dermatol Res"},{"issue":"1","key":"coi250084r44","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/CEJ.0b013e328360f479","article-title":"Nonsteroidal anti-inflammatory drug use and the risk of melanoma: a meta-analysis.","volume":"23","author":"Hu","year":"2014","journal-title":"Eur J Cancer Prev"},{"key":"coi250084r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104499","article-title":"The association between nonsteroidal anti-inflammatory drugs and skin cancer: different responses in American and European populations.","volume":"152","author":"Ma","year":"2020","journal-title":"Pharmacol Res"},{"issue":"11","key":"coi250084r46","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1158\/1940-6207.CAPR-22-0229","article-title":"Use of nonsteroidal anti-inflammatory drugs and incidence of melanoma in the United States Radiologic Technologists study.","volume":"15","author":"Mai","year":"2022","journal-title":"Cancer Prev Res (Phila)"},{"issue":"9","key":"coi250084r47","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s10552-012-0019-6","article-title":"Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses\u2019 Health Study.","volume":"23","author":"Jeter","year":"2012","journal-title":"Cancer Causes Control"},{"issue":"4","key":"coi250084r48","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.jaad.2018.03.031","article-title":"Malignant melanoma associated with chronic once-daily aspirin exposure in males: a large, single-center, urban, US patient population cohort study from the \u201cResearch on Adverse Drug events And Report\u201d (RADAR) project.","volume":"79","author":"Orrell","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"42","key":"coi250084r49","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.1093\/eurheartj\/ehaf514","article-title":"Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial.","volume":"46","author":"Wolfe","year":"2025","journal-title":"Eur Heart J"},{"key":"coi250084r12","unstructured":"Aspirin in Reducing Events in the Elderly. Welcome to the ASPREE project. 2024. Accessed December 22, 2025. https:\/\/aspree.org\/"},{"key":"coi250084r13","doi-asserted-by":"crossref","unstructured":"Wolfe? R, Broder? J, Chan? A, . Expanded statistical analysis plan for legacy and long-term effects of aspirin in the ASPREE-XT observational follow-up study of participants in the ASPREE randomized trial.? medRxiv. Preprint posted online September 14, 2023. doi:10.1101\/2023.09.13.23295514","DOI":"10.1101\/2023.09.13.23295514"}],"container-title":["JAMA Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/articlepdf\/2844193\/jamaoncology_orchard_2026_oi_250084_1773666436.43903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:00:19Z","timestamp":1773932419000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2844193"}},"subtitle":["Follow-Up of the ASPREE Trial"],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoncol.2025.6196","relation":{},"ISSN":["2374-2437"],"issn-type":[{"value":"2374-2437","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,1]]}}}