{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:09:36Z","timestamp":1778818176665,"version":"3.51.4"},"reference-count":36,"publisher":"American Medical Association (AMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"DOI":"10.1001\/jamaoto.2022.1293","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T15:01:29Z","timestamp":1658415689000},"source":"Crossref","is-referenced-by-count":3,"title":["Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults"],"prefix":"10.1001","author":[{"given":"Kirsten F. A. A.","family":"Dabekaussen","sequence":"first","affiliation":[{"name":"Center for Surgery and Public Health, Department of Surgery, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Andriotti","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Department of Surgery, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Ye","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Department of Surgery, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis L.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Department of Surgery, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Y.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Shin","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Department of Surgery, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"issue":"7","key":"ooi220029r1","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1001\/jama.2010.1124","article-title":"Change in prevalence of hearing loss in US adolescents.","volume":"304","author":"Shargorodsky","year":"2010","journal-title":"JAMA"},{"issue":"4","key":"ooi220029r2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.otohns.2008.12.022","article-title":"The epidemiology of hearing impairment in the United States: newborns, children, and adolescents.","volume":"140","author":"Mehra","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ooi220029r3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ijporl.2016.07.003","article-title":"Pediatric sudden sensorineural hearing loss: Etiology, diagnosis and treatment in 20 children.","volume":"88","author":"Dedhia","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"ooi220029r4","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1542\/peds.2008-2869","article-title":"Medication use among children &lt;12 years of age in the United States: results from the Slone Survey.","volume":"124","author":"Vernacchio","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"ooi220029r5","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1542\/peds.2004-0311","article-title":"Increased use of second-generation macrolide antibiotics for children in nine health plans in the United States.","volume":"114","author":"Stille","year":"2004","journal-title":"Pediatrics"},{"issue":"3","key":"ooi220029r6","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1542\/peds.2013-2903","article-title":"Recent trends in outpatient antibiotic use in children.","volume":"133","author":"Vaz","year":"2014","journal-title":"Pediatrics"},{"issue":"2","key":"ooi220029r7","first-page":"127","article-title":"Clarithromycin induced reversible sensorineural hearing loss.","volume":"7","author":"Hajiioannou","year":"2011","journal-title":"B-ENT"},{"issue":"8891","key":"ooi220029r8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0140-6736(94)91030-8","article-title":"Ototoxicity with azithromycin.","volume":"343","author":"Wallace","year":"1994","journal-title":"Lancet"},{"issue":"7-8","key":"ooi220029r9","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1177\/106002809302700724","article-title":"Erythromycin-induced hypoacusis: 11 new cases and literature review.","volume":"27","author":"Sacrist\u00e1n","year":"1993","journal-title":"Ann Pharmacother"},{"issue":"6","key":"ooi220029r10","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1177\/019459988409200615","article-title":"Erythromycin ototoxicity: analysis and conclusions based on 22 case reports.","volume":"92","author":"Haydon","year":"1984","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1 Pt 1","key":"ooi220029r11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/000348947708600103","article-title":"Reversible sensorineural hearing loss with intravenous erythromycin lactobionate.","volume":"86","author":"Karmody","year":"1977","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"7","key":"ooi220029r12","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/archinte.1993.00410070063009","article-title":"Clinically significant hearing loss in renal allograft recipients treated with intravenous erythromycin.","volume":"153","author":"Vasquez","year":"1993","journal-title":"Arch Intern Med"},{"issue":"1","key":"ooi220029r13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0002-9343(92)90016-5","article-title":"Erythromycin ototoxicity: prospective assessment with serum concentrations and audiograms in a study of patients with pneumonia.","volume":"92","author":"Swanson","year":"1992","journal-title":"Am J Med"},{"issue":"10","key":"ooi220029r14","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1177\/0003489418788112","article-title":"Does clarithromycin cause hearing loss? a 12-year review of clarithromycin therapy for nontuberculous mycobacterial lymphadenitis in children.","volume":"127","author":"Heffernan","year":"2018","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"ooi220029r15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1177\/0194599814526561","article-title":"Societal-level risk factors associated with pediatric hearing loss: a systematic review.","volume":"151","author":"Vasconcellos","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"ooi220029r16","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx220","article-title":"Outpatient macrolide