{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:57:02Z","timestamp":1776211022652,"version":"3.50.1"},"reference-count":20,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1001\/jamaoto.2019.0269","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T11:35:44Z","timestamp":1554377744000},"page":"494","source":"Crossref","is-referenced-by-count":55,"title":["Comparison of Ibuprofen vs Acetaminophen and Severe Bleeding Risk After Pediatric Tonsillectomy"],"prefix":"10.1001","volume":"145","author":[{"given":"Gillian R.","family":"Diercks","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Comins","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Bennett","sequence":"additional","affiliation":[{"name":"Bennett Statistical Consulting Inc, Ballston Lake, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Q.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Naval Medical Center Portsmouth, Portsmouth, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brigger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Naval Medical Center San Diego, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Boseley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Madigan Army Medical Center, Tacoma, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Gaudreau","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Naval Medical Center San Diego, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Madigan Army Medical Center, Tacoma, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Setlur","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Keamy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Hartnick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts"},{"name":"Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"6","key":"ooi190009r1","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.otohns.2009.01.044","article-title":"Changes in incidence and indications of tonsillectomy and adenotonsillectomy, 1970-2005.","volume":"140","author":"Erickson","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ooi190009r2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/00034894921010S112","article-title":"Current indications for tonsillectomy and adenoidectomy.","volume":"155","author":"Bluestone","year":"1992","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"issue":"6","key":"ooi190009r3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1001\/archotol.1990.01870060043006","article-title":"Tonsillectomy in children under 3 years of age.","volume":"116","author":"Berkowitz","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"ooi190009r4","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.otohns.2008.12.005","article-title":"Post-tonsillectomy bleeding: how much is too much?","volume":"140","author":"Blakley","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"ooi190009r5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/S0194-5998(98)70107-X","article-title":"Ibuprofen for tonsillectomy pain in children: efficacy and complications.","volume":"119","author":"Harley","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi190009r6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0194-5998(97)70211-0","article-title":"A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.","volume":"117","author":"St Charles","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ooi190009r7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1001\/archotol.1964.00750040220021","article-title":"Aspirin vs acetaminophen after tonsillectomy.","volume":"80","author":"Reuter","year":"1964","journal-title":"Arch Otolaryngol"},{"issue":"3","key":"ooi190009r8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/jcph.1995.35.issue-3","article-title":"Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis.","volume":"35","author":"Schafer","year":"1995","journal-title":"J Clin Pharmacol"},{"issue":"2","key":"ooi190009r9","first-page":"CD003591","article-title":"Non-steroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy.","author":"Cardwell","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"ooi190009r10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/coa.2013.38.issue-2","article-title":"A 2013 updated systematic review & meta-analysis of 36 randomized controlled trials; no apparent effects of non steroidal anti-inflammatory agents on the risk of bleeding after tonsillectomy.","volume":"38","author":"Riggin","year":"2013","journal-title":"Clin Otolaryngol"},{"issue":"3","key":"ooi190009r11","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1177\/0194599816646363","article-title":"The use of ibuprofen in posttonsillectomy analgesia and its effect on posttonsillectomy hemorrhage rate.","volume":"155","author":"Pfaff","year":"2016","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"7","key":"ooi190009r12","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1001\/jamaoto.2016.3839","article-title":"Association between ibuprofen and the severity of surgically managed posttonsillectomy hemorrhage.","volume":"143","author":"Mudd","year":"2017","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"12","key":"ooi190009r13","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1001\/2012.jama.11575","article-title":"Perioperative dexamethasone administration and risk of bleeding following tonsillectomy in children: a randomized controlled trial.","volume":"308","author":"Gallagher","year":"2012","journal-title":"JAMA"},{"issue":"5","key":"ooi190009r14","doi-asserted-by":"publisher","first-page":"e1343","DOI":"10.1542\/peds.2011-2538","article-title":"More codeine fatalities after tonsillectomy in North American children.","volume":"129","author":"Kelly","year":"2012","journal-title":"Pediatrics"},{"issue":"2","key":"ooi190009r15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1542\/peds.2014-1906","article-title":"Morphine or ibuprofen for post-tonsillectomy analgesia: a randomized trial.","volume":"135","author":"Kelly","year":"2015","journal-title":"Pediatrics"},{"issue":"1","key":"ooi190009r16","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599810389949","article-title":"Clinical practice guideline: tonsillectomy in children.","volume":"144","author":"Baugh","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"ooi190009r17","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1001\/archotol.125.3.330","article-title":"Avoidance of primary post-tonsillectomy hemorrhage in a teaching program.","volume":"125","author":"Conley","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"6","key":"ooi190009r18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1046\/j.1365-2273.2003.00763.x","article-title":"Assessment of secondary haemorrhage rates following adult tonsillectomy: a telephone survey and literature review.","volume":"28","author":"Evans","year":"2003","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"2","key":"ooi190009r19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1600-0609.1984.tb02390.x","article-title":"Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans.","volume":"33","author":"Cronberg","year":"1984","journal-title":"Scand J Haematol"},{"issue":"5","key":"ooi190009r20","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/cpt.1978.24.issue-5","article-title":"Effect of ibuprofen on platelet function in normal subjects and hemophiliac patients.","volume":"24","author":"McIntyre","year":"1978","journal-title":"Clin Pharmacol Ther"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamaotolaryngology\/article-pdf\/145\/6\/494\/17650139\/jamaotolaryngology_diercks_2019_oi_190009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T11:04:15Z","timestamp":1561028655000},"score":1,"resource":{"primary":{"URL":"http:\/\/archotol.jamanetwork.com\/article.aspx?doi=10.1001\/jamaoto.2019.0269"}},"subtitle":["A Noninferiority Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2019.0269","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,1]]}}}