{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:29:33Z","timestamp":1749036573916},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1001\/jamaoto.2018.1278","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T14:44:02Z","timestamp":1533221042000},"page":"781","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus"],"prefix":"10.1001","volume":"144","author":[{"given":"Helena Y.","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Karadaghy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branden","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay F.","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri"},{"name":"Editor, JAMA Otolaryngology\u2013Head & Neck Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Nagele","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"8","key":"ooi180047r1","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","article-title":"Prevalence and characteristics of tinnitus among US adults.","volume":"123","author":"Shargorodsky","year":"2010","journal-title":"Am J Med"},{"issue":"2","key":"ooi180047r2","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/13803395.2011.623120","article-title":"Effects of severe bothersome tinnitus on cognitive function measured with standardized tests.","volume":"34","author":"Pierce","year":"2012","journal-title":"J Clin Exp Neuropsychol"},{"issue":"9","key":"ooi180047r3","first-page":"CD005233","article-title":"Cognitive behavioural therapy for tinnitus.","author":"Martinez-Devesa","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"ooi180047r4","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599814545325","article-title":"Clinical practice guideline: tinnitus.","volume":"151","author":"Tunkel","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi180047r5","first-page":"CD010151","article-title":"Amplification with hearing aids for patients with tinnitus and co-existing hearing loss.","author":"Hoare","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"ooi180047r6","first-page":"CD006371","article-title":"Sound therapy (masking) in the management of tinnitus in adults.","volume":"11","author":"Hobson","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"ooi180047r7","first-page":"CD003853","article-title":"Antidepressants for patients with tinnitus.","author":"Baldo","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"ooi180047r8","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1001\/archotol.1993.01880200042006","article-title":"Use of alprazolam for relief of tinnitus. A double-blind study.","volume":"119","author":"Johnson","year":"1993","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"11","key":"ooi180047r9","first-page":"PI55","article-title":"The effects of alprazolam on tinnitus: a cross-over randomized clinical trial.","volume":"15","author":"Jalali","year":"2009","journal-title":"Med Sci Monit"},{"issue":"7","key":"ooi180047r10","first-page":"CD007960","article-title":"Anticonvulsants for tinnitus.","author":"Hoekstra","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"ooi180047r11","first-page":"CD009832","article-title":"Zinc supplementation for tinnitus.","volume":"11","author":"Person","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"ooi180047r12","first-page":"CD003852","article-title":"Ginkgo biloba for tinnitus.","author":"Hilton","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"ooi180047r13","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1001\/archotol.126.4.489","article-title":"Efficacy of acupuncture as a treatment for tinnitus: a systematic review.","volume":"126","author":"Park","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"10","key":"ooi180047r14","first-page":"CD007946","article-title":"Repetitive transcranial magnetic stimulation for tinnitus.","volume":"CD007946","author":"Meng","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"ooi180047r15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.biopsych.2014.11.016","article-title":"Nitrous oxide for treatment-resistant major depression: a proof-of-concept trial.","volume":"78","author":"Nagele","year":"2015","journal-title":"Biol Psychiatry"},{"issue":"2","key":"ooi180047r16","first-page":"76","article-title":"Endogenous dynorphins: possible role in peripheral tinnitus.","volume":"5","author":"Sahley","year":"1999","journal-title":"Int Tinnitus J"},{"issue":"1","key":"ooi180047r17","first-page":"37","article-title":"Characteristics of tinnitus and etiology of associated hearing loss: a study of 123 patients.","volume":"8","author":"Nicolas-Puel","year":"2002","journal-title":"Int Tinnitus J"},{"key":"ooi180047r18","doi-asserted-by":"publisher","first-page":"80904","DOI":"10.1155\/2007\/80904","article-title":"Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma.","volume":"2007","author":"Guitton","year":"2007","journal-title":"Neural Plast"},{"key":"ooi180047r19","first-page":"19","article-title":"Cochlear NMDA receptor blockade prevents salicylate-induced tinnitus.","volume":"3","author":"Puel","year":"2007","journal-title":"B-ENT"},{"key":"ooi180047r20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.neuroscience.2014.11.027","article-title":"From development to disease: diverse functions of NMDA-type glutamate receptors in the lower auditory pathway.","volume":"285","author":"Sanchez","year":"2015","journal-title":"Neuroscience"},{"key":"ooi180047r21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fnsys.2012.00012","article-title":"Tinnitus: pathology of synaptic plasticity at the cellular and system levels.","volume":"6","author":"Guitton","year":"2012","journal-title":"Front Syst Neurosci"},{"issue":"2","key":"ooi180047r23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support.","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"2","key":"ooi180047r24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/AUD.0b013e31822f67c0","article-title":"The Tinnitus Functional Index: development of a new clinical measure for chronic, intrusive tinnitus [published correction appears in Ear Hear. 2012;33(3):443].","volume":"33","author":"Meikle","year":"2012","journal-title":"Ear Hear"},{"issue":"1","key":"ooi180047r25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1001\/jamaoto.2014.2669","article-title":"A novel treatment for tinnitus and tinnitus-related cognitive difficulties using computer-based cognitive training and D-cycloserine.","volume":"141","author":"Krings","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"5","key":"ooi180047r26","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1177\/0194599815571556","article-title":"Effects of mindfulness based stress reduction therapy on subjective bother and neural connectivity in chronic tinnitus.","volume":"152","author":"Roland","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"ooi180047r27","doi-asserted-by":"publisher","first-page":"983","DOI":"10.2307\/2533558","article-title":"Small sample inference for fixed effects from restricted maximum likelihood.","volume":"53","author":"Kenward","year":"1997","journal-title":"Biometrics"},{"key":"ooi180047r28","doi-asserted-by":"publisher","first-page":"S106","DOI":"10.1080\/14992020802301670","article-title":"Understanding tinnitus distress: introducing the concepts of moderators and mediators.","volume":"47","author":"Andersson","year":"2008","journal-title":"Int J Audiol"},{"issue":"6","key":"ooi180047r29","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1177\/019459988409200618","article-title":"Placebo effect in tinnitus management.","volume":"92","author":"Duckert","year":"1984","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1-2","key":"ooi180047r30","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.heares.2005.02.013","article-title":"Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus.","volume":"206","author":"Kaltenbach","year":"2005","journal-title":"Hear Res"},{"key":"ooi180047r22","unstructured":"American Society of Anesthesiologists. Standards for basic anesthetic monitoring. https:\/\/www.asahq.org\/~\/media\/Sites\/ASAHQ\/Files\/Public\/Resources\/standards-guidelines\/standards-for-basic-anesthetic-monitoring.pdf. Published 2015. Accessed June 18, 2018."}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2688529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T12:20:38Z","timestamp":1537446038000},"score":1,"resource":{"primary":{"URL":"http:\/\/archotol.jamanetwork.com\/article.aspx?doi=10.1001\/jamaoto.2018.1278"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2018.1278","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}