{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:30:17Z","timestamp":1792726217320,"version":"4.5.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Oncol"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"\n Importance<\/jats:title>\n Chordoma is a rare malignant bone tumor with high local recurrence, metastatic spread in 40% to 60% of patients over the disease course, and significant morbidity. Because of its rarity, anatomical complexity, and prolonged natural history, high-quality evidence to guide management is limited. International consensus guidelines for localized chordoma were first published in 2015; however, advances in pathology, imaging, surgery, radiotherapy, and supportive care since then necessitate updated multidisciplinary recommendations.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To update and expand the 2015 consensus recommendations on the diagnosis, treatment, and follow-up of pediatric and adult patients with primary, localized chordoma.<\/jats:p>\n <\/jats:sec>\n \n Evidence Review<\/jats:title>\n In June 2025, a meeting of the Global Chordoma Consensus Group was held in Milan, Italy, that included experts from all relevant specialties as well as patient representatives. A comprehensive literature review guided structured discussions on the management of primary localized disease. Levels of evidence and grades of recommendation were assigned.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n A total of 305 articles were included in the literature review. Management strategies were stratified by anatomical site (skull base, mobile spine, and sacrum). The central principal of care was treatment at experienced, multidisciplinary centers, with maximally safe surgery followed by high-dose, highly conformal radiotherapy. Guidance was provided on diagnosis, surgical approaches, and radiotherapy planning for each anatomical site. Systemic therapy options; long-term, risk-adapted follow-up; and supportive, palliative, and rehabilitative care were also addressed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n This global consensus statement provided updated multidisciplinary guidance for the management of primary, localized chordoma. It aimed to harmonize clinical practice, support shared decision-making, and identify priorities for future collaborative research in this rare and challenging disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaoncol.2026.2054","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:00:19Z","timestamp":1783609219000},"page":"1018","source":"Crossref","is-referenced-by-count":3,"title":["Global Consensus on the Management of Primary Localized Chordoma"],"prefix":"10.1001","volume":"12","author":[{"given":"Stefano","family":"Radaelli","sequence":"first","affiliation":[{"name":"Sarcoma Service, Department of Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Frezza","sequence":"additional","affiliation":[{"name":"Adult Mesenchymal and Rare Tumours Unit, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Fossati","sequence":"additional","affiliation":[{"name":"MedAustron Ion Therapy Center, Wiener Neustadt, Austria"},{"name":"Division of Radiation Oncology, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo G.","family":"Baldi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Asencio","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Bolle","sequence":"additional","affiliation":[{"name":"Centro de Proton Terapia Quironsalud, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith V. 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