{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:27:25Z","timestamp":1780086445992,"version":"3.54.0"},"reference-count":30,"publisher":"American Medical Association (AMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Oncol"],"abstract":"\n Importance<\/jats:title>\n It remains uncertain which Epstein-Barr virus (EBV)\u2013related\n biomarkers provide the most reliable diagnostic performance for\n suspected nasopharyngeal carcinoma (NPC) in outpatient settings,\n especially regarding the novel anti-EBV BNLF2b total antibody (P85-Ab)\n assay. Clarifying their accuracy is critical to improving early\n detection and reducing misdiagnosis.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the diagnostic performance of the P85-Ab assay in\n suspected NPC in outpatient settings and compare it head-to-head with\n EBV viral capsid antigen (VCA)-immunoglobulin A (IgA), EBV early antigen\n (EA)-IgA, and EBV nuclear antigen 1 (EBNA1)-IgA.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n A prospective, multicenter cohort study was conducted between April\n 2021 and March 2024, with a median follow-up of 27.2 months in\n outpatient clinics across 5 medical centers in China. Key inclusion\n criteria comprised clinically suspected NPC. Data were analyzed from\n June 2025 to July 2025.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n P85-Ab was tested using chemiluminescent immunoassay. VCA-IgA,\n EA-IgA, and EBNA1-IgA were tested via enzyme-linked immunosorbent\n assays.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measure<\/jats:title>\n Primary outcomes included sensitivity and specificity of\n P85-Ab.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 3795 eligible participants were consecutively recruited.\n After excluding individuals with low-quality samples or lost to\n follow-up, 3777 participants were included in the final analysis (1680\n with NPC and 2097 without NPC). Among the 3777 evaluated participants\n (median [IQR] age, 49.0 [37.0-58.0] years; 65 % male), P85-Ab\n demonstrated superior diagnostic performance, with a sensitivity of\n 93.0% (95% CI, 91.6-94.0) and specificity of 97.3% (95% CI, 96.5-97.9).\n Other biomarkers showed lower sensitivity (ranging from 60.4% to 93.0%)\n and specificity (&amp;lt;90%). P85-Ab maintained high sensitivity\n among asymptomatic individuals (92.0%; 95% CI, 85.9-95.6) and those\n presenting with NPC-nonspecific symptoms (88.4%; 95% CI, 75.5-94.9),\n with no additional diagnostic benefit observed from the triplet-antibody\n strategy combining P85-Ab, VCA-IgA, and EBNA1-IgA. However, among\n participants with NPC-specific symptoms, the triplet-antibody strategy\n improved sensitivity compared with P85-Ab alone (95.9%; 95% CI,\n 94.8-96.8 vs 93.1%; 95% CI, 91.7-94.3;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study, P85-Ab was a robust and accurate biomarker for\n suspected NPC in outpatient settings. P85-Ab alone may be suggested for\n populations with asymptomatic or NPC-nonspecific symptoms, and combining\n P85-Ab with VCA-IgA and EBNA1-IgA may be suggested for populations with\n NPC-specific symptoms.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaoncol.2026.0251","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:56:36Z","timestamp":1775159796000},"source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Performance of Anti\u2013Epstein-Barr Virus BNLF2b in Suspected\n Nasopharyngeal Carcinoma"],"prefix":"10.1001","author":[{"given":"Su-Chen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Gui","family":"Li","sequence":"additional","affiliation":[{"name":"The Cancer Research Institute of Zhongshan City, Zhongshan City\n People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ji","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital of Tongji\n Medical College of Huazhong University of Science and Technology, Wuhan,\n Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Nasopharyngeal Carcinoma Molecular\n Epidemiology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhou","family":"Xiao","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology Research,\n Department of Clinical Laboratory, Clinical Oncology School of Fujian\n Medical University, Fujian Cancer Hospital, Fuzhou, Fujian,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Dong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang\n An Biomedicine Laboratory, School of Public Health and National\n Institute of Diagnostics and Vaccine Development in Infectious Diseases,\n State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,\n National Innovation Platform for Industry-Education Integration in\n Vaccine Research, NMPA Key Laboratory for Research and Evaluation of\n Infectious Disease Diagnostic Technology, the Research Unit of Frontier\n Technology of Structural Vaccinology of Chinese Academy of Medical\n Sciences, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning-Shao","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang\n An Biomedicine Laboratory, School of Public Health and National\n Institute of Diagnostics and Vaccine Development in Infectious Diseases,\n State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,\n National Innovation Platform for Industry-Education Integration in\n Vaccine Research, NMPA Key Laboratory for Research and Evaluation of\n Infectious Disease Diagnostic Technology, the Research Unit of Frontier\n Technology of Structural Vaccinology of Chinese Academy of Medical\n Sciences, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Qiang","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Fang","family":"Ji","sequence":"additional","affiliation":[{"name":"The Cancer Research Institute of Zhongshan City, Zhongshan City\n