{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:22:48Z","timestamp":1790738568625,"version":"4.1.0"},"reference-count":31,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2020,11,1]]},"DOI":"10.1001\/jamaoto.2020.3053","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T16:38:23Z","timestamp":1600360703000},"page":"1054","source":"Crossref","is-referenced-by-count":68,"title":["In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2"],"prefix":"10.1001","volume":"146","author":[{"given":"Samantha","family":"Frank","sequence":"first","affiliation":[{"name":"University of Connecticut School of Medicine, Farmington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Brown","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine, Farmington"},{"name":"ProHealth, Ear, Nose and Throat, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Capriotti","sequence":"additional","affiliation":[{"name":"Veloce BioPharma, Fort Lauderdale, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna B.","family":"Westover","sequence":"additional","affiliation":[{"name":"The Institute for Antiviral Research at Utah State University, Logan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse S.","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Ocean Ophthalmology, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belachew","family":"Tessema","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine, Farmington"},{"name":"ProHealth, Ear, Nose and Throat, Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"12","key":"ooi200049r1","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients.","volume":"382","author":"Zou","year":"2020","journal-title":"N Engl J Med"},{"issue":"5","key":"ooi200049r2","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat Med"},{"issue":"16","key":"ooi200049r3","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and surface stability of SARS-CoV-2 compared with SARS-CoV-1.","volume":"382","author":"van Doremalen","year":"2020","journal-title":"N Engl J Med"},{"issue":"6","key":"ooi200049r4","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1177\/0194599820919751","article-title":"COVID-19 pandemic: what every otolaryngologist\u2013head and neck surgeon needs to know for safe airway management.","volume":"162","author":"Balakrishnan","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"7","key":"ooi200049r5","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1002\/alr.v10.7","article-title":"Endonasal instrumentation and aerosolization risk in the era of COVID-19: simulation, literature review, and proposed mitigation strategies.","volume":"10","author":"Workman","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"ooi200049r6","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.cell.2020.05.042","article-title":"SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract.","volume":"182","author":"Hou","year":"2020","journal-title":"Cell"},{"issue":"7809","key":"ooi200049r7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019.","volume":"581","author":"W\u00f6lfel","year":"2020","journal-title":"Nature"},{"issue":"1","key":"ooi200049r8","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41467-020-14626-0","article-title":"Influenza A viruses are transmitted via the air from the nasal respiratory epithelium of ferrets.","volume":"11","author":"Richard","year":"2020","journal-title":"Nat Commun"},{"key":"ooi200049r9","doi-asserted-by":"crossref","DOI":"10.1111\/jopr.13207","article-title":"SARS-CoV-2 viral inactivation using low dose povidone-iodine oral rinse\u2014immediate application for the prosthodontic practice.","author":"Tessema","year":"2020","journal-title":"J Prosthodont"},{"key":"ooi200049r10","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104724","article-title":"Consideration of povidone-iodine as a public health intervention for COVID-19: utilization as \u201cpersonal protective equipment\u201d for frontline providers exposed in high-risk head and neck and skull base oncology care.","volume":"105","author":"Mady","year":"2020","journal-title":"Oral Oncol"},{"issue":"6","key":"ooi200049r11","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1002\/hed.v42.6","article-title":"Topical preparations to reduce SARS-CoV-2 aerosolization in head and neck mucosal surgery.","volume":"42","author":"Parhar","year":"2020","journal-title":"Head Neck"},{"issue":"9","key":"ooi200049r12","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41415-020-1589-4","article-title":"Povidone iodine.","volume":"228","author":"Challacombe","year":"2020","journal-title":"Br Dent J"},{"issue":"2","key":"ooi200049r13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s40121-018-0200-7","article-title":"In vitro bactericidal and virucidal efficacy of povidone-iodine gargle\/mouthwash against respiratory and oral tract pathogens.","volume":"7","author":"Eggers","year":"2018","journal-title":"Infect Dis