{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:04:52Z","timestamp":1790611492906,"version":"4.1.0"},"reference-count":34,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2022,6,1]]},"DOI":"10.1001\/jamaoto.2022.0684","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T19:30:51Z","timestamp":1651087851000},"page":"547","source":"Crossref","is-referenced-by-count":10,"title":["Perioperative Topical Antisepsis and Surgical Site Infection in Patients Undergoing Upper Aerodigestive Tract Reconstruction"],"prefix":"10.1001","volume":"148","author":[{"given":"Ahmed Sam","family":"Beydoun","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Koss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyson","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology, Methodist Estabrook Cancer Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew James","family":"Holcomb","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology, Methodist Estabrook Cancer Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Pichardo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, Geisinger Medical Center, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Purdy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, Geisinger Medical Center, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron L.","family":"Zebolsky","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase M.","family":"Heaton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin P.","family":"McMullen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck and Endocrine Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Yesensky","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerav","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Penn State College of Medicine, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kohan","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of Vermont Medical Center, Burlington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirabelle","family":"Sajisevi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery, University of Vermont Medical Center, Burlington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Oregon Health & Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Petrisor","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Oregon Health & Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Wax","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Oregon Health & Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Kejner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skylar","family":"Trott","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Richmon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan M.","family":"Graboyes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Medical University of South Carolina, Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Burton","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Tennessee Health Science Center, Memphis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Pipkorn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bruening","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth V.","family":"Puram","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Zenga","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"ooi220015r1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.v71.1","article-title":"Cancer statistics, 2021.","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"ooi220015r2","doi-asserted-by":"publisher","first-page":"873","DOI":"10.6004\/jnccn.2020.0031","article-title":"Head and neck cancers, version 2.2020, NCCN clinical practice guidelines in oncology.","volume":"18","author":"Pfister","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"issue":"1","key":"ooi220015r3","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/795483","article-title":"Reconstructive surgery for head and neck cancer patients.","volume":"2014","author":"Hanasono","year":"2014","journal-title":"Adv Med"},{"issue":"8","key":"ooi220015r4","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.ijom.2017.03.023","article-title":"Risk factors for free flap failure: a retrospective analysis of 881 free flaps for head and neck defect reconstruction.","volume":"46","author":"Zhou","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"ooi220015r5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1177\/0003489416672871","article-title":"Surgical site infections in major head and neck surgeries involving pedicled flap reconstruction.","volume":"126","author":"Goyal","year":"2017","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"ooi220015r6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40463-017-0206-2","article-title":"Surgical site infections following oral cavity cancer resection and reconstruction is a risk factor for plate exposure.","volume":"46","author":"Yao","year":"2017","journal-title":"J Otolaryngol Head Neck Surg"},{"issue":"11","key":"ooi220015r7","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1001\/archotol.1992.01880110027007","article-title":"Ampicillin-sulbactam vs clindamycin in head and neck oncologic surgery. The need for gram-negative coverage.","volume":"118","author":"Weber","year":"1992","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"2","key":"ooi220015r8","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/lary.v128.2","article-title":"Risk factors for thirty-day readmission following flap reconstruction of oncologic defects of the head and neck.","volume":"128","author":"Osborn","year":"2018","journal-title":"Laryngoscope"},{"issue":"4","key":"ooi220015r9","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1177\/0194599817712215","article-title":"Antibiotic prophylaxis in clean-contaminated head and neck surgery: a systematic review and meta-analysis.","volume":"157","author":"Vila","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"ooi220015r10","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1002\/hed.v38.10","article-title":"Surgical prophylaxis with gram-negative activity for reduction of surgical site infections after microvascular reconstruction for head and neck cancer.","volume":"38","author":"Wagner","year":"2016","journal-title":"Head Neck"},{"issue":"S1","key":"ooi220015r11","doi-asserted-by":"publisher","first-page":"E392","DOI":"10.1002\/hed.24005","article-title":"Head and neck free flap surgical site infections in the era of the Surgical Care Improvement Project.","volume":"38","author":"Yarlagadda","year":"2016","journal-title":"Head Neck"},{"issue":"12","key":"ooi220015r12","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1288\/00005537-197312000-00009","article-title":"Prophylactic antibiotics in oral, pharyngeal and laryngeal surgery for cancer: (a double-blind