{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:11:12Z","timestamp":1789053072503,"version":"build-2803163510"},"reference-count":8,"publisher":"American Medical Association (AMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Oncol"],"abstract":"\n Importance<\/jats:title>\n In the KEYNOTE-826 study, pembrolizumab (vs placebo) plus platinum-based chemotherapy (with or without bevacizumab) significantly improved progression-free survival and overall survival in participants with previously untreated persistent, recurrent, or metastatic cervical cancer at interim analysis 1 (median follow-up, 22.0 months), with continued benefit at final analysis (median follow-up, 39.1 months). Long-term follow-up is important to further inform the benefit-risk profile of anticancer treatments.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate 5-year efficacy and safety results of pembrolizumab plus chemotherapy (with or without bevacizumab) in previously untreated persistent, recurrent, or metastatic cervical cancer.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This ad hoc exploratory analysis of the phase 3, double-blind KEYNOTE-826 randomized clinical trial was conducted in participants with previously untreated persistent, recurrent, or metastatic cervical cancer across 151 sites in 19 countries. Participants were randomly assigned to treatment between November 20, 2018, and January 31, 2020. The median follow-up for this analysis was 59.1 (range, 52.1-66.5) months (approximately 20 months after final analysis). Data were analyzed between November 20, 2018, and June 4, 2024.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Pembrolizumab, 200 mg, every 3 weeks for up to 35 cycles vs placebo, each combined with platinum-based chemotherapy (with or without bevacizumab).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Progression-free survival and overall survival.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 617 female patients were randomized. At baseline, the median age of participants was 51.0 (range, 22-82) years, with 303 participants (49.1%) having stage I\/II and 190 (30.8%) having IVB disease and 446 (72.3%) having squamous cell\/squamous cell carcinoma. At 5 years, the overall survival benefit was sustained with pembrolizumab plus chemotherapy in the programmed cell death ligand 1 combined positive score of at least 1 (median [IQR], 28.6 [12.3 to not reached] vs 16.5 [9.0-40.5] months; hazard ratio [HR], 0.62 [95% CI, 0.50-0.76]) and intention-to-treat (median [IQR], 26.4 [12.0 to not reached] vs 16.8 [9.1-40.1] months; HR, 0.64 [95% CI, 0.53-0.78]) populations. The progression-free survival advantage was similarly maintained (median [IQR], 10.5 [6.2 to not reached] vs 8.2 [4.2-17.1] months; HR, 0.58 [95% CI, 0.48-0.71] and median [IQR], 10.4 [6.2 to not reached] vs 8.2 [4.3-15.5] months; HR, 0.61 [95% CI, 0.51-0.74], respectively). No new safety signals were observed. No additional deaths due to treatment-related adverse events had occurred since the final analysis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this exploratory analysis of the KEYNOTE-826 randomized clinical trial, the 5-year data confirm the durability of benefit and reinforce pembrolizumab plus chemotherapy (with or without bevacizumab) as a first-line standard-of-care option for recurrent and metastatic cervical cancer.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT03635567<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaoncol.2026.3547","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:00:19Z","timestamp":1789052419000},"source":"Crossref","is-referenced-by-count":0,"title":["Pembrolizumab Plus Chemotherapy for Cervical Cancer"],"prefix":"10.1001","author":[{"given":"Kosei","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Colombo","sequence":"additional","affiliation":[{"name":"European Institute of Oncology, IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnansu S.","family":"Tewari","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Orange"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coraline","family":"Dubot","sequence":"additional","affiliation":[{"name":"Institut Curie Saint Cloud, Paris, France"},{"name":"GINECO, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Valeria","family":"C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Instituto de Oncolog\u00eda \u00c1ngel H. Roffo, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Shapira-Frommer","sequence":"additional","affiliation":[{"name":"The Ella Institute for Immuno-Oncology, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Salman","sequence":"additional","affiliation":[{"name":"Oncovida Cancer Center, Providencia and Centro de Medicina de Precisi\u00f3n, Universidad Mayor, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ya\u00f1ez","sequence":"additional","affiliation":[{"name":"Universidad de la Frontera, Temuco, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"G\u00fcm\u00fc\u015f","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University Prof Dr Suleyman Yalcin City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mivael Olivera Hurtado","family":"de Mendoza","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Neopl\u00e1sicas, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Samou\u00eblian","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Centre de Recherche de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Castonguay","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Arkhipov","sequence":"additional","affiliation":[{"name":"Medical Rehabilitation Center Under the Ministry of Health of the Russian Federation, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cumhur","family":"Tekin","sequence":"additional","affiliation":[{"name":"Merck & Co, Inc, Rahway, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Jensen","sequence":"additional","affiliation":[{"name":"Merck & Co, Inc, Rahway, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarper","family":"Toker","sequence":"additional","affiliation":[{"name":"Merck & Co, Inc, Rahway, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Monk","sequence":"additional","affiliation":[{"name":"Florida Cancer Specialists and Research Institute, West Palm Beach"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"issue":"20","key":"coi260052r1","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1056\/NEJMoa2112435","article-title":"Pembrolizumab for persistent, recurrent, or metastatic cervical cancer.","volume":"385","author":"Colombo","year":"2021","journal-title":"N Engl J Med"},{"issue":"36","key":"coi260052r2","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.1200\/JCO.23.00914","article-title":"First-line pembrolizumab + chemotherapy versus placebo + chemotherapy for persistent, recurrent, or metastatic cervical cancer: final overall survival results of KEYNOTE-826.","volume":"41","author":"Monk","year":"2023","journal-title":"J Clin Oncol"},{"issue":"5","key":"coi260052r3","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1136\/ijgc-2023-004429","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with cervical cancer \u2014 update 2023.","volume":"33","author":"Cibula","year":"2023","journal-title":"Int J Gynecol Cancer"},{"issue":"3","key":"coi260052r5","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.2668","article-title":"Late-onset immune-related adverse events after immune checkpoint inhibitor therapy.","volume":"8","author":"Durbin","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"8","key":"coi260052r6","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41571-023-00776-9","article-title":"Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship.","volume":"20","author":"Lustberg","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"coi260052r7","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006278","article-title":"Cardiovascular adverse events in patients with cancer treated with bevacizumab: a meta-analysis of more than 20?000 patients.","volume":"6","author":"Totzeck","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"10103","key":"coi260052r8","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1016\/S0140-6736(17)31607-0","article-title":"Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240).","volume":"390","author":"Tewari","year":"2017","journal-title":"Lancet"},{"key":"coi260052r4","unstructured":"National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Cervical cancer. Version 2.2026. Accessed March 4, 2026. https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1426"}],"container-title":["JAMA Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/articlepdf\/2853978\/jamaoncology_hasegawa_2026_oi_260052_1788536114.93303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:00:22Z","timestamp":1789052422000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2853978"}},"subtitle":["An Exploratory Analysis of the KEYNOTE-826 Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":8,"URL":"https:\/\/doi.org\/10.1001\/jamaoncol.2026.3547","relation":{},"ISSN":["2374-2437"],"issn-type":[{"value":"2374-2437","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}