{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:40:59Z","timestamp":1787866859532,"version":"build-2784847793"},"reference-count":31,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1001\/jamaoto.2018.0667","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T16:38:23Z","timestamp":1528389503000},"page":"605","source":"Crossref","is-referenced-by-count":75,"title":["Effect of Budesonide Added to Large-Volume, Low-pressure Saline Sinus Irrigation for Chronic Rhinosinusitis"],"prefix":"10.1001","volume":"144","author":[{"given":"Sarah","family":"Tait","sequence":"first","affiliation":[{"name":"Clinical Outcomes Research Office, Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Clinical Outcomes Research Office, Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Suko","sequence":"additional","affiliation":[{"name":"Clinical Outcomes Research Office, Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kukuljan","sequence":"additional","affiliation":[{"name":"Clinical Outcomes Research Office, Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Schneider","sequence":"additional","affiliation":[{"name":"Clinical Outcomes Research Office, Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay F.","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Clinical Outcomes Research Office, Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"ooi180033r1","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis.","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3 Pt 1","key":"ooi180033r2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0091-6749(99)70464-1","article-title":"Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders.","volume":"103","author":"Ray","year":"1999","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"ooi180033r3","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/lary.22034","article-title":"Incremental healthcare utilization and expenditures for allergic rhinitis in the United States.","volume":"121","author":"Bhattacharyya","year":"2011","journal-title":"Laryngoscope"},{"issue":"4","key":"ooi180033r4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11882-016-0607-8","article-title":"Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter.","volume":"16","author":"Dass","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"ooi180033r5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino50E2","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists.","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"issue":"1","key":"ooi180033r6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jac\/dkt301","article-title":"Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09.","volume":"69","author":"Shapiro","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"17","key":"ooi180033r7","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1001\/jama.2016.4151","article-title":"Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.","volume":"315","author":"Fleming-Dutra","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"ooi180033r8","first-page":"3","article-title":"Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research.","volume":"45","author":"Harvey","year":"2007","journal-title":"Rhinology"},{"issue":"6","key":"ooi180033r9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.otohns.2009.08.006","article-title":"Topical steroids in chronic rhinosinusitis without polyps: a systematic review and meta-analysis.","volume":"141","author":"Kalish","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"8","key":"ooi180033r10","first-page":"CD009274","article-title":"Topical steroid for chronic rhinosinusitis without polyps.","author":"Snidvongs","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"ooi180033r11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/alr.21096","article-title":"Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations.","volume":"3","author":"Rudmik","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"issue":"1","key":"ooi180033r12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.otohns.2008.04.020","article-title":"Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation.","volume":"139","author":"Harvey","year":"2008","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"ooi180033r13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00005537-200402000-00004","article-title":"Comparison of topical medication delivery systems after sinus surgery.","volume":"114","author":"Miller","year":"2004","journal-title":"Laryngoscope"},{"key":"ooi180033r14","first-page":"S22","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis.","volume":"6","author":"Orlandi","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"issue":"9","key":"ooi180033r15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/alr.21172","article-title":"Distribution of topical agents to the paranasal sinuses: an evidence-based review with recommendations.","volume":"3","author":"Thomas","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"issue":"3","key":"ooi180033r16","first-page":"CD006394","article-title":"Nasal saline irrigations for the symptoms of chronic rhinosinusitis.","author":"Harvey","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"ooi180033r17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/0194599813510885","article-title":"Limited evidence: higher efficacy of nasal saline irrigation over nasal saline spray in chronic rhinosinusitis--an update and reanalysis of the evidence base.","volume":"150","author":"van den Berg","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"12","key":"ooi180033r18","first-page":"1049","article-title":"Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial.","volume":"51","author":"Rabago","year":"2002","journal-title":"J Fam Pract"},{"issue":"11","key":"ooi180033r19","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/archotol.133.11.1115","article-title":"Nasal saline for chronic sinonasal symptoms: a randomized controlled trial.","volume":"133","author":"Pynnonen","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"4","key":"ooi180033r20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1370\/afm.552","article-title":"Qualitative aspects of nasal irrigation use by patients with chronic sinus disease in a multimethod study.","volume":"4","author":"Rabago","year":"2006","journal-title":"Ann Fam Med"},{"issue":"5","key":"ooi180033r21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/alr.21047","article-title":"Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis.","volume":"2","author":"Snidvongs","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"issue":"3","key":"ooi180033r22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archoto.2008.555","article-title":"The effect of nasally administered budesonide respules on adrenal cortex function in patients with chronic rhinosinusitis.","volume":"135","author":"Sachanandani","year":"2009","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"6","key":"ooi180033r23","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jaci.2009.09.018","article-title":"Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis.","volume":"124","author":"Steinke","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"20","key":"ooi180033r24","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1001\/jama.291.20.2441","article-title":"Prognostic importance of comorbidity in a hospital-based cancer registry.","volume":"291","author":"Piccirillo","year":"2004","journal-title":"JAMA"},{"issue":"5","key":"ooi180033r25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test.","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clin Otolaryngol"},{"issue":"10","key":"ooi180033r26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/alr.21366","article-title":"Endoscopic sinus surgery compared to continued medical therapy for patients with refractory chronic rhinosinusitis.","volume":"4","author":"Smith","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"issue":"7","key":"ooi180033r27","first-page":"28","article-title":"The Clinical Global Impressions scale: applying a research tool in clinical practice.","volume":"4","author":"Busner","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"issue":"3 Pt 2","key":"ooi180033r28","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis.","volume":"117","author":"Lund","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"ooi180033r29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4065\/77.4.371","article-title":"Methods to explain the clinical significance of health status measures.","volume":"77","author":"Guyatt","year":"2002","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"ooi180033r30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jaci.2013.02.036","article-title":"Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.","volume":"131","author":"Akdis","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"ooi180033r31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/alr.21780","article-title":"Is there a future for biologics in the management of chronic rhinosinusitis?","volume":"6","author":"Lam","year":"2016","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2683622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T06:23:58Z","timestamp":1604384638000},"score":1,"resource":{"primary":{"URL":"http:\/\/archotol.jamanetwork.com\/article.aspx?doi=10.1001\/jamaoto.2018.0667"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2018,7,1]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2018.0667","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,1]]}}}