{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:15:32Z","timestamp":1759058132982},"reference-count":10,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1001\/jamaoto.2018.1101","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T18:43:29Z","timestamp":1533235409000},"page":"776","source":"Crossref","is-referenced-by-count":8,"title":["Dornase Alfa Ototoxic Effects in Animals and Efficacy in the Treatment of Clogged Tympanostomy Tubes in Children"],"prefix":"10.1001","volume":"144","author":[{"given":"Kenny H.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory C.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy E.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven-Olrik","family":"Streubel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman R.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda G.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Colorado School of Medicine, Aurora"},{"name":"Department of Pediatric Otolaryngology, Children\u2019s Hospital Colorado, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy T. K.","family":"Jung","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Medicine, Loma Linda, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"6","key":"ooi180044r1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1542\/peds.107.6.1251","article-title":"Otorrhea in young children after tympanostomy-tube placement for persistent middle-ear effusion: prevalence, incidence, and duration.","volume":"107","author":"Ah-Tye","year":"2001","journal-title":"Pediatrics"},{"issue":"2-3","key":"ooi180044r2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0165-5876(94)01105-7","article-title":"A prospective randomised trial of the use of sodium bicarbonate and hydrogen peroxide ear drops to clear a blocked tympanostomy tube.","volume":"31","author":"Spraggs","year":"1995","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"ooi180044r3","first-page":"65","article-title":"Dornase alfa for cystic fibrosis.","volume":"21","author":"Yang","year":"2017","journal-title":"Paediatr Respir Rev"},{"issue":"1","key":"ooi180044r4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1378\/chest.120.1.203","article-title":"Efficacy of recombinant human deoxyribonuclease I in the hospital management of respiratory syncytial virus bronchiolitis.","volume":"120","author":"Nasr","year":"2001","journal-title":"Chest"},{"issue":"4","key":"ooi180044r5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1136\/thorax.58.4.365","article-title":"Successful treatment of empyema thoracis with human recombinant deoxyribonuclease.","volume":"58","author":"Simpson","year":"2003","journal-title":"Thorax"},{"issue":"7","key":"ooi180044r6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1136\/adc.88.7.626","article-title":"Treatment of plastic bronchitis in acute chest syndrome of sickle cell disease with intratracheal rhDNase.","volume":"88","author":"Manna","year":"2003","journal-title":"Arch Dis Child"},{"issue":"6","key":"ooi180044r7","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1097\/00005537-200206000-00003","article-title":"Defining tympanostomy tube plugs.","volume":"112","author":"Westine","year":"2002","journal-title":"Laryngoscope"},{"issue":"2","key":"ooi180044r8","doi-asserted-by":"publisher","first-page":"e53837","DOI":"10.1371\/journal.pone.0053837","article-title":"Neutrophil extracellular traps and bacterial biofilms in middle ear effusion of children with recurrent acute otitis media: a potential treatment target.","volume":"8","author":"Thornton","year":"2013","journal-title":"PLoS One"},{"key":"ooi180044r9","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1288\/00005537-196205000-00005","article-title":"Enzyme treatment of ear infections: local use of pancreatic dornase.","volume":"72","author":"Loch","year":"1962","journal-title":"Laryngoscope"},{"key":"ooi180044r10","first-page":"171","article-title":"Effect of exogenous arachidonic acid metabolites applied on round window membrane on hearing and their levels in the perilymph.","volume":"493","author":"Jung","year":"1992","journal-title":"Acta Otolaryngol Suppl"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2688528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T16:20:45Z","timestamp":1537460445000},"score":1,"resource":{"primary":{"URL":"http:\/\/archotol.jamanetwork.com\/article.aspx?doi=10.1001\/jamaoto.2018.1101"}},"subtitle":["A Preclinical Study and a Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2018.1101","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}