People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Quan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"P85-Ab\n Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yu","sequence":"additional","affiliation":[{"name":"The Cancer Research Institute of Zhongshan City, Zhongshan City\n People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital of Tongji\n Medical College of Huazhong University of Science and Technology, Wuhan,\n Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology Research,\n Department of Clinical Laboratory, Clinical Oncology School of Fujian\n Medical University, Fujian Cancer Hospital, Fuzhou, Fujian,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Collaborative Innovation Centre for Cancer Medicine, Guangdong Key\n Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou,\n Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao-Hua","family":"Wu","sequence":"additional","affiliation":[{"name":"The Cancer Research Institute of Zhongshan City, Zhongshan City\n People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Collaborative Innovation Centre for Cancer Medicine, Guangdong Key\n Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou,\n Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Song","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology Research,\n Department of Clinical Laboratory, Clinical Oncology School of Fujian\n Medical University, Fujian Cancer Hospital, Fuzhou, Fujian,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Xian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Collaborative Innovation Centre for Cancer Medicine, Guangdong Key\n Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou,\n Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Fang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Zhongshan\n City People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Zhongshan\n City People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Zhongshan\n City People\u2019s Hospital, Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xian","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tongji Hospital of Tongji Medical\n College of Huazhong University of Science and Technology, Wuhan, Hubei,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Hospital of Tongji Medical\n College of Huazhong University of Science and Technology, Wuhan, Hubei,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Tongji\n Hospital of Tongji Medical College of Huazhong University of Science and\n Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Sheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wuzhou Red Cross Hospital, Wuzhou,\n Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Bin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Wuzhou Red\n Cross Hospital, Wuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Wuzhou Red Cross Hospital,\n Wuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Juan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Clinical Oncology School of\n Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat-sen University Cancer\n Centre, State Key Laboratory of Oncology in South China, Collaborative\n Innovation Centre for Cancer Medicine, Guangdong Key Laboratory of\n Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Zhongshan City People\u2019s Hospital,\n Zhongshan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wuzhou Red Cross Hospital, Wuzhou,\n Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Oncology School of Fujian\n Medical University, Fujian Cancer Hospital, Fuzhou, Fujian,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer\n Centre, State Key Laboratory of Oncology in South China, Collaborative\n Innovation Centre for Cancer Medicine, Guangzhou, Guangdong,\n China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Collaborative Innovation Centre for Cancer Medicine, Guangzhou,\n Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Collaborative Innovation Centre for Cancer Medicine, Guangzhou,\n Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xiong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Song","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat-sen University\n Cancer Centre, State Key Laboratory of Oncology in South China,\n Guangzhou, China"},{"name":"Collaborative Innovation Centre for Cancer Medicine, Guangdong\n Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,\n Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Xiang","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang\n An Biomedicine Laboratory, School of Public Health and National\n Institute of Diagnostics and Vaccine Development in Infectious Diseases,\n State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,\n National Innovation Platform for Industry-Education Integration in\n Vaccine Research, NMPA Key Laboratory for Research and Evaluation of\n Infectious Disease Diagnostic Technology, the Research Unit of Frontier\n Technology of Structural Vaccinology of Chinese Academy of Medical\n Sciences, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang\n An Biomedicine Laboratory, School of Public Health and National\n Institute of Diagnostics and Vaccine Development in Infectious Diseases,\n State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,\n National Innovation Platform for Industry-Education Integration in\n Vaccine Research, NMPA Key Laboratory for Research and Evaluation of\n Infectious Disease Diagnostic Technology, the Research Unit of Frontier\n Technology of Structural Vaccinology of Chinese Academy of Medical\n Sciences, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"issue":"10192","key":"coi260005r1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal 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