study).","volume":"83","author":"Dor","year":"1973","journal-title":"Laryngoscope"},{"issue":"12","key":"ooi220015r13","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1177\/014107688407701204","article-title":"Chemoprophylaxis in major head and neck surgery.","volume":"77","author":"Raine","year":"1984","journal-title":"J R Soc Med"},{"issue":"1","key":"ooi220015r14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/lary.v94.1","article-title":"Antimicrobial prophylaxis for contaminated head and neck surgery.","volume":"94","author":"Johnson","year":"1984","journal-title":"Laryngoscope"},{"issue":"1","key":"ooi220015r15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1089\/sur.2013.9999","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery.","volume":"14","author":"Bratzler","year":"2013","journal-title":"Surg Infect (Larchmt)"},{"issue":"6 Pt 1","key":"ooi220015r16","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1288\/00005537-199406000-00011","article-title":"The efficacy of topical antibiotic prophylaxis for contaminated head and neck surgery.","volume":"104","author":"Grandis","year":"1994","journal-title":"Laryngoscope"},{"issue":"2","key":"ooi220015r17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/00005537-200102000-00026","article-title":"The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction.","volume":"111","author":"Simons","year":"2001","journal-title":"Laryngoscope"},{"issue":"15","key":"ooi220015r18","doi-asserted-by":"publisher","first-page":"6080","DOI":"10.1200\/JCO.2018.36.15_suppl.6080","article-title":"Prevention of surgical site infection after oral cancer surgery by topical tetracycline: results of a multicenter randomized control trial.","volume":"36","author":"Funahara","year":"2018","journal-title":"J Clin Oncol"},{"issue":"2","key":"ooi220015r19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0196-6553(99)70088-X","article-title":"Guideline for prevention of surgical site infection, 1999.","volume":"27","author":"Mangram","year":"1999","journal-title":"Am J Infect Control"},{"issue":"1","key":"ooi220015r20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1288\/00005537-198801000-00007","article-title":"The use of topical oral antibiotics in head and neck prophylaxis: is it justified?","volume":"98","author":"Kirchner","year":"1988","journal-title":"Laryngoscope"},{"issue":"6","key":"ooi220015r21","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1177\/019459989110500611","article-title":"The effects of topical oral clindamycin antibiotic rinses on the bacterial content of saliva on healthy human subjects.","volume":"105","author":"Elledge","year":"1991","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"ooi220015r22","first-page":"625","article-title":"Effects of topical oral antiseptic rinses on bacterial counts of saliva in healthy human subjects.","volume":"118","author":"Balbuena","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi220015r23","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12903-020-1043-7","article-title":"Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study.","volume":"20","author":"Tsuda","year":"2020","journal-title":"BMC Oral Health"},{"key":"ooi220015r24","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1097\/SAP.0000000000000046","article-title":"Surgical site infections among high-risk patients in clean-contaminated head and neck reconstructive surgery: concordance with preoperative oral flora.","volume":"71","author":"Yang","year":"2013","journal-title":"Ann Plast Surg"},{"issue":"5","key":"ooi220015r25","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/lary.v125.5","article-title":"The time course and microbiology of surgical site infections after head and neck free flap surgery.","volume":"125","author":"Durand","year":"2015","journal-title":"Laryngoscope"},{"issue":"4","key":"ooi220015r26","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1007\/s12325-020-01269-2","article-title":"Perioperative antibiotics in clean-contaminated head and neck surgery: a systematic review and meta-analysis.","volume":"37","author":"Vander Poorten","year":"2020","journal-title":"Adv Ther"},{"issue":"2","key":"ooi220015r27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s15010-017-1110-4","article-title":"Influence of a strictly perioperative antibiotic prophylaxis vs a prolonged postoperative prophylaxis on surgical site infections in maxillofacial surgery.","volume":"46","author":"Bartella","year":"2018","journal-title":"Infection"},{"key":"ooi220015r28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591088","article-title":"The oral microbiome and cancer.","volume":"11","author":"Irfan","year":"2020","journal-title":"Front Immunol"},{"key":"ooi220015r29","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3389\/fmicb.2018.00862","article-title":"Oral microbiota community dynamics associated with oral squamous cell carcinoma staging.","volume":"9","author":"Yang","year":"2018","journal-title":"Front Microbiol"},{"issue":"5","key":"ooi220015r30","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1245\/s10434-014-3498-8","article-title":"Statistical analysis of surgical site infection after head and neck reconstructive surgery.","volume":"21","author":"Kamizono","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"ooi220015r31","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1001\/jamaoto.2015.0513","article-title":"Antibiotic prophylaxis in patients undergoing head and neck free flap reconstruction.","volume":"141","author":"Mitchell","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"11","key":"ooi220015r32","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1002\/hed.v43.11","article-title":"Risk factors for surgical site infection in free-flap reconstructive surgery for head and neck cancer: retrospective Australian cohort study.","volume":"43","author":"Gearing","year":"2021","journal-title":"Head Neck"},{"issue":"1","key":"ooi220015r33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/wrr.2009.17.issue-1","article-title":"Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized wound care center.","volume":"17","author":"Wicke","year":"2009","journal-title":"Wound Repair Regen"},{"issue":"3","key":"ooi220015r34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/ddg.2017.15.issue-3","article-title":"Pathogenesis of wound healing disorders in the elderly.","volume":"15","author":"Makrantonaki","year":"2017","journal-title":"J Dtsch Dermatol Ges"}],"container-title":["JAMA Otolaryngology\u2013Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/articlepdf\/2791783\/jamaotolaryngology_beydoun_2022_oi_220015_1653508662.74278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T15:01:21Z","timestamp":1654786881000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2791783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2022.0684","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}