{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:45:25Z","timestamp":1793411125852,"version":"4.5.0"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2019,11,1]]},"DOI":"10.1001\/jamaoto.2019.2427","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T15:31:45Z","timestamp":1567697505000},"page":"1012","source":"Crossref","is-referenced-by-count":148,"title":["Prognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1001","volume":"145","author":[{"given":"Matthew E.","family":"Spector","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Bellile","sequence":"additional","affiliation":[{"name":"Center for Cancer Biostatistics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahin","family":"Amlani","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Zarins","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Chad","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rozek","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daffyd","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M. G.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Center for Cancer Biostatistics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the University of Michigan Head and Neck SPORE Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"7","key":"ooi190056r1","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/hed.v38.7","article-title":"Tumor-infiltrating lymphocytes  and survival in patients with head and neck squamous cell carcinoma.","volume":"38","author":"Nguyen","year":"2016","journal-title":"Head Neck"},{"issue":"1","key":"ooi190056r2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/ijc.29683","article-title":"CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG).","volume":"138","author":"Balermpas","year":"2016","journal-title":"Int J Cancer"},{"issue":"2","key":"ooi190056r3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1158\/1078-0432.CCR-05-1886","article-title":"Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers.","volume":"12","author":"Badoual","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"2","key":"ooi190056r4","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/bjc.2013.640","article-title":"Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer.","volume":"110","author":"Balermpas","year":"2014","journal-title":"Br J Cancer"},{"key":"ooi190056r5","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.oraloncology.2016.08.003","article-title":"Telltale tumor-infiltrating lymphocytes  (TIL) in oral, head & neck cancer.","volume":"61","author":"Lei","year":"2016","journal-title":"Oral Oncol"},{"issue":"2","key":"ooi190056r6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1177\/019459988609500203","article-title":"Lymphocyte subpopulations infiltrating squamous carcinomas of the head and neck: correlations with extent of tumor and prognosis.","volume":"95","author":"Wolf","year":"1986","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi190056r7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(ISSN)1097-0215","article-title":"Tissue microarrays (TMAs) for high-throughput molecular pathology research.","volume":"94","author":"Nocito","year":"2001","journal-title":"Int J Cancer"},{"issue":"1","key":"ooi190056r8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.oraloncology.2014.09.006","article-title":"Tumor-infiltrating lymphocytes  (TIL) and prognosis in oral cavity squamous carcinoma: a preliminary study.","volume":"51","author":"Wolf","year":"2015","journal-title":"Oral Oncol"},{"issue":"1","key":"ooi190056r9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/lary.v122.1","article-title":"Infiltrating lymphocytes and human papillomavirus-16--associated oropharyngeal cancer.","volume":"122","author":"Wansom","year":"2012","journal-title":"Laryngoscope"},{"issue":"12","key":"ooi190056r10","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1001\/jamaoto.2013.5460","article-title":"High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods.","volume":"139","author":"Walline","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"19","key":"ooi190056r11","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1200\/JCO.2007.12.7662","article-title":"EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer.","volume":"26","author":"Kumar","year":"2008","journal-title":"J Clin Oncol"},{"issue":"1","key":"ooi190056r12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/hed.23548","article-title":"Human papillomavirus-related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor.","volume":"37","author":"Vainshtein","year":"2015","journal-title":"Head Neck"},{"issue":"10","key":"ooi190056r13","doi-asserted-by":"publisher","first-page":"e167","DOI":"10.1016\/j.oraloncology.2009.05.640","article-title":"Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: prognostic impact may depend on type of treatment and stage of disease.","volume":"45","author":"Distel","year":"2009","journal-title":"Oral Oncol"},{"key":"ooi190056r14","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/1471-2407-9-292","article-title":"Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma.","volume":"9","author":"Pretscher","year":"2009","journal-title":"BMC Cancer"},{"issue":"2","key":"ooi190056r15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/bjc.2013.639","article-title":"Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.","volume":"110","author":"Ward","year":"2014","journal-title":"Br J Cancer"},{"key":"ooi190056r16","doi-asserted-by":"publisher","first-page":"36956","DOI":"10.1038\/srep36956","article-title":"PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients.","volume":"6","author":"Kim","year":"2016","journal-title":"Sci Rep"},{"issue":"7","key":"ooi190056r17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1200\/JCO.18.01010","article-title":"Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers.","volume":"37","author":"Loi","year":"2019","journal-title":"J Clin Oncol"},{"issue":"Pt 2","key":"ooi190056r18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.semcancer.2017.10.003","article-title":"Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.","volume":"52","author":"Dieci","year":"2018","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"ooi190056r19","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1356148","article-title":"The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis.","volume":"6","author":"de Ruiter","year":"2017","journal-title":"Oncoimmunology"},{"issue":"12","key":"ooi190056r20","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1001\/archoto.2010.211","article-title":"Correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer.","volume":"136","author":"Wansom","year":"2010","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"15","key":"ooi190056r21","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1200\/JCO.2010.30.5037","article-title":"Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer.","volume":"29","author":"Mahmoud","year":"2011","journal-title":"J Clin Oncol"},{"issue":"7","key":"ooi190056r22","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1158\/1078-0432.CCR-13-2830","article-title":"Prognostic and predictive values of the immunoscore in patients with rectal cancer.","volume":"20","author":"Anitei","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"1","key":"ooi190056r23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/hed.v36.1","article-title":"Circulating CD4-positive lymphocyte levels as predictor of response to induction chemotherapy in patients with advanced laryngeal cancer.","volume":"36","author":"Dewyer","year":"2014","journal-title":"Head Neck"},{"issue":"2","key":"ooi190056r24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00262-018-2256-3","article-title":"Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma.","volume":"68","author":"Mann","year":"2019","journal-title":"Cancer Immunol Immunother"},{"key":"ooi190056r25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.oraloncology.2018.04.008","article-title":"Nivolumab vs investigator\u2019s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression.","volume":"81","author":"Ferris","year":"2018","journal-title":"Oral Oncol"},{"issue":"14","key":"ooi190056r26","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1200\/JCO.2016.70.1524","article-title":"Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: results from a single-arm, phase II study.","volume":"35","author":"Bauml","year":"2017","journal-title":"J Clin Oncol"},{"issue":"3","key":"ooi190056r27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/CCO.0000000000000522","article-title":"Immunotherapy in recurrent and or metastatic squamous cell carcinoma of the head and neck.","volume":"31","author":"Saada-Bouzid","year":"2019","journal-title":"Curr Opin Oncol"},{"issue":"8","key":"ooi190056r28","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1002\/hed.v41.8","article-title":"A gene signature associated with prognosis and immune processes in head and neck squamous cell carcinoma.","volume":"41","author":"Bai","year":"2019","journal-title":"Head Neck"},{"issue":"9","key":"ooi190056r29","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1200\/JCO.2014.58.1967","article-title":"Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.","volume":"33","author":"Denkert","year":"2015","journal-title":"J Clin Oncol"},{"issue":"1","key":"ooi190056r30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/lary.v124.1","article-title":"Biomarkers in advanced larynx cancer.","volume":"124","author":"Bradford","year":"2014","journal-title":"Laryngoscope"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/articlepdf\/2748993\/jamaotolaryngology_spector_2019_oi_190056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T16:01:08Z","timestamp":1574352068000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2748993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2019.2427","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11,1]]}}}