antibiotic prescribing in the United States, 2008-2011.","volume":"4","author":"Sanchez","year":"2017","journal-title":"Open Forum Infect Dis"},{"issue":"9","key":"ooi220029r17","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1093\/cid\/civ076","article-title":"US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011.","volume":"60","author":"Hicks","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"20","key":"ooi220029r18","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1001\/jama.2011.679","article-title":"Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial.","volume":"305","author":"Rauch","year":"2011","journal-title":"JAMA"},{"issue":"1","key":"ooi220029r19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/lary.v128.1","article-title":"Macrolide-associated sensorineural hearing loss: A systematic review.","volume":"128","author":"Ikeda","year":"2018","journal-title":"Laryngoscope"},{"issue":"1","key":"ooi220029r20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/lary.26190","article-title":"Risk of sensorineural hearing loss with macrolide antibiotics: A nested case-control study.","volume":"127","author":"Etminan","year":"2017","journal-title":"Laryngoscope"},{"issue":"5","key":"ooi220029r21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1179\/1973947815Y.0000000054","article-title":"Fluoroquinolones in children: update of the literature.","volume":"27","author":"Bacci","year":"2015","journal-title":"J Chemother"},{"issue":"3","key":"ooi220029r23","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1542\/peds.47.3.567","article-title":"Tetracyclines and permanent teeth: the relation between dose and tooth color.","volume":"47","author":"Grossman","year":"1971","journal-title":"Pediatrics"},{"issue":"2","key":"ooi220029r24","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/00129492-200303000-00003","article-title":"Sensorineural hearing loss in chronic otitis media.","volume":"24","author":"Papp","year":"2003","journal-title":"Otol Neurotol"},{"issue":"1","key":"ooi220029r25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ijporl.2014.10.025","article-title":"Risk factors for sensorineural hearing loss in pediatric chronic otitis media.","volume":"79","author":"Yehudai","year":"2015","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"ooi220029r26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00405-008-0739-0","article-title":"Sensorineural hearing loss in patients with chronic otitis media.","volume":"266","author":"da Costa","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"5","key":"ooi220029r27","doi-asserted-by":"publisher","first-page":"346","DOI":"10.2165\/00002018-199309050-00004","article-title":"Adverse effects of macrolide antibacterials.","volume":"9","author":"Periti","year":"1993","journal-title":"Drug Saf"},{"issue":"1","key":"ooi220029r28","doi-asserted-by":"publisher","first-page":"e96","DOI":"10.1542\/peds.114.1.e96","article-title":"Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis.","volume":"114","author":"Langley","year":"2004","journal-title":"Pediatrics"},{"key":"ooi220029r29","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/S0924-8579(01)00397-1","article-title":"Comparative safety of the different macrolides.","volume":"18","author":"Rubinstein","year":"2001","journal-title":"Int J Antimicrob Agents"},{"issue":"4","key":"ooi220029r30","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1542\/peds.2009-1997","article-title":"Hearing assessment in infants and children: recommendations beyond neonatal screening.","volume":"124","author":"Harlor","year":"2009","journal-title":"Pediatrics"},{"issue":"2","key":"ooi220029r32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/bjc.1969.41","article-title":"The two \u201chit\u201d and multiple \u201chit\u201d theories of carcinogenesis.","volume":"23","author":"Ashley","year":"1969","journal-title":"Br J Cancer"},{"issue":"28","key":"ooi220029r33","first-page":"57","article-title":"Epidemiology in practice: case-control studies.","volume":"11","author":"Lewallen","year":"1998","journal-title":"Community Eye Health"},{"issue":"3","key":"ooi220029r34","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1067\/mcp.2001.117703","article-title":"Ethnic differences and relationships in the oral pharmacokinetics of nifedipine and erythromycin.","volume":"70","author":"Yu","year":"2001","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"ooi220029r35","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s40262-014-0209-3","article-title":"Interethnic differences in pharmacokinetics of antibacterials.","volume":"54","author":"Tsai","year":"2015","journal-title":"Clin Pharmacokinet"},{"issue":"7","key":"ooi220029r36","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1001\/jamasurg.2018.0480","article-title":"Practical guide to surgical data sets: military health system Tricare encounter data.","volume":"153","author":"Schoenfeld","year":"2018","journal-title":"JAMA Surg"},{"key":"ooi220029r22","first-page":"873","volume-title":"Red Book: 2015 Report of the Committee of Infectious Diseases","author":"American Academy of Pediatrics","year":"2015","edition":"30th ed"},{"key":"ooi220029r31","author":"Hagen","year":"2017"}],"container-title":["JAMA Otolaryngology\u2013Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/articlepdf\/2794472\/jamaotolaryngology_dabekaussen_2022_oi_220029_1658248889.52659.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T15:01:36Z","timestamp":1658415696000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2794472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":36,"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2022.1293","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,21]]}}}