Ther"},{"key":"ooi200049r14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000089211","article-title":"Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.","volume":"212","author":"Kariwa","year":"2006","journal-title":"Dermatology"},{"key":"ooi200049r15","article-title":"Rapid in-vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse.","author":"Bidra","year":"2020","journal-title":"J Prosthodont"},{"issue":"3","key":"ooi200049r16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty percent endpoints.","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Epidemiol"},{"key":"ooi200049r17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000057738","article-title":"Antimicrobial effectiveness of povidone-iodine and consequences for new application areas.","volume":"204","author":"Reimer","year":"2002","journal-title":"Dermatology"},{"key":"ooi200049r18","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1017\/S0022215114002746","article-title":"Betadine has a ciliotoxic effect on ciliated human respiratory cells.","volume":"129","author":"Kim","year":"2015","journal-title":"J Laryngol Otol"},{"key":"ooi200049r19","doi-asserted-by":"crossref","DOI":"10.1177\/0145561320932318","article-title":"Povidone-iodine use in sinonasal and oral cavities: a review of safety in the COVID-19 era.","author":"Frank","year":"2020","journal-title":"Ear Nose Throat J"},{"issue":"12","key":"ooi200049r20","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1007\/s00405-019-05628-w","article-title":"The efficacy of diluted topical povidone-iodine rinses in the management of recalcitrant chronic rhinosinusitis: a prospective cohort study.","volume":"276","author":"Panchmatia","year":"2019","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"ooi200049r21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.5152\/ejra.","article-title":"Topical povidone-iodine as an adjunctive treatment for recalcitrant chronic rhinosinusitis.","volume":"2","author":"Mullings","year":"2019","journal-title":"Eur J Rhinol Allergy"},{"issue":"3","key":"ooi200049r22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1053\/jhin.2000.0733","article-title":"The in-vitro activity of povidone-iodinecream against Staphylococcus aureus and its bioavailability in nasal secretions.","volume":"45","author":"Hill","year":"2000","journal-title":"J Hosp Infect"},{"issue":"5","key":"ooi200049r23","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1039\/C4TB01516A","article-title":"Bactericidal magnetic nanoparticles with iodine loaded on surface grafted poly(N-vinylpyrrolidone).","volume":"3","author":"Au-Duong","year":"2015","journal-title":"J Mater Chem B"},{"issue":"4","key":"ooi200049r24","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s40121-019-00260-x","article-title":"Infectious disease management and control with povidone iodine.","volume":"8","author":"Eggers","year":"2019","journal-title":"Infect Dis Ther"},{"issue":"2","key":"ooi200049r25","first-page":"31","article-title":"The effect of 1% povidone iodine as a pre-procedural mouthrinse in 20 patients with varying degrees of oral hygiene.","volume":"48","author":"Domingo","year":"1996","journal-title":"J Philipp Dent Assoc"},{"key":"ooi200049r26","first-page":"53","article-title":"The relationship between autoimmune thyroid disease and iodine intake: a review.","volume":"43","author":"Foley","year":"1992","journal-title":"Endokrynol Pol"},{"issue":"3","key":"ooi200049r27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1538\/expanim.46.197","article-title":"125I uptake competing with iodine absorption by the thyroid gland following povidone-iodine skin application.","volume":"46","author":"Furudate","year":"1997","journal-title":"Exp Anim"},{"issue":"6","key":"ooi200049r28","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/jpc.2013.49.issue-6","article-title":"Recurrent anaphylaxis caused by topical povidone-iodine (betadine).","volume":"49","author":"Gray","year":"2013","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"ooi200049r29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/107175499266823","article-title":"Toxicological implications of nasal formulations.","volume":"6","author":"Quadir","year":"1999","journal-title":"Drug Deliv"},{"issue":"6","key":"ooi200049r30","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2500\/ajra.2014.28.4092","article-title":"The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium.","volume":"28","author":"Workman","year":"2014","journal-title":"Am J Rhinol Allergy"},{"key":"ooi200049r31","unstructured":"Povidone. United States Pharmacopeia and National Formulary. United States Pharmacopeia. May 1, 2019. Accessed August 18, 2020. https:\/\/www.usp.org\/sites\/default\/files\/usp\/document\/harmonization\/excipients\/m68070.pdf"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/articlepdf\/2770785\/jamaotolaryngology_frank_2020_oi_200049_1605715049.50571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T18:29:52Z","timestamp":1605810592000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2770785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2020.3053","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}